CA3134689A1 - Conditioning methods for gene therapy - Google Patents

Conditioning methods for gene therapy Download PDF

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Publication number
CA3134689A1
CA3134689A1 CA3134689A CA3134689A CA3134689A1 CA 3134689 A1 CA3134689 A1 CA 3134689A1 CA 3134689 A CA3134689 A CA 3134689A CA 3134689 A CA3134689 A CA 3134689A CA 3134689 A1 CA3134689 A1 CA 3134689A1
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Canada
Prior art keywords
seq
set forth
amino acid
acid sequence
antibody
Prior art date
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Pending
Application number
CA3134689A
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English (en)
French (fr)
Inventor
Anthony Boitano
Michael Cooke
Rahul Palchaudhuri
Bradley R. PEARSE
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Dianthus Therapeutics Inc
Original Assignee
Magenta Therapeutics Inc
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Application filed by Magenta Therapeutics Inc filed Critical Magenta Therapeutics Inc
Publication of CA3134689A1 publication Critical patent/CA3134689A1/en
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
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    • A61K47/6825—Ribosomal inhibitory proteins, i.e. RIP-I or RIP-II, e.g. Pap, gelonin or dianthin
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CA3134689A 2019-04-24 2020-04-24 Conditioning methods for gene therapy Pending CA3134689A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962838278P 2019-04-24 2019-04-24
US62/838,278 2019-04-24
US201962944925P 2019-12-06 2019-12-06
US62/944,925 2019-12-06
PCT/US2020/029934 WO2020219964A1 (en) 2019-04-24 2020-04-24 Conditioning methods for gene therapy

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CA3134689A1 true CA3134689A1 (en) 2020-10-29

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CA3134689A Pending CA3134689A1 (en) 2019-04-24 2020-04-24 Conditioning methods for gene therapy

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