CA3139827A1 - Use of bispecific antigen-binding molecules that bind psma and cd3 in combination with 4-1bb co-stimulation - Google Patents

Use of bispecific antigen-binding molecules that bind psma and cd3 in combination with 4-1bb co-stimulation Download PDF

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Publication number
CA3139827A1
CA3139827A1 CA3139827A CA3139827A CA3139827A1 CA 3139827 A1 CA3139827 A1 CA 3139827A1 CA 3139827 A CA3139827 A CA 3139827A CA 3139827 A CA3139827 A CA 3139827A CA 3139827 A1 CA3139827 A1 CA 3139827A1
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Canada
Prior art keywords
psma
antigen
binding
antibody
tumor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3139827A
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English (en)
French (fr)
Inventor
Jessica R. Kirshner
Alison CRAWFORD
Danica CHIU
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Regeneron Pharmaceuticals Inc
Original Assignee
Chiu Danica
Regeneron Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiu Danica, Regeneron Pharmaceuticals Inc filed Critical Chiu Danica
Publication of CA3139827A1 publication Critical patent/CA3139827A1/en
Pending legal-status Critical Current

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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3069—Reproductive system, e.g. ovaria, uterus, testes, prostate
    • C—CHEMISTRY; METALLURGY
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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  • Health & Medical Sciences (AREA)
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  • Chemical & Material Sciences (AREA)
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  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
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  • Reproductive Health (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
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  • General Chemical & Material Sciences (AREA)
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  • Microbiology (AREA)
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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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CA3139827A 2019-06-21 2020-06-19 Use of bispecific antigen-binding molecules that bind psma and cd3 in combination with 4-1bb co-stimulation Pending CA3139827A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962864999P 2019-06-21 2019-06-21
US62/864,999 2019-06-21
PCT/US2020/038786 WO2020257681A1 (en) 2019-06-21 2020-06-19 Use of bispecific antigen-binding molecules that bind psma and cd3 in combination with 4-1bb co-stimulation

Publications (1)

Publication Number Publication Date
CA3139827A1 true CA3139827A1 (en) 2020-12-24

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CA3139827A Pending CA3139827A1 (en) 2019-06-21 2020-06-19 Use of bispecific antigen-binding molecules that bind psma and cd3 in combination with 4-1bb co-stimulation

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Country Link
US (1) US20200399372A1 (https=)
EP (1) EP3986933A1 (https=)
JP (2) JP7743313B2 (https=)
KR (1) KR20220024594A (https=)
CN (2) CN118526580A (https=)
AU (1) AU2020296181A1 (https=)
CA (1) CA3139827A1 (https=)
IL (1) IL289041A (https=)
MA (1) MA56515A (https=)
MX (1) MX2021015271A (https=)
WO (1) WO2020257681A1 (https=)
ZA (1) ZA202109048B (https=)

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Publication number Priority date Publication date Assignee Title
WO2023147784A1 (zh) * 2022-02-07 2023-08-10 江苏恒瑞医药股份有限公司 特异性结合psma和cd3的抗原结合分子及其医药用途
KR20250010677A (ko) * 2022-05-16 2025-01-21 리제너론 파아마슈티컬스, 인크. 이중특이적 항-PSMA x 항-CD3 항체를 단독으로 또는 항-PD-1 항체와 병용으로 전이성 거세 저항성 전립선암을 치료하는 방법
WO2025070636A1 (ja) * 2023-09-26 2025-04-03 ブライトパス・バイオ株式会社 Ｃｄ３９を標的とする多重特異性抗原結合性分子
CN118086511B (zh) * 2024-04-25 2024-07-09 中国中医科学院望京医院(中国中医科学院骨伤科研究所) 胃粘膜肠上皮化生亚型生物标志物folh1及其应用

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IL289041A (en) 2022-02-01
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WO2020257681A1 (en) 2020-12-24
EP3986933A1 (en) 2022-04-27
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