CA3148278A1 - Substituted 2-morpholinopyridine derivatives as atr kinase inhibitors - Google Patents

Substituted 2-morpholinopyridine derivatives as atr kinase inhibitors Download PDF

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Publication number
CA3148278A1
CA3148278A1 CA3148278A CA3148278A CA3148278A1 CA 3148278 A1 CA3148278 A1 CA 3148278A1 CA 3148278 A CA3148278 A CA 3148278A CA 3148278 A CA3148278 A CA 3148278A CA 3148278 A1 CA3148278 A1 CA 3148278A1
Authority
CA
Canada
Prior art keywords
carcinoma
compound
leukemia
cancer
optionally substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3148278A
Other languages
English (en)
French (fr)
Inventor
Sheldon N. Crane
Vouy Linh Truong
Abbas ABDOLI
Jean-Francois Truchon
Cameron Black
Stephane Dorich
Lee Fader
Stephanie Lanoix
Paul Jones
Miguel St-Onge
Audrey PICARD
Cyrus M. LACBAY
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Repare Therapeutics Inc
Original Assignee
Repare Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/CA2019/051539 external-priority patent/WO2020087170A1/en
Application filed by Repare Therapeutics Inc filed Critical Repare Therapeutics Inc
Publication of CA3148278A1 publication Critical patent/CA3148278A1/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
CA3148278A 2019-07-22 2020-07-22 Substituted 2-morpholinopyridine derivatives as atr kinase inhibitors Pending CA3148278A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962877177P 2019-07-22 2019-07-22
US62/877,177 2019-07-22
CAPCT/CA2019/051539 2019-10-30
PCT/CA2019/051539 WO2020087170A1 (en) 2018-10-30 2019-10-30 Compounds, pharmaceutical compositions, and methods of preparing compounds and of their use as atr kinase inhibitors
PCT/CA2020/051014 WO2021012049A1 (en) 2019-07-22 2020-07-22 Substituted 2-morpholinopyridine derivatives as atr kinase inhibitors

Publications (1)

Publication Number Publication Date
CA3148278A1 true CA3148278A1 (en) 2021-01-28

Family

ID=74192632

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3148278A Pending CA3148278A1 (en) 2019-07-22 2020-07-22 Substituted 2-morpholinopyridine derivatives as atr kinase inhibitors

Country Status (16)

Country Link
US (1) US20220185809A1 (enExample)
EP (1) EP4003993A4 (enExample)
JP (2) JP7617076B2 (enExample)
KR (1) KR20220035925A (enExample)
CN (1) CN114174292B (enExample)
AU (1) AU2020317381A1 (enExample)
BR (1) BR112022000431A2 (enExample)
CA (1) CA3148278A1 (enExample)
CO (1) CO2022001853A2 (enExample)
CR (1) CR20220068A (enExample)
EC (1) ECSP22012347A (enExample)
IL (1) IL289763A (enExample)
MX (1) MX2022000854A (enExample)
PH (1) PH12022550156A1 (enExample)
UA (1) UA129807C2 (enExample)
WO (1) WO2021012049A1 (enExample)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2019373416A1 (en) 2018-10-30 2021-06-10 Repare Therapeutics Inc. Compounds, pharmaceutical compositions, and methods of preparing compounds and of their use as ATR kinase inhibitors
KR20220035925A (ko) * 2019-07-22 2022-03-22 리페어 세라퓨틱스 인크. Atr 키나제 억제제로서의 치환된 2-모르폴리노피리딘 유도체
EP4072551A4 (en) * 2019-12-11 2023-11-15 Repare Therapeutics Inc. USE OF ATR INHIBITORS IN COMBINATION WITH PARP INHIBITORS
JP2024516821A (ja) * 2021-04-28 2024-04-17 リペア セラピューティクス インコーポレイテッド 両アレル機能喪失型変異または遺伝子過剰発現変異を有するがんを治療する方法
MX2023014302A (es) * 2021-06-04 2024-02-28 Repare Therapeutics Inc Formas cristalinas, composiciones que contienen las mismas y métodos para su uso.
TW202321256A (zh) * 2021-07-27 2023-06-01 大陸商上海輝啟生物醫藥科技有限公司 ８－氧－３－氮雜雙環［３．２．１］辛烷類化合物或其鹽及其製備方法和用途
CN113856764B (zh) * 2021-10-29 2022-11-01 华中科技大学 一种过渡金属催化剂及其制备方法和应用
CN116099390B (zh) * 2022-11-14 2024-07-23 石河子大学 一种混合维度材料PNT@NiCo-LDH及其制备方法与应用
WO2024211696A1 (en) * 2023-04-07 2024-10-10 Biogen Ma Inc. 1h-pyrrolo[2,3-b]pyridin-4-yl]-2-oxopyrrolidine-3-carbonitrile derivatives as tyrosine kinase 2 (tyk2) inhibitors for the treatment of inflammatory diseases
TW202508595A (zh) 2023-05-04 2025-03-01 美商銳新醫藥公司 用於ｒａｓ相關疾病或病症之組合療法
US20250049810A1 (en) 2023-08-07 2025-02-13 Revolution Medicines, Inc. Methods of treating a ras protein-related disease or disorder
CN121969626A (zh) * 2023-09-27 2026-05-01 苏州必扬医药科技有限公司 一种Menin-MLL相互作用抑制剂及其制备方法和应用
AU2024360465A1 (en) 2023-10-12 2026-04-09 Revolution Medicines, Inc. Macrocyclic ras inhibitors
WO2025171296A1 (en) 2024-02-09 2025-08-14 Revolution Medicines, Inc. Ras inhibitors
WO2025181153A1 (en) * 2024-03-01 2025-09-04 F. Hoffmann-La Roche Ag Use of atr inhibitors in combination with pi3k alpha inhibitors
WO2025217307A1 (en) 2024-04-09 2025-10-16 Revolution Medicines, Inc. Methods for predicting response to a ras(on) inhibitor and combination therapies
TW202545519A (zh) * 2024-05-15 2025-12-01 俄羅斯聯邦商拜奧卡德聯合股份公司 共濟失調毛細血管擴張症和Ｒａｄ３相關激酶抑制劑
TW202547461A (zh) 2024-05-17 2025-12-16 美商銳新醫藥公司 Ｒａｓ抑制劑
WO2025255438A1 (en) 2024-06-07 2025-12-11 Revolution Medicines, Inc. Methods of treating a ras protein-related disease or disorder
WO2025265060A1 (en) 2024-06-21 2025-12-26 Revolution Medicines, Inc. Therapeutic compositions and methods for managing treatment-related effects
WO2026006747A1 (en) 2024-06-28 2026-01-02 Revolution Medicines, Inc. Ras inhibitors
WO2026015796A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Methods of treating a ras related disease or disorder
WO2026015825A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Use of ras inhibitor for treating pancreatic cancer
WO2026015801A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Methods of treating a ras related disease or disorder
WO2026015790A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Methods of treating a ras related disease or disorder
WO2026050446A1 (en) 2024-08-29 2026-03-05 Revolution Medicines, Inc. Ras inhibitors
WO2026072904A2 (en) 2024-09-26 2026-04-02 Revolution Medicines, Inc. Compositions and methods for treating lung cancer

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA030141B1 (ru) * 2009-12-31 2018-06-29 Хатчисон Медифарма Лимитед Определенные триазолопиридины и триазолопиразины, их композиции и способы их применения
WO2012005805A1 (en) * 2010-05-07 2012-01-12 Glaxosmithkline Llc Azaindazoles
WO2012118812A2 (en) * 2011-02-28 2012-09-07 Epizyme, Inc. Substituted 6,5-fused bicyclic heteroaryl compounds
EP2755962B1 (en) * 2011-09-13 2017-03-01 Glaxosmithkline LLC Azaindazoles
WO2013067302A1 (en) * 2011-11-04 2013-05-10 Glaxosmithkline Intellectual Property (No. 2) Limited Method of treatment
US8906910B2 (en) 2011-12-20 2014-12-09 Glaxosmithkline Llc Imidazopyridine derivatives as PI3 kinase
TWI656121B (zh) 2014-08-04 2019-04-11 德商拜耳製藥公司 ２－（嗎啉－４－基）－１，７－萘啶
ES2865330T3 (es) * 2015-04-29 2021-10-15 Janssen Pharmaceutica Nv Azabenzimidazoles y su uso como moduladores del receptor AMPA
CA3011189C (en) 2016-01-14 2024-02-20 Bayer Pharma Aktiengesellschaft 5-substituted 2-(morpholin-4-yl)-1,7-naphthyridines
AU2019373416A1 (en) * 2018-10-30 2021-06-10 Repare Therapeutics Inc. Compounds, pharmaceutical compositions, and methods of preparing compounds and of their use as ATR kinase inhibitors
KR20220035925A (ko) 2019-07-22 2022-03-22 리페어 세라퓨틱스 인크. Atr 키나제 억제제로서의 치환된 2-모르폴리노피리딘 유도체

Also Published As

Publication number Publication date
WO2021012049A1 (en) 2021-01-28
CN114174292B (zh) 2024-06-18
EP4003993A1 (en) 2022-06-01
JP7758895B2 (ja) 2025-10-22
BR112022000431A2 (pt) 2022-03-03
CO2022001853A2 (es) 2022-03-29
UA129807C2 (uk) 2025-08-06
CR20220068A (es) 2022-06-30
JP2022541825A (ja) 2022-09-27
IL289763A (en) 2022-03-01
PH12022550156A1 (en) 2023-05-08
KR20220035925A (ko) 2022-03-22
WO2021012049A8 (en) 2021-04-15
MX2022000854A (es) 2022-02-10
US20220185809A1 (en) 2022-06-16
AU2020317381A1 (en) 2022-02-10
EP4003993A4 (en) 2023-01-18
ECSP22012347A (es) 2022-03-31
CN114174292A (zh) 2022-03-11
JP2025061048A (ja) 2025-04-10
JP7617076B2 (ja) 2025-01-17

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