CA3172777A1 - Compositions for colon cleansing and the treatment of gastrointestinal disorders - Google Patents

Compositions for colon cleansing and the treatment of gastrointestinal disorders

Info

Publication number
CA3172777A1
CA3172777A1 CA3172777A CA3172777A CA3172777A1 CA 3172777 A1 CA3172777 A1 CA 3172777A1 CA 3172777 A CA3172777 A CA 3172777A CA 3172777 A CA3172777 A CA 3172777A CA 3172777 A1 CA3172777 A1 CA 3172777A1
Authority
CA
Canada
Prior art keywords
cys
seq
tyr
leu
asn
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3172777A
Other languages
English (en)
French (fr)
Inventor
Mark G. Currie
Robert SOLINGA
Christopher Leitheiser
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ironwood Pharmaceuticals Inc
Original Assignee
Ironwood Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ironwood Pharmaceuticals Inc filed Critical Ironwood Pharmaceuticals Inc
Publication of CA3172777A1 publication Critical patent/CA3172777A1/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10—Peptides having 12 to 20 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0031—Rectum, anus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02—Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Endocrinology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Urology & Nephrology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA3172777A 2015-05-01 2016-04-29 Compositions for colon cleansing and the treatment of gastrointestinal disorders Pending CA3172777A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562156077P 2015-05-01 2015-05-01
US62/156,077 2015-05-01
CA2984437A CA2984437C (en) 2015-05-01 2016-04-29 COMPOSITION FOR COLON CLEANSING AND THE TREATMENT OF GASTROINTESTINAL DISORDERS

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA2984437A Division CA2984437C (en) 2015-05-01 2016-04-29 COMPOSITION FOR COLON CLEANSING AND THE TREATMENT OF GASTROINTESTINAL DISORDERS

Publications (1)

Publication Number Publication Date
CA3172777A1 true CA3172777A1 (en) 2016-11-10

Family

ID=55953439

Family Applications (2)

Application Number Title Priority Date Filing Date
CA3172777A Pending CA3172777A1 (en) 2015-05-01 2016-04-29 Compositions for colon cleansing and the treatment of gastrointestinal disorders
CA2984437A Active CA2984437C (en) 2015-05-01 2016-04-29 COMPOSITION FOR COLON CLEANSING AND THE TREATMENT OF GASTROINTESTINAL DISORDERS

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA2984437A Active CA2984437C (en) 2015-05-01 2016-04-29 COMPOSITION FOR COLON CLEANSING AND THE TREATMENT OF GASTROINTESTINAL DISORDERS

Country Status (23)

Country Link
US (2) US10618938B2 (https=)
EP (2) EP3288578B8 (https=)
JP (5) JP6930919B2 (https=)
KR (2) KR20250042844A (https=)
CN (2) CN108040482B (https=)
CA (2) CA3172777A1 (https=)
CY (1) CY1126031T1 (https=)
DK (1) DK3288578T5 (https=)
EA (1) EA201792401A1 (https=)
ES (1) ES2947591T3 (https=)
FI (1) FI3288578T3 (https=)
HR (1) HRP20230381T1 (https=)
HU (1) HUE061954T2 (https=)
LT (1) LT3288578T (https=)
MA (1) MA41985B1 (https=)
MD (1) MD3288578T2 (https=)
MX (2) MX2017013928A (https=)
PL (1) PL3288578T3 (https=)
PT (1) PT3288578T (https=)
RS (1) RS64160B1 (https=)
SI (1) SI3288578T1 (https=)
SM (1) SMT202300114T1 (https=)
WO (1) WO2016178979A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2947591T3 (es) * 2015-05-01 2023-08-11 Ironwood Pharmaceuticals Inc Composiciones para la limpieza del colon y el tratamiento de trastornos gastrointestinales
EP4067368A1 (en) 2016-06-01 2022-10-05 Athira Pharma, Inc. Compounds
IL312992A (en) * 2021-11-24 2024-07-01 Ironwood Pharmaceuticals Inc A synthetic process for the production of modified GCC receptor agonists
CN118696053A (zh) * 2021-11-24 2024-09-24 硬木药品公司 用于产生修饰的gcc受体激动剂的合成方法
IL313184A (en) * 2021-11-29 2024-07-01 Ironwood Pharmaceuticals Inc Pharmaceutical compositions for the treatment of visceral pain
WO2026050206A1 (en) * 2024-08-27 2026-03-05 Ironwood Pharmaceuticals, Inc. Combinations of glp-1 and guanylate cyclase c (gc-c) receptor agonists

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH689139A5 (de) 1995-04-03 1998-10-30 Cerbios Pharma Sa Verfahren zur Herstellung einer liposomalen, in Wasser dispergierbaren, oral zu verabreichenden, festen, trockenen therapeutischen Formulierung.
US5912014A (en) 1996-03-15 1999-06-15 Unigene Laboratories, Inc. Oral salmon calcitonin pharmaceutical products
SG168407A1 (en) * 2003-01-28 2011-02-28 Ironwood Pharmaceuticals Inc Methods and compositions for the treatment of gastrointestinal disorders
US7494979B2 (en) * 2003-06-13 2009-02-24 Ironwood Pharmaceuticals, Inc. Method for treating congestive heart failure and other disorders
EP1940441A4 (en) * 2005-08-19 2010-01-27 Ironwood Pharmaceuticals Inc COMPOSITIONS AND METHODS FOR TREATING GASTROINTESTINAL DISORDERS
WO2010025510A1 (en) * 2008-09-03 2010-03-11 Xenome Ltd Libraries of peptide conjugates and methods for making them
US8933030B2 (en) * 2010-02-17 2015-01-13 Ironwwod Pharmaceuticals, Inc. Treatments for gastrointestinal disorders
ES2664873T3 (es) * 2011-03-01 2018-04-23 Synergy Pharmaceuticals Inc. Proceso de preparación de agonistas de guanilato ciclasa C
US9545446B2 (en) * 2013-02-25 2017-01-17 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase and their uses
SI3004138T1 (sl) * 2013-06-05 2024-07-31 Bausch Health Ireland Limited Ultra čisti agonisti gvanilat ciklaze C, postopek za njihovo pripravo in uporabo
WO2016015055A1 (en) * 2014-07-25 2016-01-28 Ironwood Pharmaceuticals, Inc. Colon cleansing compositions
ES2947591T3 (es) * 2015-05-01 2023-08-11 Ironwood Pharmaceuticals Inc Composiciones para la limpieza del colon y el tratamiento de trastornos gastrointestinales

Also Published As

Publication number Publication date
DK3288578T3 (da) 2023-05-01
MA41985A (fr) 2018-03-07
MX2017013928A (es) 2018-01-15
MA41985B1 (fr) 2023-04-28
US10618938B2 (en) 2020-04-14
EP4218789A3 (en) 2023-09-27
EA201792401A1 (ru) 2018-05-31
US20180148476A1 (en) 2018-05-31
CN108040482A (zh) 2018-05-15
US20240199697A1 (en) 2024-06-20
MX2022013283A (es) 2022-12-13
CA2984437C (en) 2025-11-18
EP3288578B1 (en) 2023-03-15
KR102783759B1 (ko) 2025-03-21
EP3288578A1 (en) 2018-03-07
PL3288578T3 (pl) 2023-08-14
CA2984437A1 (en) 2016-11-10
HRP20230381T1 (hr) 2023-07-07
JP2018519254A (ja) 2018-07-19
JP6930919B2 (ja) 2021-09-01
JP2022121734A (ja) 2022-08-19
ES2947591T3 (es) 2023-08-11
HUE061954T2 (hu) 2023-09-28
PT3288578T (pt) 2023-03-28
LT3288578T (lt) 2023-04-25
EP3288578B8 (en) 2023-03-29
RS64160B1 (sr) 2023-05-31
KR20250042844A (ko) 2025-03-27
BR112017023539A2 (pt) 2018-08-14
SMT202300114T1 (it) 2023-05-12
JP2024015335A (ja) 2024-02-01
CY1126031T1 (el) 2023-11-15
MD3288578T2 (ro) 2023-08-31
FI3288578T3 (fi) 2023-05-03
CN108040482B (zh) 2022-03-29
CN114716514A (zh) 2022-07-08
KR20180005675A (ko) 2018-01-16
JP2025169325A (ja) 2025-11-12
SI3288578T1 (sl) 2023-07-31
JP2020203954A (ja) 2020-12-24
DK3288578T5 (da) 2024-10-07
EP4218789A2 (en) 2023-08-02
WO2016178979A1 (en) 2016-11-10

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