CA3164819A1 - Apparatus for maintenance of harvested hearts for transplanting - Google Patents

Apparatus for maintenance of harvested hearts for transplanting

Info

Publication number
CA3164819A1
CA3164819A1 CA3164819A CA3164819A CA3164819A1 CA 3164819 A1 CA3164819 A1 CA 3164819A1 CA 3164819 A CA3164819 A CA 3164819A CA 3164819 A CA3164819 A CA 3164819A CA 3164819 A1 CA3164819 A1 CA 3164819A1
Authority
CA
Canada
Prior art keywords
heart
perfusate
pump
flow
module
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3164819A
Other languages
English (en)
Inventor
Darren FREED
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Transmedics Inc
Original Assignee
Tevosol Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tevosol Inc filed Critical Tevosol Inc
Publication of CA3164819A1 publication Critical patent/CA3164819A1/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/14—Mechanical aspects of preservation; Apparatus or containers therefor
    • A01N1/142—Apparatus
    • A01N1/143—Apparatus for organ perfusion
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/14—Mechanical aspects of preservation; Apparatus or containers therefor
    • A01N1/142—Apparatus
    • A01N1/144—Apparatus for temperature control, e.g. refrigerators or freeze-drying apparatus
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00—Preservation of bodies of humans or animals, or parts thereof
    • A01N1/10—Preservation of living parts
    • A01N1/14—Mechanical aspects of preservation; Apparatus or containers therefor
    • A01N1/146—Non-refrigerated containers specially adapted for transporting or storing living parts whilst preserving
    • A01N1/148—Non-refrigerated containers specially adapted for transporting or storing living parts whilst preserving with provisions specially adapted for transporting
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/24—Detecting, measuring or recording bioelectric or biomagnetic signals of the body or parts thereof
    • A61B5/316—Modalities, i.e. specific diagnostic methods
    • A61B5/318—Heart-related electrical modalities, e.g. electrocardiography [ECG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/362—Heart stimulators
    • A61N1/3621—Heart stimulators for treating or preventing abnormally high heart rate
    • A61N1/3622—Heart stimulators for treating or preventing abnormally high heart rate comprising two or more electrodes co-operating with different heart regions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/362—Heart stimulators
    • A61N1/3625—External stimulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/38—Applying electric currents by contact electrodes alternating or intermittent currents for producing shock effects
    • A61N1/39—Heart defibrillators
    • A61N1/3968—Constructional arrangements, e.g. casings

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Cardiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Environmental Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Dentistry (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Surgery (AREA)
  • Molecular Biology (AREA)
  • Medical Informatics (AREA)
  • Biophysics (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • External Artificial Organs (AREA)
  • Thermal Sciences (AREA)
  • Agricultural Machines (AREA)
CA3164819A 2014-03-26 2015-03-18 Apparatus for maintenance of harvested hearts for transplanting Pending CA3164819A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461970532P 2014-03-26 2014-03-26
US61/970,532 2014-03-26
CA2943633A CA2943633C (en) 2014-03-26 2015-03-18 Apparatus for maintenance of harvested hearts for transplanting

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA2943633A Division CA2943633C (en) 2014-03-26 2015-03-18 Apparatus for maintenance of harvested hearts for transplanting

Publications (1)

Publication Number Publication Date
CA3164819A1 true CA3164819A1 (en) 2015-10-01

Family

ID=54193814

Family Applications (2)

Application Number Title Priority Date Filing Date
CA3164819A Pending CA3164819A1 (en) 2014-03-26 2015-03-18 Apparatus for maintenance of harvested hearts for transplanting
CA2943633A Active CA2943633C (en) 2014-03-26 2015-03-18 Apparatus for maintenance of harvested hearts for transplanting

Family Applications After (1)

Application Number Title Priority Date Filing Date
CA2943633A Active CA2943633C (en) 2014-03-26 2015-03-18 Apparatus for maintenance of harvested hearts for transplanting

Country Status (9)

Country Link
US (2) US10327442B2 (https=)
EP (3) EP4023066B1 (https=)
CN (2) CN106659150B (https=)
AU (1) AU2015234580B2 (https=)
BR (1) BR112016021971B1 (https=)
CA (2) CA3164819A1 (https=)
DK (1) DK4023066T3 (https=)
ES (2) ES3036002T3 (https=)
WO (1) WO2015143552A1 (https=)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103931605B (zh) 2004-10-07 2015-11-18 特兰斯迈迪茨公司 用于活体外器官护理的系统和方法
US12010987B2 (en) 2004-10-07 2024-06-18 Transmedics, Inc. Systems and methods for ex-vivo organ care and for using lactate as an indication of donor organ status
US9078428B2 (en) 2005-06-28 2015-07-14 Transmedics, Inc. Systems, methods, compositions and solutions for perfusing an organ
US9457179B2 (en) 2007-03-20 2016-10-04 Transmedics, Inc. Systems for monitoring and applying electrical currents in an organ perfusion system
US8420380B2 (en) 2008-01-31 2013-04-16 Transmedics, Inc. Systems and methods for ex vivo lung care
US20130011823A1 (en) 2011-04-14 2013-01-10 Hassanein Waleed H Organ care solution for ex-vivo machine perfusion of donor lungs
EP4091446A1 (en) 2012-01-17 2022-11-23 Tevosol, Inc. Apparatus for testing, assessment, and maintenance of harvested hearts for transplanting
ES3036002T3 (en) 2014-03-26 2025-09-11 Transmedics Inc Apparatus for maintenance of harvested hearts for transplanting
JP2017518301A (ja) 2014-06-02 2017-07-06 トランスメディクス， インク．Ｔｒａｎｓｍｅｄｉｃｓ， Ｉｎｃ． ｅｘ−ｖｉｖｏでの臓器管理システム
CA3155169A1 (en) 2014-12-12 2016-06-16 Tevosol, Inc. Apparatus and method for organ perfusion
CA2997267A1 (en) 2015-09-09 2017-03-16 Transmedics, Inc. Aortic cannula for ex vivo organ care system
ES2968062T3 (es) 2016-05-30 2024-05-07 Transmedics Inc Aparato y método de ventilación pulmonar ex vivo con presión exterior variable
DE102016117901A1 (de) * 2016-09-22 2018-03-22 Technische Universität Dresden System und Verfahren zur extrakorporalen Perfusion von Organen
US20200120924A1 (en) * 2017-04-21 2020-04-23 University Health Network Method and system for ex-vivo heart perfusion
KR102764137B1 (ko) * 2019-09-11 2025-02-06 현대자동차주식회사 자율주행 차량용 제세동 시스템
EP4252536A1 (en) * 2022-04-01 2023-10-04 Medizinische Hochschule Hannover Perfusion system

Family Cites Families (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1988005261A1 (en) * 1987-01-16 1988-07-28 Tops Systems, Inc. Total organ perfusion system
US5157930A (en) 1991-04-22 1992-10-27 Mcghee Samuel C Organ preservation apparatus
US5217860A (en) * 1991-07-08 1993-06-08 The American National Red Cross Method for preserving organs for transplantation by vitrification
US5338662A (en) 1992-09-21 1994-08-16 Bio-Preserve Medical Corporation Organ perfusion device
DE19535781C2 (de) 1995-09-26 1999-11-11 Fraunhofer Ges Forschung Vorrichtung zur aktiven Strömungsunterstützung von Körperflüssigkeiten
US5716378A (en) * 1996-06-06 1998-02-10 Medtronic, Inc. Heart preservation and transportation apparatus and method employing low rate cardiac pacing for improved removal of catabolites from the myocardium
US5807737A (en) * 1996-07-26 1998-09-15 Schill Enterprises, Inc. Heart and lung support assembly
US8409846B2 (en) * 1997-09-23 2013-04-02 The United States Of America As Represented By The Department Of Veteran Affairs Compositions, methods and devices for maintaining an organ
US6100082A (en) * 1997-09-23 2000-08-08 Hassanein; Waleed H. Perfusion apparatus and method including chemical compositions for maintaining an organ
US6953655B1 (en) 1997-09-23 2005-10-11 The United States Of America As Represented By The Department Of Veterans Affairs Compositions, methods and devices for maintaining an organ
US7749693B2 (en) * 1998-09-29 2010-07-06 Lifeline Scientific, Inc. Method of determining that an organ is not suitable for transplantation and using it for testing substances
EP2308295A3 (en) * 1998-09-29 2011-05-25 Organ Recovery Systems, Inc. Apparatus for transporting an organ
US6977140B1 (en) 1998-09-29 2005-12-20 Organ Recovery Systems, Inc. Method for maintaining and/or restoring viability of organs
US7045279B1 (en) 1998-10-22 2006-05-16 Medtronic, Inc. Isolated perfused heart preparation and method of use
EP1181032A4 (en) * 1999-04-14 2004-08-25 Breonics Inc BLOOD METABOLIC SUPPORT SYSTEM FOR AN ORGAN OR TISSUE
US6582375B2 (en) 2001-10-11 2003-06-24 University Of Cincinnati System for study of global uni-or bi-ventricular function of an explanted, reperfused heart
EP1613153B1 (en) 2003-04-04 2021-06-02 Organ Recovery Systems, Inc. Methods and apparatus for perfusion, diagnosis, storage and/or transport of an organ or tissue
US8043854B2 (en) * 2003-05-15 2011-10-25 Waseda University Method of decellularizing tissues
NL1024022C2 (nl) * 2003-07-30 2005-02-01 Technologiestichting Stw Draagbare preservatie-inrichting voor een donororgaan.
DE10340487B4 (de) * 2003-09-03 2007-07-12 Technische Universität Dresden Perfusionskreislauf
US8741555B2 (en) 2004-05-14 2014-06-03 Organ Recovery Systems, Inc. Apparatus and method for perfusion and determining the viability of an organ
CN103931605B (zh) 2004-10-07 2015-11-18 特兰斯迈迪茨公司 用于活体外器官护理的系统和方法
US8304181B2 (en) * 2004-10-07 2012-11-06 Transmedics, Inc. Method for ex-vivo organ care and for using lactate as an indication of donor organ status
US20070048725A1 (en) * 2005-08-25 2007-03-01 Arrington Ben O'mar Machine perfusion of tissue grafts for transplantation
DE102005048625A1 (de) 2005-10-11 2007-04-12 Universität Leipzig System zur nicht-kardioplegischen Konservierung von Spenderherzen für die Transplantation
US7575856B2 (en) * 2005-10-28 2009-08-18 The United States Of America As Represented By The Department Of Veterans Affairs Compositions and methods for the evaluation and resuscitation of cadaveric hearts for transplant
EP2543249B1 (en) 2007-02-17 2018-05-23 President and Fellows of Harvard College Compositions and method for tissue preservation
EP2131650B1 (en) 2007-03-01 2017-11-29 Lifeline Scientific, Inc. Perfusion regulation
US8420380B2 (en) * 2008-01-31 2013-04-16 Transmedics, Inc. Systems and methods for ex vivo lung care
WO2010036726A1 (en) 2008-09-23 2010-04-01 Cedars-Sinai Medical Center Methods and apparatus for perfusion of an explanted donor heart
SE534527C2 (sv) 2009-09-24 2011-09-20 Vivoline Medical Ab Förfarande, anordning och vätska för behandling av ett hjärta efter uttagning
EP2750499B1 (en) 2011-09-02 2016-07-20 Organ Assist B.V. Apparatus, system and method for conditioning and preserving an organ from a donor
EP4091446A1 (en) 2012-01-17 2022-11-23 Tevosol, Inc. Apparatus for testing, assessment, and maintenance of harvested hearts for transplanting
CN102960335B (zh) * 2012-10-22 2013-12-25 同济大学附属上海市肺科医院 应用于无心跳供体肺移植中肺脏低温、通气序贯保存的装置
CA2913058C (en) * 2013-06-07 2019-09-17 Organ Transport Pty Ltd Organ perfusion system and device
ES3036002T3 (en) 2014-03-26 2025-09-11 Transmedics Inc Apparatus for maintenance of harvested hearts for transplanting
CN204682347U (zh) * 2014-12-04 2015-10-07 宋涂润 用于保存人体器官的常温灌注系统
CA3155169A1 (en) 2014-12-12 2016-06-16 Tevosol, Inc. Apparatus and method for organ perfusion

Also Published As

Publication number Publication date
EP3122180B1 (en) 2022-05-11
BR112016021971A2 (https=) 2017-08-15
DK4023066T3 (da) 2025-08-04
EP4023066A1 (en) 2022-07-06
CN113229273B (zh) 2023-01-31
CN106659150B (zh) 2021-06-01
CN113229273A (zh) 2021-08-10
US20190387736A1 (en) 2019-12-26
CA2943633C (en) 2023-06-20
AU2015234580B2 (en) 2018-11-15
US20170223950A1 (en) 2017-08-10
EP3122180A1 (en) 2017-02-01
ES3036002T3 (en) 2025-09-11
EP4023066B1 (en) 2025-06-25
EP4596032A2 (en) 2025-08-06
AU2015234580A1 (en) 2016-10-27
CN106659150A (zh) 2017-05-10
ES2916212T3 (es) 2022-06-29
EP3122180A4 (en) 2018-01-03
CA2943633A1 (en) 2015-10-01
WO2015143552A1 (en) 2015-10-01
BR112016021971B1 (pt) 2022-05-17
US10327442B2 (en) 2019-06-25
EP4596032A3 (en) 2025-11-26

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