CA3163886A1 - Dendrimer compositions and methods for drug delivery - Google Patents

Dendrimer compositions and methods for drug delivery

Info

Publication number
CA3163886A1
CA3163886A1 CA3163886A CA3163886A CA3163886A1 CA 3163886 A1 CA3163886 A1 CA 3163886A1 CA 3163886 A CA3163886 A CA 3163886A CA 3163886 A CA3163886 A CA 3163886A CA 3163886 A1 CA3163886 A1 CA 3163886A1
Authority
CA
Canada
Prior art keywords
composition
dendrimer
inhibitors
tumor
cancer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3163886A
Other languages
English (en)
French (fr)
Inventor
Jeffrey Cleland
Rishi SHARMA
Minghao SUN
Santiago APPIANI
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ashvattha Therapeutics Inc
Original Assignee
Ashvattha Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ashvattha Therapeutics Inc filed Critical Ashvattha Therapeutics Inc
Publication of CA3163886A1 publication Critical patent/CA3163886A1/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/595—Polyamides, e.g. nylon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
CA3163886A 2019-12-04 2020-12-04 Dendrimer compositions and methods for drug delivery Pending CA3163886A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962943705P 2019-12-04 2019-12-04
US62/943,705 2019-12-04
US202063108186P 2020-10-30 2020-10-30
US63/108,186 2020-10-30
PCT/US2020/063332 WO2021113651A2 (en) 2019-12-04 2020-12-04 Dendrimer compositions and methods for drug delivery

Publications (1)

Publication Number Publication Date
CA3163886A1 true CA3163886A1 (en) 2021-06-10

Family

ID=74104190

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3163886A Pending CA3163886A1 (en) 2019-12-04 2020-12-04 Dendrimer compositions and methods for drug delivery

Country Status (9)

Country Link
US (3) US20210170040A1 (https=)
EP (1) EP4069307A2 (https=)
JP (1) JP2023504286A (https=)
CN (1) CN115103689A (https=)
AU (1) AU2020397063A1 (https=)
CA (1) CA3163886A1 (https=)
IL (1) IL293604A (https=)
PH (1) PH12022551368A1 (https=)
WO (1) WO2021113651A2 (https=)

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* Cited by examiner, † Cited by third party
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JP7759322B2 (ja) 2019-12-04 2025-10-23 アシュバッタ セラピューティクス， インコーポレイテッド 眼に薬物送達するためのデンドリマー組成物および方法
PH12022552818A1 (en) 2020-04-24 2024-03-25 Ashvattha Therapeutics Inc Dendrimer compositions and methods for treatment of severe acute respiratory distress syndrome
US20230364244A1 (en) * 2020-07-17 2023-11-16 Ashvattha Therapeutics, Inc. Dendrimer compositions and methods for drug delivery to injured kidney
WO2022094327A1 (en) * 2020-10-30 2022-05-05 Ashvattha Therapeutics, Inc. Radiolabeled ether dendrimer conjugates for pet imaging and radiotherapy
US20240139107A1 (en) * 2021-03-08 2024-05-02 Transdermal Biotechnology, Inc. Dendrimer-n-acetyl-l-cysteine conjugates for treatment or prevention of aging skin or other indications
WO2022261504A1 (en) * 2021-06-10 2022-12-15 Ashvattha Therapeutics, Inc. Dendrimer conjugates and methods of use thereof
WO2023173124A1 (en) * 2022-03-10 2023-09-14 Cheng Kun Novel phosphoinositide 3-kinase (pi3k) inhibitor, compositions comprising the same, methods of making, and methods of treating a disease
WO2023183367A1 (en) * 2022-03-22 2023-09-28 Board Of Regents Of The University Of Nebraska Metformin nanoformulations and methods of use thereof
CN114796492B (zh) * 2022-05-12 2023-01-13 大连理工大学 一种超声驱动纳米声敏疫苗及其制备和应用
CN116196292B (zh) * 2023-02-16 2024-08-16 东华大学 一种靶向肽修饰的聚酰胺-胺树状大分子复合纳米材料及其制备方法
WO2025183982A1 (en) * 2024-02-28 2025-09-04 Washington State University Psma-targeted dendrimer nanoplatform for cancer detection and therapy
WO2025226820A1 (en) * 2024-04-23 2025-10-30 Ashvattha Therapeutics, Inc. Csf1r inhibitor dendrimer conjugates and uses thereof
CN118108799B (zh) * 2024-04-29 2024-07-12 内蒙古工业大学 基于DMXAA的含Se多肽药物及其制备方法和应用
WO2025259214A1 (en) 2024-06-14 2025-12-18 EGE Kimya San. ve Tic. A.S. Use of dendrimer compounds as anti-skinning agents
WO2025259215A1 (en) 2024-06-14 2025-12-18 EGE Kimya San. ve Tic. A.S. Use of dendrimer compounds as complexing ligands for metal activity enhancement
CN118846078A (zh) * 2024-07-02 2024-10-29 中国人民解放军空军军医大学 Ndrg2基因联合分子靶向抑制剂在制备肾细胞癌治疗药物中的应用

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US3878047A (en) 1973-02-02 1975-04-15 Upjohn Co Process for production of AT-125
US5087639A (en) 1988-11-02 1992-02-11 The Upjohn Company Preventing CNS toxicity of acivicin when used with four large neutral amino acids
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PL2214646T3 (pl) * 2007-10-05 2021-12-20 Wayne State University Dendrymery do przedłużonego uwalniania związków
CA2767163A1 (en) 2009-06-15 2010-12-23 Wayne State University Dendrimer based nanodevices for therapeutic and imaging purposes
EP2552458A4 (en) 2010-03-31 2014-08-27 Univ Wayne State INJECTABLE DENDRIMER HYDROGEL NANOPARTICLES
US9198973B2 (en) * 2013-06-17 2015-12-01 Fundacion Fraunhofer Chile Research PAMAM, spacer molecule and cafestol polymers
CA2946422C (en) * 2014-04-30 2019-03-05 The Johns Hopkins University Dendrimer compositions and their use in treatment of diseases of the eye
EA036983B1 (ru) * 2014-05-21 2021-01-22 АйСиДи-ТЕРАПЬЮТИКС ГМБХ Терапевтические конъюгаты с сульфатированными дендримерами для внутриклеточного нацеливания
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JP6342575B2 (ja) * 2014-08-13 2018-06-13 ザ・ジョンズ・ホプキンス・ユニバーシティー 脳腫瘍への選択的デンドリマー送達
JP6847848B2 (ja) * 2014-12-15 2021-03-24 ザ ジョーンズ ホプキンズ ユニバーシティＴｈｅ Ｊｏｈｎｓ Ｈｏｐｋｉｎｓ Ｕｎｉｖｅｒｓｉｔｙ スニチニブ製剤、及び緑内障の治療におけるその使用方法
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JP7759322B2 (ja) * 2019-12-04 2025-10-23 アシュバッタ セラピューティクス， インコーポレイテッド 眼に薬物送達するためのデンドリマー組成物および方法

Also Published As

Publication number Publication date
US20210170040A1 (en) 2021-06-10
US20230226199A1 (en) 2023-07-20
PH12022551368A1 (en) 2023-05-08
EP4069307A2 (en) 2022-10-12
AU2020397063A1 (en) 2022-07-07
JP2023504286A (ja) 2023-02-02
US20230372499A1 (en) 2023-11-23
IL293604A (en) 2022-08-01
WO2021113651A3 (en) 2021-08-26
CN115103689A (zh) 2022-09-23
WO2021113651A2 (en) 2021-06-10

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