CN114258430A - 使用融合蛋白进行tcr重编程的组合物和方法 - Google Patents

使用融合蛋白进行tcr重编程的组合物和方法 Download PDF

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CN114258430A
CN114258430A CN202080045885.0A CN202080045885A CN114258430A CN 114258430 A CN114258430 A CN 114258430A CN 202080045885 A CN202080045885 A CN 202080045885A CN 114258430 A CN114258430 A CN 114258430A
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tcr
cells
domain
nucleic acid
cell
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菲利普·基弗-权
埃拉·利伯索恩
罗伯特·霍夫梅斯特
帕特里克·亚历山大·博伊尔勒
丹尼尔·盖茨
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TCR2 Therapeutics Inc
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TCR2 Therapeutics Inc
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CN202080045885.0A 2019-04-22 2020-04-22 使用融合蛋白进行tcr重编程的组合物和方法 Pending CN114258430A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962836977P 2019-04-22 2019-04-22
US62/836,977 2019-04-22
US201962943679P 2019-12-04 2019-12-04
US62/943,679 2019-12-04
PCT/US2020/029344 WO2020219563A1 (en) 2019-04-22 2020-04-22 Compositions and methods for tcr reprogramming using fusion proteins

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US (1) US20220362295A1 (https=)
EP (1) EP3959322A4 (https=)
JP (1) JP2022530037A (https=)
CN (1) CN114258430A (https=)
AU (1) AU2020262111A1 (https=)
CA (1) CA3137519A1 (https=)
WO (1) WO2020219563A1 (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
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CN114606263A (zh) * 2022-05-11 2022-06-10 上海优替济生生物医药有限公司 分离的核酸分子及其用途
CN116411023A (zh) * 2023-02-24 2023-07-11 北京大学人民医院 一种新型环状rna成环序列构建car-t细胞及在治疗小细胞肺癌中的应用

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PL3298033T5 (pl) 2015-05-18 2023-10-30 TCR2 Therapeutics Inc. Kompozycje i zastosowania medyczne do reprogramowania TCR z zastosowaniem białek fuzyjnych
WO2017222911A1 (en) 2016-06-20 2017-12-28 The Board Of Trustees Of The Leland Stanford Junior University Circular rnas and their use in immunomodulation
US20220288176A1 (en) * 2019-08-28 2022-09-15 The Board Of Trustees Of The Leland Stanford Junior University Circular rna modification and methods of use
KR20230028375A (ko) 2020-06-25 2023-02-28 더 보드 어브 트러스티스 어브 더 리랜드 스탠포드 주니어 유니버시티 원형 rna 번역을 구동하는 유전 요소와 이를 사용하는 방법
GB202011993D0 (en) 2020-07-31 2020-09-16 Adc Therapeutics Sa ANTI-IL 13Ra2 antibodies
EP3964585A1 (en) * 2020-09-03 2022-03-09 Miltenyi Biotec B.V. & Co. KG Cd62l specific lentiviral vector particle for targeted transduction of t cell subsets
CA3197316A1 (en) * 2020-09-29 2022-04-07 NeuExcell Therapeutics Inc. Neurod1 and dlx2 vector
CN114516913B (zh) * 2020-11-19 2023-04-28 东莞市朋志生物科技有限公司 抗n末端脑钠肽前体的抗体和检测试剂盒
WO2022116528A1 (zh) * 2020-12-04 2022-06-09 苏州科锐迈德生物医药科技有限公司 环状rna、包含环状rna的疫苗及用于检测新型冠状病毒中和抗体的试剂盒
CN112481289B (zh) 2020-12-04 2023-06-27 苏州科锐迈德生物医药科技有限公司 一种转录环状rna的重组核酸分子及其在蛋白表达中的应用
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WO2023070043A1 (en) * 2021-10-20 2023-04-27 Yale University Compositions and methods for targeted editing and evolution of repetitive genetic elements
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