CA3187332A1 - Compositions and methods for treatment of fungal infections - Google Patents
Compositions and methods for treatment of fungal infectionsInfo
- Publication number
- CA3187332A1 CA3187332A1 CA3187332A CA3187332A CA3187332A1 CA 3187332 A1 CA3187332 A1 CA 3187332A1 CA 3187332 A CA3187332 A CA 3187332A CA 3187332 A CA3187332 A CA 3187332A CA 3187332 A1 CA3187332 A1 CA 3187332A1
- Authority
- CA
- Canada
- Prior art keywords
- cyclic peptide
- arginine
- amino acid
- cyclic
- defensin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 208000031888 Mycoses Diseases 0.000 title claims abstract description 28
- 238000000034 method Methods 0.000 title claims description 28
- 238000011282 treatment Methods 0.000 title claims description 23
- 206010017533 Fungal infection Diseases 0.000 title description 15
- 239000000203 mixture Substances 0.000 title description 8
- 230000000694 effects Effects 0.000 claims abstract description 33
- 206010040070 Septic Shock Diseases 0.000 claims abstract description 13
- 230000036303 septic shock Effects 0.000 claims abstract description 13
- 210000000987 immune system Anatomy 0.000 claims abstract description 11
- 230000028709 inflammatory response Effects 0.000 claims abstract description 9
- 239000012636 effector Substances 0.000 claims abstract description 8
- 108010069514 Cyclic Peptides Proteins 0.000 claims description 170
- 102000001189 Cyclic Peptides Human genes 0.000 claims description 168
- 150000001413 amino acids Chemical class 0.000 claims description 46
- 235000001014 amino acid Nutrition 0.000 claims description 43
- 235000009697 arginine Nutrition 0.000 claims description 40
- 239000004475 Arginine Substances 0.000 claims description 32
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims description 32
- 230000000843 anti-fungal effect Effects 0.000 claims description 31
- 230000002209 hydrophobic effect Effects 0.000 claims description 28
- 206010042938 Systemic candida Diseases 0.000 claims description 27
- 201000003984 candidiasis Diseases 0.000 claims description 27
- 230000004083 survival effect Effects 0.000 claims description 22
- 235000018417 cysteine Nutrition 0.000 claims description 20
- 208000037026 Invasive Fungal Infections Diseases 0.000 claims description 19
- 150000001945 cysteines Chemical class 0.000 claims description 19
- 208000019164 disseminated candidiasis Diseases 0.000 claims description 19
- 239000003814 drug Substances 0.000 claims description 17
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims description 12
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims description 12
- 230000006406 biphasic response Effects 0.000 claims description 12
- 239000004474 valine Substances 0.000 claims description 12
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims description 11
- 244000052769 pathogen Species 0.000 claims description 11
- 206010040047 Sepsis Diseases 0.000 claims description 10
- 125000000637 arginyl group Chemical group N[C@@H](CCCNC(N)=N)C(=O)* 0.000 claims description 10
- 201000010099 disease Diseases 0.000 claims description 10
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 10
- 238000010172 mouse model Methods 0.000 claims description 10
- 239000011159 matrix material Substances 0.000 claims description 9
- 210000002966 serum Anatomy 0.000 claims description 9
- 150000001484 arginines Chemical group 0.000 claims description 8
- 108090000695 Cytokines Proteins 0.000 claims description 7
- 102000004127 Cytokines Human genes 0.000 claims description 7
- 239000004471 Glycine Substances 0.000 claims description 6
- 210000004369 blood Anatomy 0.000 claims description 6
- 239000008280 blood Substances 0.000 claims description 6
- 230000000770 proinflammatory effect Effects 0.000 claims description 6
- BFPSDSIWYFKGBC-UHFFFAOYSA-N chlorotrianisene Chemical compound C1=CC(OC)=CC=C1C(Cl)=C(C=1C=CC(OC)=CC=1)C1=CC=C(OC)C=C1 BFPSDSIWYFKGBC-UHFFFAOYSA-N 0.000 claims description 5
- 238000004090 dissolution Methods 0.000 claims description 5
- 230000007613 environmental effect Effects 0.000 claims description 5
- 230000008014 freezing Effects 0.000 claims description 5
- 238000007710 freezing Methods 0.000 claims description 5
- 230000002163 immunogen Effects 0.000 claims description 5
- 210000002381 plasma Anatomy 0.000 claims description 5
- 238000012545 processing Methods 0.000 claims description 5
- 238000010257 thawing Methods 0.000 claims description 5
- 206010061218 Inflammation Diseases 0.000 claims description 4
- 230000000845 anti-microbial effect Effects 0.000 claims description 4
- 230000004054 inflammatory process Effects 0.000 claims description 4
- 230000002401 inhibitory effect Effects 0.000 claims description 4
- 241001465754 Metazoa Species 0.000 claims description 3
- 241001529936 Murinae Species 0.000 claims description 3
- 230000007115 recruitment Effects 0.000 claims description 3
- 102100031111 Disintegrin and metalloproteinase domain-containing protein 17 Human genes 0.000 claims 4
- 101000777461 Homo sapiens Disintegrin and metalloproteinase domain-containing protein 17 Proteins 0.000 claims 4
- 238000002360 preparation method Methods 0.000 claims 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract description 37
- 230000000855 fungicidal effect Effects 0.000 abstract description 3
- 230000002051 biphasic effect Effects 0.000 abstract description 2
- 230000001524 infective effect Effects 0.000 abstract description 2
- 230000001681 protective effect Effects 0.000 abstract description 2
- 230000001483 mobilizing effect Effects 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 description 46
- 108700017106 rhesus-theta-defensin-1 Proteins 0.000 description 24
- 229940024606 amino acid Drugs 0.000 description 23
- 229940121375 antifungal agent Drugs 0.000 description 23
- BEOLWJVNPROZQJ-AQSKNYQYSA-N rtd-1 Chemical compound C([C@@H]1NC(=O)CNC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@@H]2CSSC[C@H](NC1=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@H]1CSSC[C@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]3CSSC[C@@H](C(N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@H](C(=O)N3)C(C)C)=O)NC(=O)[C@H](CC(C)C)NC1=O)C(=O)N[C@H](C(N2)=O)[C@@H](C)CC)C1=CC=CC=C1 BEOLWJVNPROZQJ-AQSKNYQYSA-N 0.000 description 22
- RFHAOTPXVQNOHP-UHFFFAOYSA-N fluconazole Chemical compound C1=NC=NN1CC(C=1C(=CC(F)=CC=1)F)(O)CN1C=NC=N1 RFHAOTPXVQNOHP-UHFFFAOYSA-N 0.000 description 19
- 229960004884 fluconazole Drugs 0.000 description 19
- 238000001727 in vivo Methods 0.000 description 18
- 102000004196 processed proteins & peptides Human genes 0.000 description 18
- 229940079593 drug Drugs 0.000 description 15
- OBMZMSLWNNWEJA-XNCRXQDQSA-N C1=CC=2C(C[C@@H]3NC(=O)[C@@H](NC(=O)[C@H](NC(=O)N(CC#CCN(CCCC[C@H](NC(=O)[C@@H](CC4=CC=CC=C4)NC3=O)C(=O)N)CC=C)NC(=O)[C@@H](N)C)CC3=CNC4=C3C=CC=C4)C)=CNC=2C=C1 Chemical compound C1=CC=2C(C[C@@H]3NC(=O)[C@@H](NC(=O)[C@H](NC(=O)N(CC#CCN(CCCC[C@H](NC(=O)[C@@H](CC4=CC=CC=C4)NC3=O)C(=O)N)CC=C)NC(=O)[C@@H](N)C)CC3=CNC4=C3C=CC=C4)C)=CNC=2C=C1 OBMZMSLWNNWEJA-XNCRXQDQSA-N 0.000 description 13
- 241000222122 Candida albicans Species 0.000 description 13
- VZQHRKZCAZCACO-PYJNHQTQSA-N (2s)-2-[[(2s)-2-[2-[[(2s)-2-[[(2s)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]propanoyl]amino]prop-2-enoylamino]-3-methylbutanoyl]amino]propanoic acid Chemical compound OC(=O)[C@H](C)NC(=O)[C@H](C(C)C)NC(=O)C(=C)NC(=O)[C@H](C)NC(=O)[C@@H](N)CCCNC(N)=N VZQHRKZCAZCACO-PYJNHQTQSA-N 0.000 description 12
- 241000699670 Mus sp. Species 0.000 description 12
- 150000001875 compounds Chemical class 0.000 description 11
- 230000007774 longterm Effects 0.000 description 10
- 230000009885 systemic effect Effects 0.000 description 10
- 238000000338 in vitro Methods 0.000 description 8
- 208000015181 infectious disease Diseases 0.000 description 8
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 7
- 238000009472 formulation Methods 0.000 description 6
- 230000002538 fungal effect Effects 0.000 description 6
- 244000053095 fungal pathogen Species 0.000 description 6
- 230000001717 pathogenic effect Effects 0.000 description 6
- 239000011780 sodium chloride Substances 0.000 description 6
- 108010020326 Caspofungin Proteins 0.000 description 5
- 108010002069 Defensins Proteins 0.000 description 5
- 102000000541 Defensins Human genes 0.000 description 5
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 5
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 5
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 description 5
- JYIKNQVWKBUSNH-WVDDFWQHSA-N caspofungin Chemical compound C1([C@H](O)[C@@H](O)[C@H]2C(=O)N[C@H](C(=O)N3CC[C@H](O)[C@H]3C(=O)N[C@H](NCCN)[C@H](O)C[C@@H](C(N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)N2)[C@@H](C)O)=O)NC(=O)CCCCCCCC[C@@H](C)C[C@@H](C)CC)[C@H](O)CCN)=CC=C(O)C=C1 JYIKNQVWKBUSNH-WVDDFWQHSA-N 0.000 description 5
- 229960003034 caspofungin Drugs 0.000 description 5
- 230000000052 comparative effect Effects 0.000 description 5
- 235000004279 alanine Nutrition 0.000 description 4
- 239000012642 immune effector Substances 0.000 description 4
- 229940121354 immunomodulator Drugs 0.000 description 4
- 235000018102 proteins Nutrition 0.000 description 4
- 102000004169 proteins and genes Human genes 0.000 description 4
- 108090000623 proteins and genes Proteins 0.000 description 4
- 239000003381 stabilizer Substances 0.000 description 4
- 208000017667 Chronic Disease Diseases 0.000 description 3
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 description 3
- 239000006146 Roswell Park Memorial Institute medium Substances 0.000 description 3
- 230000000840 anti-viral effect Effects 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 230000003115 biocidal effect Effects 0.000 description 3
- 230000004071 biological effect Effects 0.000 description 3
- 230000037396 body weight Effects 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 238000011161 development Methods 0.000 description 3
- 230000028993 immune response Effects 0.000 description 3
- 230000002757 inflammatory effect Effects 0.000 description 3
- 238000001802 infusion Methods 0.000 description 3
- 238000007912 intraperitoneal administration Methods 0.000 description 3
- 229960000310 isoleucine Drugs 0.000 description 3
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 230000007246 mechanism Effects 0.000 description 3
- 230000009467 reduction Effects 0.000 description 3
- 230000002829 reductive effect Effects 0.000 description 3
- 230000004044 response Effects 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 108010034266 theta-defensin Proteins 0.000 description 3
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 description 2
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 description 2
- 102000009027 Albumins Human genes 0.000 description 2
- 108010088751 Albumins Proteins 0.000 description 2
- 241000222120 Candida <Saccharomycetales> Species 0.000 description 2
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 2
- 108010049047 Echinocandins Proteins 0.000 description 2
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 description 2
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 description 2
- 241000282560 Macaca mulatta Species 0.000 description 2
- 229930195725 Mannitol Natural products 0.000 description 2
- 101100330292 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) cys-12 gene Proteins 0.000 description 2
- 101100386053 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) cys-3 gene Proteins 0.000 description 2
- 229930006000 Sucrose Natural products 0.000 description 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 2
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 description 2
- 230000001154 acute effect Effects 0.000 description 2
- 125000003295 alanine group Chemical group N[C@@H](C)C(=O)* 0.000 description 2
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 description 2
- 238000010171 animal model Methods 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 230000003110 anti-inflammatory effect Effects 0.000 description 2
- 150000001720 carbohydrates Chemical class 0.000 description 2
- 235000014633 carbohydrates Nutrition 0.000 description 2
- 238000000576 coating method Methods 0.000 description 2
- 230000008482 dysregulation Effects 0.000 description 2
- 230000001408 fungistatic effect Effects 0.000 description 2
- 230000002519 immonomodulatory effect Effects 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 238000010255 intramuscular injection Methods 0.000 description 2
- 239000007927 intramuscular injection Substances 0.000 description 2
- 239000000594 mannitol Substances 0.000 description 2
- 235000010355 mannitol Nutrition 0.000 description 2
- 230000000737 periodic effect Effects 0.000 description 2
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 2
- 230000003389 potentiating effect Effects 0.000 description 2
- 230000000069 prophylactic effect Effects 0.000 description 2
- 230000035939 shock Effects 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 238000007920 subcutaneous administration Methods 0.000 description 2
- 238000006467 substitution reaction Methods 0.000 description 2
- 239000005720 sucrose Substances 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 230000004580 weight loss Effects 0.000 description 2
- NHBKXEKEPDILRR-UHFFFAOYSA-N 2,3-bis(butanoylsulfanyl)propyl butanoate Chemical compound CCCC(=O)OCC(SC(=O)CCC)CSC(=O)CCC NHBKXEKEPDILRR-UHFFFAOYSA-N 0.000 description 1
- 208000023275 Autoimmune disease Diseases 0.000 description 1
- 238000011725 BALB/c mouse Methods 0.000 description 1
- 241000675278 Candida albicans SC5314 Species 0.000 description 1
- 206010007134 Candida infections Diseases 0.000 description 1
- 241000282693 Cercopithecidae Species 0.000 description 1
- BWGNESOTFCXPMA-UHFFFAOYSA-N Dihydrogen disulfide Chemical compound SS BWGNESOTFCXPMA-UHFFFAOYSA-N 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 description 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 description 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 description 1
- 108090001005 Interleukin-6 Proteins 0.000 description 1
- 239000004472 Lysine Substances 0.000 description 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
- 206010029803 Nosocomial infection Diseases 0.000 description 1
- 241000282520 Papio Species 0.000 description 1
- 101710176384 Peptide 1 Proteins 0.000 description 1
- 241001238303 Turdus fuscater Species 0.000 description 1
- 208000036142 Viral infection Diseases 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 108050007802 alpha-defensin Proteins 0.000 description 1
- 239000002260 anti-inflammatory agent Substances 0.000 description 1
- 229940124599 anti-inflammatory drug Drugs 0.000 description 1
- 239000003429 antifungal agent Substances 0.000 description 1
- 229940124572 antihypotensive agent Drugs 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 150000003851 azoles Chemical class 0.000 description 1
- 108050002883 beta-defensin Proteins 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000001815 biotherapy Methods 0.000 description 1
- 229940095731 candida albicans Drugs 0.000 description 1
- 208000017773 candidemia Diseases 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 230000001186 cumulative effect Effects 0.000 description 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 230000007123 defense Effects 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 238000012217 deletion Methods 0.000 description 1
- 230000037430 deletion Effects 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 210000004392 genitalia Anatomy 0.000 description 1
- 230000005182 global health Effects 0.000 description 1
- 125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000036737 immune function Effects 0.000 description 1
- 208000027866 inflammatory disease Diseases 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 239000002054 inoculum Substances 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 239000007928 intraperitoneal injection Substances 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 230000002147 killing effect Effects 0.000 description 1
- 238000010150 least significant difference test Methods 0.000 description 1
- 238000009630 liquid culture Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 208000004235 neutropenia Diseases 0.000 description 1
- 210000000440 neutrophil Anatomy 0.000 description 1
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 239000013610 patient sample Substances 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 230000036470 plasma concentration Effects 0.000 description 1
- 150000004291 polyenes Chemical class 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 206010039073 rheumatoid arthritis Diseases 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 230000001052 transient effect Effects 0.000 description 1
- 239000005526 vasoconstrictor agent Substances 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4723—Cationic antimicrobial peptides, e.g. defensins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063044943P | 2020-06-26 | 2020-06-26 | |
| US63/044,943 | 2020-06-26 | ||
| PCT/US2021/039129 WO2021263126A1 (en) | 2020-06-26 | 2021-06-25 | Compositions and methods for treatment of fungal infections |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3187332A1 true CA3187332A1 (en) | 2021-12-30 |
Family
ID=79032412
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3187332A Pending CA3187332A1 (en) | 2020-06-26 | 2021-06-25 | Compositions and methods for treatment of fungal infections |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US12012440B2 (zh) |
| EP (1) | EP4172178A1 (zh) |
| JP (1) | JP2023534619A (zh) |
| KR (1) | KR20230030643A (zh) |
| CN (1) | CN115776985A (zh) |
| AU (1) | AU2021294340A1 (zh) |
| BR (1) | BR112022026421A2 (zh) |
| CA (1) | CA3187332A1 (zh) |
| IL (1) | IL299481A (zh) |
| MX (1) | MX2022016239A (zh) |
| WO (1) | WO2021263126A1 (zh) |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6335318B1 (en) | 1999-05-10 | 2002-01-01 | The Regents Of The University Of California | Antimicrobial theta defensins and methods of using same |
| US7119070B2 (en) * | 2002-04-30 | 2006-10-10 | The Regents Of The University Of California | Antimicrobial theta defensins, analogs thereof, and methods of use |
| CA2837858C (en) * | 2011-06-02 | 2022-05-03 | The Regents Of The University Of California | Blockade of inflammatory proteases with theta - defensins |
| ES2710973T3 (es) | 2014-08-29 | 2019-04-29 | Ceinge Biotecnologie Avanzate S C A R L | Análogos de las defensinas beta cíclicas para el tratamiento de infecciones |
-
2021
- 2021-06-25 CN CN202180045473.1A patent/CN115776985A/zh active Pending
- 2021-06-25 BR BR112022026421A patent/BR112022026421A2/pt unknown
- 2021-06-25 WO PCT/US2021/039129 patent/WO2021263126A1/en unknown
- 2021-06-25 AU AU2021294340A patent/AU2021294340A1/en active Pending
- 2021-06-25 US US17/358,828 patent/US12012440B2/en active Active
- 2021-06-25 IL IL299481A patent/IL299481A/en unknown
- 2021-06-25 KR KR1020237002995A patent/KR20230030643A/ko unknown
- 2021-06-25 MX MX2022016239A patent/MX2022016239A/es unknown
- 2021-06-25 EP EP21828841.3A patent/EP4172178A1/en active Pending
- 2021-06-25 JP JP2022580112A patent/JP2023534619A/ja active Pending
- 2021-06-25 CA CA3187332A patent/CA3187332A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US12012440B2 (en) | 2024-06-18 |
| US20210403523A1 (en) | 2021-12-30 |
| KR20230030643A (ko) | 2023-03-06 |
| JP2023534619A (ja) | 2023-08-10 |
| AU2021294340A1 (en) | 2023-02-02 |
| BR112022026421A2 (pt) | 2023-04-18 |
| MX2022016239A (es) | 2023-02-27 |
| CN115776985A (zh) | 2023-03-10 |
| WO2021263126A1 (en) | 2021-12-30 |
| EP4172178A1 (en) | 2023-05-03 |
| IL299481A (en) | 2023-02-01 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2799706T3 (es) | Lipopéptidos de alta pureza, micelas de lipopéptidos y procesos para preparar los mismos | |
| ES2264198T3 (es) | Composiciones y metodos para tratar infecciones utilizando peptidos cationicos a solas o en combinacion con antibioticos. | |
| AU2019222918B2 (en) | Antimicrobial peptides and methods of use thereof | |
| ES2532392T3 (es) | Péptidos antimicrobianos | |
| ES2661860T3 (es) | Péptido antibiótico y método de su preparación, y aplicación del mismo | |
| CN106232616A (zh) | 两亲性合成抗菌肽、其药物组合物及其用途 | |
| US20230072433A1 (en) | Compositions and methods for treatment of fungal infections | |
| KR101444261B1 (ko) | 왕지네로부터 분리한 신규 스콜로펜드라신ⅰ펩타이드 및 그의 조성물 | |
| CN103391786A (zh) | 作为抗糖尿病肽的载脂蛋白a-iv | |
| US12012440B2 (en) | Compositions and methods for treatment of fungal infections | |
| CN113164390A (zh) | 用于增强阳离子大环肽的全身递送能力、耐受性和效力的组合物和方法 | |
| TW202228764A (zh) | Ｇｌｐ－１／ｇｌｐ－２雙重促效劑之醫藥組合物 | |
| US8936782B2 (en) | Interferon beta as antibacterial agents | |
| CN1220700C (zh) | 金葡菌毒力刺激因子抑制肽及其应用 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20221215 |
|
| EEER | Examination request |
Effective date: 20221215 |
|
| EEER | Examination request |
Effective date: 20221215 |
|
| EEER | Examination request |
Effective date: 20221215 |
|
| EEER | Examination request |
Effective date: 20221215 |
|
| EEER | Examination request |
Effective date: 20221215 |