CA3137519A1 - Compositions and methods for tcr reprogramming using fusion proteins - Google Patents

Compositions and methods for tcr reprogramming using fusion proteins Download PDF

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Publication number
CA3137519A1
CA3137519A1 CA3137519A CA3137519A CA3137519A1 CA 3137519 A1 CA3137519 A1 CA 3137519A1 CA 3137519 A CA3137519 A CA 3137519A CA 3137519 A CA3137519 A CA 3137519A CA 3137519 A1 CA3137519 A1 CA 3137519A1
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Prior art keywords
tcr
cell
nucleic acid
domain
acid molecule
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CA3137519A
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English (en)
French (fr)
Inventor
Philippe KIEFFER-KWON
Ella LIBERZON
Robert Hofmeister
Patrick Alexander BAEUERLE
Daniel Getts
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TCR2 Therapeutics Inc
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TCR2 Therapeutics Inc
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Publication of CA3137519A1 publication Critical patent/CA3137519A1/en
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
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    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
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    • C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
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    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
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    • C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
    • C12N2840/203—Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES

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CA3137519A 2019-04-22 2020-04-22 Compositions and methods for tcr reprogramming using fusion proteins Pending CA3137519A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962836977P 2019-04-22 2019-04-22
US62/836,977 2019-04-22
US201962943679P 2019-12-04 2019-12-04
US62/943,679 2019-12-04
PCT/US2020/029344 WO2020219563A1 (en) 2019-04-22 2020-04-22 Compositions and methods for tcr reprogramming using fusion proteins

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CA3137519A1 true CA3137519A1 (en) 2020-10-29

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CA3137519A Pending CA3137519A1 (en) 2019-04-22 2020-04-22 Compositions and methods for tcr reprogramming using fusion proteins

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US (1) US20220362295A1 (https=)
EP (1) EP3959322A4 (https=)
JP (1) JP2022530037A (https=)
CN (1) CN114258430A (https=)
AU (1) AU2020262111A1 (https=)
CA (1) CA3137519A1 (https=)
WO (1) WO2020219563A1 (https=)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL3298033T5 (pl) 2015-05-18 2023-10-30 TCR2 Therapeutics Inc. Kompozycje i zastosowania medyczne do reprogramowania TCR z zastosowaniem białek fuzyjnych
WO2017222911A1 (en) 2016-06-20 2017-12-28 The Board Of Trustees Of The Leland Stanford Junior University Circular rnas and their use in immunomodulation
US20220288176A1 (en) * 2019-08-28 2022-09-15 The Board Of Trustees Of The Leland Stanford Junior University Circular rna modification and methods of use
KR20230028375A (ko) 2020-06-25 2023-02-28 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 원형 rna 번역을 구동하는 유전 요소와 이를 사용하는 방법
GB202011993D0 (en) 2020-07-31 2020-09-16 Adc Therapeutics Sa ANTI-IL 13Ra2 antibodies
EP3964585A1 (en) * 2020-09-03 2022-03-09 Miltenyi Biotec B.V. & Co. KG Cd62l specific lentiviral vector particle for targeted transduction of t cell subsets
CA3197316A1 (en) * 2020-09-29 2022-04-07 NeuExcell Therapeutics Inc. Neurod1 and dlx2 vector
CN114516913B (zh) * 2020-11-19 2023-04-28 东莞市朋志生物科技有限公司 抗n末端脑钠肽前体的抗体和检测试剂盒
WO2022116528A1 (zh) * 2020-12-04 2022-06-09 苏州科锐迈德生物医药科技有限公司 环状rna、包含环状rna的疫苗及用于检测新型冠状病毒中和抗体的试剂盒
CN112481289B (zh) 2020-12-04 2023-06-27 苏州科锐迈德生物医药科技有限公司 一种转录环状rna的重组核酸分子及其在蛋白表达中的应用
JPWO2023027082A1 (https=) * 2021-08-23 2023-03-02
WO2023070043A1 (en) * 2021-10-20 2023-04-27 Yale University Compositions and methods for targeted editing and evolution of repetitive genetic elements
JP2025504398A (ja) * 2022-01-10 2025-02-12 リジェネロン・ファーマシューティカルズ・インコーポレイテッド Ｍｕｃ１６キメラ抗原受容体
CN114606263B (zh) * 2022-05-11 2022-09-06 上海优替济生生物医药有限公司 分离的核酸分子及其用途
JP2025530303A (ja) * 2022-09-10 2025-09-11 エクスクルサーク・（スージョウ）・バイオメディカル・カンパニー・リミテッド 環状ｒｎａ及びその調製方法
CN116411023B (zh) * 2023-02-24 2025-08-12 北京大学人民医院 一种新型环状rna成环序列构建car-t细胞及在治疗小细胞肺癌中的应用
WO2024215872A1 (en) * 2023-04-11 2024-10-17 The Regents Of The University Of California Human t cell receptors targeting tumor-enhanced splicing epitopes on hla-a*02:01 for small cell carcinoma
WO2024236366A2 (en) * 2023-05-12 2024-11-21 Sekkei Bio Private Limited Design and method of generating scarless circular rna

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015034925A1 (en) * 2013-09-03 2015-03-12 Moderna Therapeutics, Inc. Circular polynucleotides
PL3298033T5 (pl) * 2015-05-18 2023-10-30 TCR2 Therapeutics Inc. Kompozycje i zastosowania medyczne do reprogramowania TCR z zastosowaniem białek fuzyjnych
ES2891578T3 (es) * 2016-04-01 2022-01-28 Kite Pharma Inc Antígeno quimérico y receptores de células T y métodos de uso
WO2018067993A1 (en) * 2016-10-07 2018-04-12 TCR2 Therapeutics Inc. Compositions and methods for t-cell receptors reprogramming using fusion proteins
WO2018232020A1 (en) * 2017-06-13 2018-12-20 TCR2 Therapeutics Inc. Compositions and methods for tcr reprogramming using fusion proteins
WO2019222275A2 (en) * 2018-05-14 2019-11-21 TCR2 Therapeutics Inc. Compositions and methods for tcr reprogramming using inducible fusion proteins

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