CA3139535A1 - Methods and systems for detecting residual disease - Google Patents
Methods and systems for detecting residual disease Download PDFInfo
- Publication number
- CA3139535A1 CA3139535A1 CA3139535A CA3139535A CA3139535A1 CA 3139535 A1 CA3139535 A1 CA 3139535A1 CA 3139535 A CA3139535 A CA 3139535A CA 3139535 A CA3139535 A CA 3139535A CA 3139535 A1 CA3139535 A1 CA 3139535A1
- Authority
- CA
- Canada
- Prior art keywords
- methods
- systems
- disease
- individual
- nucleic acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 201000010099 disease Diseases 0.000 title abstract 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 4
- 206010028980 Neoplasm Diseases 0.000 abstract 2
- 201000011510 cancer Diseases 0.000 abstract 2
- 150000007523 nucleic acids Chemical class 0.000 abstract 2
- 102000039446 nucleic acids Human genes 0.000 abstract 2
- 108020004707 nucleic acids Proteins 0.000 abstract 2
- 238000012163 sequencing technique Methods 0.000 abstract 2
- 239000002773 nucleotide Substances 0.000 abstract 1
- 125000003729 nucleotide group Chemical group 0.000 abstract 1
- 238000005070 sampling Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6869—Methods for sequencing
-
- G—PHYSICS
- G06—COMPUTING; CALCULATING OR COUNTING
- G06F—ELECTRIC DIGITAL DATA PROCESSING
- G06F17/00—Digital computing or data processing equipment or methods, specially adapted for specific functions
- G06F17/10—Complex mathematical operations
- G06F17/18—Complex mathematical operations for evaluating statistical data, e.g. average values, frequency distributions, probability functions, regression analysis
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
- G16B20/20—Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2537/00—Reactions characterised by the reaction format or use of a specific feature
- C12Q2537/10—Reactions characterised by the reaction format or use of a specific feature the purpose or use of
- C12Q2537/165—Mathematical modelling, e.g. logarithm, ratio
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Theoretical Computer Science (AREA)
- General Physics & Mathematics (AREA)
- Data Mining & Analysis (AREA)
- Pathology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Evolutionary Biology (AREA)
- Mathematical Optimization (AREA)
- Pure & Applied Mathematics (AREA)
- Computational Mathematics (AREA)
- Mathematical Analysis (AREA)
- Mathematical Physics (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Medical Informatics (AREA)
- Operations Research (AREA)
- Algebra (AREA)
- Probability & Statistics with Applications (AREA)
- Databases & Information Systems (AREA)
- Software Systems (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962849414P | 2019-05-17 | 2019-05-17 | |
| US62/849,414 | 2019-05-17 | ||
| US202062971530P | 2020-02-07 | 2020-02-07 | |
| US62/971,530 | 2020-02-07 | ||
| PCT/US2020/033217 WO2020236630A1 (en) | 2019-05-17 | 2020-05-15 | Methods and systems for detecting residual disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3139535A1 true CA3139535A1 (en) | 2020-11-26 |
Family
ID=73458794
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3139535A Pending CA3139535A1 (en) | 2019-05-17 | 2020-05-15 | Methods and systems for detecting residual disease |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20200392584A1 (ja) |
| EP (1) | EP3969617A4 (ja) |
| JP (1) | JP2022532403A (ja) |
| KR (1) | KR20220032525A (ja) |
| CN (1) | CN114127308A (ja) |
| AU (1) | AU2020279107A1 (ja) |
| CA (1) | CA3139535A1 (ja) |
| IL (1) | IL288098A (ja) |
| WO (1) | WO2020236630A1 (ja) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20220032516A (ko) | 2019-05-03 | 2022-03-15 | 울티마 제노믹스, 인크. | 합성 방법에 의한 고속-정방향 시퀀싱 |
| EP3963105A4 (en) | 2019-05-03 | 2023-12-20 | Ultima Genomics, Inc. | METHOD FOR DETECTING NUCLEIC ACID VARIANTS |
| AU2020309582B2 (en) | 2019-07-10 | 2022-02-24 | Ultima Genomics, Inc. | RNA sequencing methods |
| WO2024091545A1 (en) * | 2022-10-25 | 2024-05-02 | Cornell University | Nucleic acid error suppression |
| CN116356001B (zh) * | 2023-02-07 | 2023-12-15 | 江苏先声医学诊断有限公司 | 一种基于血液循环肿瘤dna的双重背景噪声突变去除方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20050019787A1 (en) * | 2003-04-03 | 2005-01-27 | Perlegen Sciences, Inc., A Delaware Corporation | Apparatus and methods for analyzing and characterizing nucleic acid sequences |
| US8772473B2 (en) * | 2009-03-30 | 2014-07-08 | The Regents Of The University Of California | Mostly natural DNA sequencing by synthesis |
| WO2013188605A2 (en) * | 2012-06-15 | 2013-12-19 | Nuclea Biotechnologies, Inc. | Predictive markers for cancer and metabolic syndrome |
| US11261494B2 (en) * | 2012-06-21 | 2022-03-01 | The Chinese University Of Hong Kong | Method of measuring a fractional concentration of tumor DNA |
| CN113337604A (zh) * | 2013-03-15 | 2021-09-03 | 莱兰斯坦福初级大学评议会 | 循环核酸肿瘤标志物的鉴别和用途 |
| AU2017225876B2 (en) * | 2016-02-29 | 2021-03-04 | Foundation Medicine, Inc. | Methods and systems for evaluating tumor mutational burden |
| WO2017181146A1 (en) * | 2016-04-14 | 2017-10-19 | Guardant Health, Inc. | Methods for early detection of cancer |
| CN111164701A (zh) * | 2017-10-06 | 2020-05-15 | 格瑞尔公司 | 针对靶标定序的定点噪声模型 |
| EP3776555A2 (en) * | 2018-04-13 | 2021-02-17 | Grail, Inc. | Multi-assay prediction model for cancer detection |
-
2020
- 2020-05-15 KR KR1020217041274A patent/KR20220032525A/ko unknown
- 2020-05-15 CN CN202080051437.1A patent/CN114127308A/zh active Pending
- 2020-05-15 CA CA3139535A patent/CA3139535A1/en active Pending
- 2020-05-15 US US16/875,645 patent/US20200392584A1/en active Pending
- 2020-05-15 AU AU2020279107A patent/AU2020279107A1/en active Pending
- 2020-05-15 EP EP20810314.3A patent/EP3969617A4/en active Pending
- 2020-05-15 WO PCT/US2020/033217 patent/WO2020236630A1/en unknown
- 2020-05-15 JP JP2021568310A patent/JP2022532403A/ja active Pending
-
2021
- 2021-11-14 IL IL288098A patent/IL288098A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| KR20220032525A (ko) | 2022-03-15 |
| WO2020236630A1 (en) | 2020-11-26 |
| IL288098A (en) | 2022-01-01 |
| JP2022532403A (ja) | 2022-07-14 |
| US20200392584A1 (en) | 2020-12-17 |
| EP3969617A4 (en) | 2023-08-16 |
| AU2020279107A1 (en) | 2021-11-25 |
| CN114127308A (zh) | 2022-03-01 |
| EP3969617A1 (en) | 2022-03-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20240515 |