CA3191390A1 - Lymphocytes b modifies et methodes d'utilisation associees - Google Patents
Lymphocytes b modifies et methodes d'utilisation associeesInfo
- Publication number
- CA3191390A1 CA3191390A1 CA3191390A CA3191390A CA3191390A1 CA 3191390 A1 CA3191390 A1 CA 3191390A1 CA 3191390 A CA3191390 A CA 3191390A CA 3191390 A CA3191390 A CA 3191390A CA 3191390 A1 CA3191390 A1 CA 3191390A1
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- Prior art keywords
- cell
- cells
- isolated modified
- patient
- modified
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Abstract
La présente invention concerne des lymphocytes B génétiquement modifiés et leurs utilisations, par exemple, pour le traitement de diverses affections et maladies, notamment du cancer, de maladies cardiaques, de maladies inflammatoires, de maladies liées à l'atrophie musculaire, de maladies neurologiques et analogues. Dans certains modes de réalisation, l'invention concerne un lymphocyte B modifié isolé ("cellule CAR-B") pouvant exprimer un récepteur chimérique ("récepteur CAR-B"), ledit récepteur chimérique comprenant (a) un domaine extracellulaire; (b) un domaine transmembranaire; et (c) un domaine cytoplasmique qui comprend au moins un domaine de signalisation. Dans divers modes de réalisation, l'invention comprend un lymphocyte B modifié isolé, ledit lymphocyte B pouvant exprimer et sécréter une charge utile; ladite charge utile n'étant pas naturellement exprimée dans un lymphocyte B ou étant exprimée à des niveaux supérieurs à celui qui est naturellement exprimé dans un lymphocyte B. Dans divers modes de réalisation, la charge utile est un anticorps ou un fragment de ce dernier.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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US202063073799P | 2020-09-02 | 2020-09-02 | |
US63/073,799 | 2020-09-02 | ||
PCT/US2021/048944 WO2022051556A1 (fr) | 2020-09-02 | 2021-09-02 | Lymphocytes b modifiés et méthodes d'utilisation associées |
Publications (1)
Publication Number | Publication Date |
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CA3191390A1 true CA3191390A1 (fr) | 2022-03-10 |
Family
ID=80491448
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA3191390A Pending CA3191390A1 (fr) | 2020-09-02 | 2021-09-02 | Lymphocytes b modifies et methodes d'utilisation associees |
Country Status (10)
Country | Link |
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EP (1) | EP4203978A1 (fr) |
JP (1) | JP2023539382A (fr) |
KR (1) | KR20230091865A (fr) |
CN (1) | CN116829160A (fr) |
AU (1) | AU2021337680A1 (fr) |
CA (1) | CA3191390A1 (fr) |
CL (1) | CL2023000602A1 (fr) |
IL (1) | IL301078A (fr) |
MX (1) | MX2023002603A (fr) |
WO (1) | WO2022051556A1 (fr) |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002092792A2 (fr) * | 2001-05-16 | 2002-11-21 | Genethor Gmbh | Procede de reduction de reactions immunitaires specifiques, liee aux antigenes, consistant a agir sur la co-stimulation |
WO2006063301A1 (fr) * | 2004-12-10 | 2006-06-15 | Maxcyte, Inc. | Cellules tumorales genetiquement modifiees servant de vaccins contre le cancer |
US20060263340A1 (en) * | 2005-04-29 | 2006-11-23 | Andrian Ulrich H V | Treating gastrointestinal diseases with modulators of retinoic acid |
US20180002664A1 (en) * | 2014-12-19 | 2018-01-04 | Immusoft Corporation | B cells for in vivo delivery of therapeutic agents |
EP3458157A4 (fr) * | 2016-05-19 | 2020-05-27 | Momenta Pharmaceuticals, Inc. | Procédés permettant de traiter des troubles associés à une fibrose et à une sclérodermie généralisée |
-
2021
- 2021-09-02 JP JP2023514455A patent/JP2023539382A/ja active Pending
- 2021-09-02 WO PCT/US2021/048944 patent/WO2022051556A1/fr active Application Filing
- 2021-09-02 CN CN202180073406.0A patent/CN116829160A/zh active Pending
- 2021-09-02 IL IL301078A patent/IL301078A/en unknown
- 2021-09-02 AU AU2021337680A patent/AU2021337680A1/en active Pending
- 2021-09-02 CA CA3191390A patent/CA3191390A1/fr active Pending
- 2021-09-02 KR KR1020237010666A patent/KR20230091865A/ko unknown
- 2021-09-02 MX MX2023002603A patent/MX2023002603A/es unknown
- 2021-09-02 EP EP21865143.8A patent/EP4203978A1/fr active Pending
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2023
- 2023-03-02 CL CL2023000602A patent/CL2023000602A1/es unknown
Also Published As
Publication number | Publication date |
---|---|
CL2023000602A1 (es) | 2023-08-04 |
KR20230091865A (ko) | 2023-06-23 |
JP2023539382A (ja) | 2023-09-13 |
AU2021337680A1 (en) | 2023-05-04 |
IL301078A (en) | 2023-05-01 |
MX2023002603A (es) | 2023-07-06 |
WO2022051556A1 (fr) | 2022-03-10 |
EP4203978A1 (fr) | 2023-07-05 |
CN116829160A (zh) | 2023-09-29 |
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