CA3159624A1 - Topical compositions comprising irak4 inhibitors for use in treating dermatological conditions characterised by inflammation - Google Patents

Topical compositions comprising irak4 inhibitors for use in treating dermatological conditions characterised by inflammation

Info

Publication number
CA3159624A1
CA3159624A1 CA3159624A CA3159624A CA3159624A1 CA 3159624 A1 CA3159624 A1 CA 3159624A1 CA 3159624 A CA3159624 A CA 3159624A CA 3159624 A CA3159624 A CA 3159624A CA 3159624 A1 CA3159624 A1 CA 3159624A1
Authority
CA
Canada
Prior art keywords
group
optionally substituted
substituent
aromatic heterocyclic
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3159624A
Other languages
English (en)
French (fr)
Inventor
Jamie L. HARDEN
Hans E. J. HOFLAND
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dermira Inc
Original Assignee
Dermira Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dermira Inc filed Critical Dermira Inc
Publication of CA3159624A1 publication Critical patent/CA3159624A1/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
CA3159624A 2019-11-05 2020-11-05 Topical compositions comprising irak4 inhibitors for use in treating dermatological conditions characterised by inflammation Pending CA3159624A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962931132P 2019-11-05 2019-11-05
US62/931,132 2019-11-05
US202063046143P 2020-06-30 2020-06-30
US63/046,143 2020-06-30
PCT/US2020/059200 WO2021092239A1 (en) 2019-11-05 2020-11-05 Topical compositions comprising irak4 inhibitors for use in treating dermatological conditions characterised by inflammation

Publications (1)

Publication Number Publication Date
CA3159624A1 true CA3159624A1 (en) 2021-05-14

Family

ID=73654894

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3159624A Pending CA3159624A1 (en) 2019-11-05 2020-11-05 Topical compositions comprising irak4 inhibitors for use in treating dermatological conditions characterised by inflammation

Country Status (9)

Country Link
US (1) US20230125380A1 (https=)
EP (1) EP4054573A1 (https=)
JP (1) JP2023500707A (https=)
CN (2) CN118806758A (https=)
AU (1) AU2020380921A1 (https=)
BR (1) BR112022008610A2 (https=)
CA (1) CA3159624A1 (https=)
IL (1) IL292689A (https=)
WO (1) WO2021092239A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3186630A1 (en) * 2020-06-30 2022-01-06 Dermira, Inc. Irak4 inhibitors and topical uses thereof
CN118530374B (zh) * 2023-06-02 2025-11-04 东北农业大学 犬成纤维细胞生长因子21融合蛋白制备及其在治疗特应性皮炎中的用途

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105899505B (zh) 2013-11-08 2018-08-28 武田药品工业株式会社 用于治疗自身免疫病症的吡唑
BR112018000624A2 (pt) * 2015-07-15 2018-09-18 Aurigene Discovery Technologies Limited compostos de indazol e azaindazol como inibidores de irak-4
WO2017205762A1 (en) * 2016-05-27 2017-11-30 Pharmacyclics Llc Inhibitors of interleukin-1 receptor-associated kinase
EP3727428A1 (en) * 2017-12-20 2020-10-28 Translate Bio, Inc. Improved composition and methods for treatment of ornithine transcarbamylase deficiency
IL315310A (en) * 2017-12-26 2024-10-01 Kymera Therapeutics Inc Irak degraders and uses thereof
CA3186630A1 (en) * 2020-06-30 2022-01-06 Dermira, Inc. Irak4 inhibitors and topical uses thereof

Also Published As

Publication number Publication date
AU2020380921A1 (en) 2022-05-26
US20230125380A1 (en) 2023-04-27
JP2023500707A (ja) 2023-01-10
CN114929223A (zh) 2022-08-19
IL292689A (en) 2022-07-01
EP4054573A1 (en) 2022-09-14
CN118806758A (zh) 2024-10-22
BR112022008610A2 (pt) 2022-08-09
WO2021092239A1 (en) 2021-05-14

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