CA3179596A1 - Crystalline forms of omadacycline, methods of synthesis thereof and methods of use thereof - Google Patents
Crystalline forms of omadacycline, methods of synthesis thereof and methods of use thereof Download PDFInfo
- Publication number
- CA3179596A1 CA3179596A1 CA3179596A CA3179596A CA3179596A1 CA 3179596 A1 CA3179596 A1 CA 3179596A1 CA 3179596 A CA3179596 A CA 3179596A CA 3179596 A CA3179596 A CA 3179596A CA 3179596 A1 CA3179596 A1 CA 3179596A1
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- Prior art keywords
- omadacycline
- peak
- approximately
- freebase
- hplc
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C309/29—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings
- C07C309/30—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings of six-membered aromatic rings substituted by alkyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/22—Separation; Purification; Stabilisation; Use of additives
- C07C231/24—Separation; Purification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
- C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/40—Ortho- or ortho- and peri-condensed systems containing four condensed rings
- C07C2603/42—Ortho- or ortho- and peri-condensed systems containing four condensed rings containing only six-membered rings
- C07C2603/44—Naphthacenes; Hydrogenated naphthacenes
- C07C2603/46—1,4,4a,5,5a,6,11,12a- Octahydronaphthacenes, e.g. tetracyclines
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063037807P | 2020-06-11 | 2020-06-11 | |
| US63/037,807 | 2020-06-11 | ||
| PCT/US2021/036977 WO2021252876A1 (en) | 2020-06-11 | 2021-06-11 | Crystalline forms of omadacycline, methods of synthesis thereof and methods of use thereof |
Publications (1)
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|---|---|
| CA3179596A1 true CA3179596A1 (en) | 2021-12-16 |
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| CA3179596A Pending CA3179596A1 (en) | 2020-06-11 | 2021-06-11 | Crystalline forms of omadacycline, methods of synthesis thereof and methods of use thereof |
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| Country | Link |
|---|---|
| US (1) | US20230357135A1 (de) |
| EP (1) | EP4165016A4 (de) |
| JP (1) | JP2023530415A (de) |
| CN (1) | CN115667210A (de) |
| AU (1) | AU2021288202A1 (de) |
| CA (1) | CA3179596A1 (de) |
| WO (1) | WO2021252876A1 (de) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4289419A1 (de) * | 2022-06-11 | 2023-12-13 | Gufic Biosciences Limited | Gefriergetrocknete parenterale zusammensetzung von oomadacyclintosylat mit verbesserter stabilität |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010525069A (ja) * | 2007-04-27 | 2010-07-22 | パラテック ファーマシューティカルズ インコーポレイテッド | アミノアルキルテトラサイクリン化合物の合成方法および精製方法 |
| WO2009111064A2 (en) * | 2008-03-05 | 2009-09-11 | Paratek Pharmaceuticals, Inc. | Minocycline compounds and methods of use thereof |
| TW202021946A (zh) * | 2008-05-23 | 2020-06-16 | 美商派洛泰克藥物股份有限公司 | 四環素化合物之甲苯磺酸鹽及同素異形體 |
| BR112018069303A2 (pt) * | 2016-03-24 | 2019-01-22 | Paratek Pharm Innc | método para tratamento de uma infecção |
| KR102205843B1 (ko) * | 2016-06-22 | 2021-01-22 | 케이비피 바이오사이언시즈 씨오., 엘티디. | 9-아미노메틸 치환된 테트라사이클린 화합물의 결정형 및 그것의 제조 방법 |
| MX2021002503A (es) * | 2018-09-04 | 2021-06-15 | Paratek Pharm Innc | Métodos de tratamiento de infecciones micobacterianas usando compuestos de tetraciclina. |
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- 2021-06-11 AU AU2021288202A patent/AU2021288202A1/en active Pending
- 2021-06-11 CA CA3179596A patent/CA3179596A1/en active Pending
- 2021-06-11 US US18/009,670 patent/US20230357135A1/en active Pending
- 2021-06-11 CN CN202180041465.XA patent/CN115667210A/zh active Pending
- 2021-06-11 JP JP2022576027A patent/JP2023530415A/ja active Pending
- 2021-06-11 WO PCT/US2021/036977 patent/WO2021252876A1/en unknown
- 2021-06-11 EP EP21822182.8A patent/EP4165016A4/de active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4289419A1 (de) * | 2022-06-11 | 2023-12-13 | Gufic Biosciences Limited | Gefriergetrocknete parenterale zusammensetzung von oomadacyclintosylat mit verbesserter stabilität |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2021252876A1 (en) | 2021-12-16 |
| AU2021288202A1 (en) | 2022-12-08 |
| JP2023530415A (ja) | 2023-07-18 |
| EP4165016A1 (de) | 2023-04-19 |
| EP4165016A4 (de) | 2024-07-10 |
| US20230357135A1 (en) | 2023-11-09 |
| CN115667210A (zh) | 2023-01-31 |
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