CA3159087A1 - Compositions that preferentially potentiate subtypes of gabaa receptors and methods of use thereof - Google Patents
Compositions that preferentially potentiate subtypes of gabaa receptors and methods of use thereofInfo
- Publication number
- CA3159087A1 CA3159087A1 CA3159087A CA3159087A CA3159087A1 CA 3159087 A1 CA3159087 A1 CA 3159087A1 CA 3159087 A CA3159087 A CA 3159087A CA 3159087 A CA3159087 A CA 3159087A CA 3159087 A1 CA3159087 A1 CA 3159087A1
- Authority
- CA
- Canada
- Prior art keywords
- disorder
- compound
- composition
- less
- gabaa
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Addiction (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Plant Substances (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962907763P | 2019-09-30 | 2019-09-30 | |
US62/907,763 | 2019-09-30 | ||
PCT/US2020/052167 WO2021067089A1 (en) | 2019-09-30 | 2020-09-23 | Compositions that preferentially potentiate subtypes of gabaa receptors and methods of use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
CA3159087A1 true CA3159087A1 (en) | 2021-04-08 |
Family
ID=75338529
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA3159087A Pending CA3159087A1 (en) | 2019-09-30 | 2020-09-23 | Compositions that preferentially potentiate subtypes of gabaa receptors and methods of use thereof |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP4135710A4 (zh) |
JP (1) | JP2022552788A (zh) |
KR (1) | KR20220103707A (zh) |
CN (1) | CN115087450A (zh) |
BR (1) | BR112022006085A2 (zh) |
CA (1) | CA3159087A1 (zh) |
IL (1) | IL291835A (zh) |
MX (1) | MX2022003823A (zh) |
WO (1) | WO2021067089A1 (zh) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP4161530A4 (en) * | 2020-06-08 | 2024-06-26 | Eliem Therapeutics (UK) Ltd | METHODS FOR TREATING FEMALE HEALTH CONDITIONS RELATED TO SEX HORMONES |
WO2024020953A1 (zh) * | 2022-07-28 | 2024-02-01 | 湖南科益新生物医药有限公司 | 治疗中枢神经系统疾病的甾体化合物及其制备方法、用途和药物组合物 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5939545A (en) * | 1994-02-14 | 1999-08-17 | Cocensys, Inc. | Method, compositions, and compounds for allosteric modulation of the gaba receptor by members of the androstane and pregnane series |
PT3498725T (pt) * | 2013-04-17 | 2021-09-09 | Sage Therapeutics Inc | Esteroides c21-n-pirazolilo 19-nor c3,3-dissubstituídos para uso em terapia |
WO2016061527A1 (en) * | 2014-10-16 | 2016-04-21 | Sage Therapeutics, Inc. | Compositions and methods for treating cns disorders |
CN109890392A (zh) * | 2016-10-14 | 2019-06-14 | 马瑞纳斯制药公司 | 施用神经类固醇以实现脑电图(eeg)爆发抑制的方法 |
WO2020210116A1 (en) * | 2019-04-08 | 2020-10-15 | Athenen Therapeutics, Inc. | Steroids with altered pharmacokinetic properties and methods of use thereof |
-
2020
- 2020-09-23 JP JP2022519997A patent/JP2022552788A/ja active Pending
- 2020-09-23 MX MX2022003823A patent/MX2022003823A/es unknown
- 2020-09-23 CN CN202080082811.4A patent/CN115087450A/zh active Pending
- 2020-09-23 KR KR1020227014562A patent/KR20220103707A/ko active Search and Examination
- 2020-09-23 BR BR112022006085A patent/BR112022006085A2/pt unknown
- 2020-09-23 WO PCT/US2020/052167 patent/WO2021067089A1/en unknown
- 2020-09-23 EP EP20872608.3A patent/EP4135710A4/en active Pending
- 2020-09-23 IL IL291835A patent/IL291835A/en unknown
- 2020-09-23 CA CA3159087A patent/CA3159087A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
EP4135710A4 (en) | 2023-12-06 |
IL291835A (en) | 2022-06-01 |
EP4135710A1 (en) | 2023-02-22 |
WO2021067089A1 (en) | 2021-04-08 |
BR112022006085A2 (pt) | 2023-03-14 |
CN115087450A (zh) | 2022-09-20 |
JP2022552788A (ja) | 2022-12-20 |
KR20220103707A (ko) | 2022-07-22 |
MX2022003823A (es) | 2022-08-17 |
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