CA3127854A1 - Methods and compositions comprising a 5ht receptor agonist for the treatment of psychological, cognitive, behavioral, and/or mood disorders - Google Patents

Methods and compositions comprising a 5ht receptor agonist for the treatment of psychological, cognitive, behavioral, and/or mood disorders Download PDF

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Publication number
CA3127854A1
CA3127854A1 CA3127854A CA3127854A CA3127854A1 CA 3127854 A1 CA3127854 A1 CA 3127854A1 CA 3127854 A CA3127854 A CA 3127854A CA 3127854 A CA3127854 A CA 3127854A CA 3127854 A1 CA3127854 A1 CA 3127854A1
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Canada
Prior art keywords
receptor agonist
pharmaceutically acceptable
prodrug
less
metabolite
Prior art date
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Pending
Application number
CA3127854A
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English (en)
French (fr)
Inventor
Judith BLUMSTOCK
William J. Tyler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Diamond Therapeutics Inc
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Diamond Therapeutics Inc
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Publication date
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Publication of CA3127854A1 publication Critical patent/CA3127854A1/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings
    • C07F9/5728—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
    • A—HUMAN NECESSITIES
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    • A61K31/12—Ketones
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    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
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    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
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    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
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    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
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    • A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
    • A—HUMAN NECESSITIES
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    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
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  • Health & Medical Sciences (AREA)
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  • Pharmacology & Pharmacy (AREA)
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  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • Organic Chemistry (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Psychiatry (AREA)
  • Molecular Biology (AREA)
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  • Optics & Photonics (AREA)
  • Nanotechnology (AREA)
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  • Alternative & Traditional Medicine (AREA)
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  • Biophysics (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA3127854A 2019-01-30 2020-01-29 Methods and compositions comprising a 5ht receptor agonist for the treatment of psychological, cognitive, behavioral, and/or mood disorders Pending CA3127854A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962799010P 2019-01-30 2019-01-30
US201962798998P 2019-01-30 2019-01-30
US62/799,010 2019-01-30
US62/798,998 2019-01-30
PCT/IB2020/000052 WO2020157569A1 (en) 2019-01-30 2020-01-29 Methods and compositions comprising a 5ht receptor agonist for the treatment of psychological, cognitive, behavioral, and/or mood disorders

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CA3127854A1 true CA3127854A1 (en) 2020-08-06

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US (4) US20220096504A1 (enExample)
EP (1) EP3917537A4 (enExample)
JP (2) JP2022523700A (enExample)
KR (1) KR20210134313A (enExample)
CN (1) CN114040767A (enExample)
AU (2) AU2020215150B8 (enExample)
BR (1) BR112021014750A2 (enExample)
CA (1) CA3127854A1 (enExample)
IL (1) IL285186A (enExample)
MA (1) MA54877A (enExample)
MX (2) MX2021009037A (enExample)
WO (1) WO2020157569A1 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022079574A1 (en) * 2020-10-12 2022-04-21 Goodcap Pharmaceuticals Ltd. Compositions for reducing inflammation to improve or maintain mental or physical health
WO2022221942A1 (en) * 2021-04-19 2022-10-27 Betterlife Pharma Inc. Prevention of drug diversion
US11724985B2 (en) 2020-05-19 2023-08-15 Cybin Irl Limited Deuterated tryptamine derivatives and methods of use

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL304040B2 (en) 2016-07-07 2024-09-01 Hughes Howard Med Inst Modified ligand-gated ion channels and methods of use
US12459965B2 (en) 2017-10-09 2025-11-04 Compass Pathfinder Limited Preparation of psilocybin, different polymorphic forms, intermediates, formulations and their use
GB2571696B (en) 2017-10-09 2020-05-27 Compass Pathways Ltd Large scale method for the preparation of Psilocybin and formulations of Psilocybin so produced
SG11202004246YA (en) 2017-11-10 2020-06-29 Hughes Howard Med Inst Modified ligand-gated ion channels and methods of use
CA3132731A1 (en) * 2019-03-07 2020-09-10 University Of Padova Compositions and methods of use comprising substances with neural plasticity actions administered at non-psychedelic/psychotomimetic dosages and formulations
US12377112B2 (en) 2019-04-17 2025-08-05 Compass Pathfinder Limited Methods of treating neurocognitive disorders, chronic pain and reducing inflammation
EP4003395A4 (en) * 2019-07-23 2023-07-19 Caamtech, Inc. COMPOSITIONS WITH TOAD SECRETION COMPOUNDS
CA3152752A1 (en) 2019-10-01 2021-04-08 Thomas Henley Genetic engineering of fungi to modulate tryptamine expression
AU2020358869A1 (en) 2019-10-03 2022-04-14 Pike Therapeutics Usa, Inc. Transdermal delivery of dronabinol
US12409131B2 (en) 2019-10-03 2025-09-09 Pike Therapeutics Usa, Inc. Transdermal delivery of dronabinol
EP4041209A4 (en) 2019-10-11 2024-01-24 Pike Therapeutics, Inc. TRANSDERMAL COMPOSITIONS COMPRISING CANNABIDIOL (CBD) FOR USE IN THE TREATMENT OF EPILEPTIC DISORDERS
US12016829B2 (en) 2019-10-11 2024-06-25 Pike Therapeutics Inc. Pharmaceutical composition and method for treating seizure disorders
CA3155181A1 (en) 2019-10-14 2021-04-22 Pike Therapeutics, Inc., 1219014 B.C. Ltd. Transdermal delivery of cannabidiol
US12121617B2 (en) 2019-10-14 2024-10-22 Pike Therapeutics Inc. Transdermal delivery of cannabidiol
US12268699B2 (en) 2019-10-14 2025-04-08 Pike Therapeutics Inc. Transdermal delivery of tetrahydrocannabinol
WO2021072530A1 (en) * 2019-10-15 2021-04-22 Tassili Life Sciences, Corp. Controlled release formulations of psilocybe-derived agents and method for their use, and methods and compositions for threating mild traumatic brain injury with post traumatic stress disorder.
CA3160793A1 (en) * 2019-12-04 2021-06-10 Neonmind Biosciences Inc. Use of psilocin, psilocybin or analogs thereof in weight loss, treatment of obesity and compulsive eating disorder
US20210220336A1 (en) * 2020-01-22 2021-07-22 Clexio Biosciences Ltd. Topical detomidine formulations
KR20220137081A (ko) 2020-02-04 2022-10-11 마인드셋 파마 인크. Cns 장애의 치료를 위한 세로토닌성 사이키델릭 작용제로서의 실로신 유도체
BR112022015379A2 (pt) 2020-02-04 2022-09-27 Mindset Pharma Inc Derivados de 3-pirrolidino-indol como agentes psicodélicos serotonérgicos para o tratamento de distúrbios do snc
EP4135713A4 (en) * 2020-04-17 2024-04-17 Revive Therapeutics Ltd. Use of psilocybin in the treatment of neurological brain injury and migraines
WO2021225796A1 (en) 2020-05-05 2021-11-11 Universitätsspital Basel Mdma treatment to enhance acute emotional effects profile of lsd, psilocybin or other psychedelics
WO2021226416A1 (en) 2020-05-08 2021-11-11 Psilera Inc. Novel compositions of matter and pharmaceutical compositions
WO2021243460A1 (en) * 2020-06-03 2021-12-09 Neonmind Biosciences Inc. Method for weight loss with therapy
WO2022023812A1 (en) * 2020-07-29 2022-02-03 Diamond Therapeutics Inc. Extended release 5-ht receptor agonists for neurological conditions
US20220062310A1 (en) * 2020-09-03 2022-03-03 Yale University Psilocybin in patients with obsessive-compulsive disorder
WO2022072808A1 (en) * 2020-10-01 2022-04-07 Mydecine Innovations Group Inc. Novel psychedelic compositions, delivery systems and therapeutic uses thereof
US12029718B2 (en) 2021-11-09 2024-07-09 Cct Sciences, Llc Process for production of essentially pure delta-9-tetrahydrocannabinol
US20230398234A1 (en) * 2020-10-28 2023-12-14 Mydecine Innovations Group Inc. Novel fungal compoind formulations and their therapeutic methods of use
WO2022115798A2 (en) * 2020-11-30 2022-06-02 Wesana Health Inc. Compositions and methods for treating migraine
WO2022115796A1 (en) * 2020-11-30 2022-06-02 Wesana Health Inc. Compositions and methods for treating neurological conditions
KR20230109765A (ko) 2020-12-09 2023-07-20 캄테크, 인크. 다이알킬 트립타민 및 이의 치료적 용도
CA3113240C (en) 2020-12-28 2023-09-05 Psilo Scientific Ltd. Transmucosal psychoactive alkaloid composition and preparation thereof
US12534441B2 (en) 2021-01-15 2026-01-27 Beckley Psytech Limited Tryptamine analogues
EP4155306A1 (en) 2021-01-15 2023-03-29 Beckley Psytech Limited Neuroactive ergoline analogue
US20220265601A1 (en) * 2021-02-10 2022-08-25 David Alan Heldreth, JR. Methods of use and formulations of allosteric modulators of the serotonin, dopamine and other receptor systems for medical, recreational, religious, research and other uses.
US11312684B1 (en) 2021-02-10 2022-04-26 Eleusis Therapeutics Us, Inc. Pharmaceutically acceptable salts of psilocin and uses thereof
US20220273628A1 (en) * 2021-02-19 2022-09-01 Universitätsspital Basel Effects of lysergic acid diethylamide (lsd) and of lsd analogs to assist psychotherapy for generalized anxiety disorder or other anxiety not related to life-threatening illness
US20220370413A1 (en) * 2021-03-06 2022-11-24 Mind Medicine, Inc. Formulations of psilocin that have enhanced stability
EP4304603A4 (en) * 2021-03-08 2025-01-22 Diamond Therapeutics Inc. 5-ht receptor agonist titration
WO2022204323A1 (en) * 2021-03-24 2022-09-29 The Trustees Of Columbia University In The City Of New York Non-hallucinogenic ariadne analogs for treatment of neurological and psychiatric disorders
TW202304466A (zh) * 2021-03-30 2023-02-01 英商康派斯開拓者公司 賽洛西賓（ｐｓｉｌｏｃｙｂｉｎ）組成物，其製備方法及使用方法
CA3215871A1 (en) * 2021-03-31 2022-10-06 Lyfe Chng, Llc Transdermal system, formulation, and method for the therapeutic administration of a psychedelic agent
US20220331292A1 (en) * 2021-04-16 2022-10-20 Callitas Health Inc. Compositions and methods for delivery of psilocin and prodrugs thereof
EP4329759A4 (en) 2021-04-30 2025-07-16 Mind Medicine Inc CRYSTALLINE FORMS OF LSD SALTS
JP2024517194A (ja) * 2021-05-03 2024-04-19 マインド メディシン， インコーポレイテッド サイケデリック薬の用量を漸増する方法
WO2022235514A1 (en) * 2021-05-04 2022-11-10 Mind Medicine, Inc. Liposome delivery of psychedelics
WO2022261058A1 (en) * 2021-06-07 2022-12-15 University Of Mississippi Methods for the pulsed delivery of bioactive agents
US11801256B2 (en) 2021-06-08 2023-10-31 Universitätsspital Basel Antidepressant-psilocybin co-treatment to assist psychotherapy
GB202109023D0 (en) * 2021-06-23 2021-08-04 Ldn Pharma Ltd Compositions comprising an agonist of 5-hydroxytryptamine (5-ht) receptor subtype 3
WO2022272176A1 (en) * 2021-06-25 2022-12-29 Synaptive Therapeutics, Llc Psilocybin analogs for treating psychological disorders
JP7846211B2 (ja) 2021-08-19 2026-04-14 デフィニウム セラピューティクス ユーエス， インコーポレイテッド 治療適用のためのｄ－リゼルグ酸ジエチルアミドの即時放出製剤
US12492178B2 (en) 2021-09-01 2025-12-09 Empathbio, Inc. Stable polymorph of R-MDMA HCl
EP4396162A4 (en) * 2021-09-03 2025-11-12 Alexander Shulgin Res Institute Inc ASYMMETRIC ALLYL TRYPTAMINES
US20230099972A1 (en) * 2021-09-30 2023-03-30 ATAI Life Sciences AG Compositions and methods for treating headaches
WO2023086962A1 (en) * 2021-11-12 2023-05-19 Terran Biosciences Inc. Psilocybin and o-acetylpsilocin, salts and solid state forms thereof
US20250011351A1 (en) 2021-11-12 2025-01-09 Terran Biosciences Inc. Psilocybin and o-acetylpsilocin, salts and solid state forms thereof
US11912680B2 (en) 2021-12-28 2024-02-27 Empathbio, Inc. Nitric oxide releasing prodrugs of MDA and MDMA
WO2023129956A2 (en) 2021-12-30 2023-07-06 ATAI Life Sciences AG Dimethyltryptamine analogues as nitric oxide delivery drugs
CN118984868A (zh) 2021-12-31 2024-11-19 恩派瑞安神经科学公司 用于产生精神药物生物碱的遗传修饰的生物体
EP4463153A4 (en) * 2022-01-12 2026-03-04 Eleusis Therapeutics Us Inc Psilocin benzoate formulation for intravenous infusion
WO2023168023A1 (en) 2022-03-04 2023-09-07 Reset Pharmaceuticals, Inc. Co-crystals or salts comprising psilocin
WO2023183618A1 (en) * 2022-03-25 2023-09-28 Ojai Energetics Pbc Psychedelic compositions and methods for forming the same
EP4514831A1 (en) * 2022-04-27 2025-03-05 Howard Hughes Medical Institute Chemogenetic receptors and methods of making and using
US20250114383A1 (en) * 2022-05-13 2025-04-10 Reset Pharmaceuticals, Inc. Administration of a psychedelic compound by intravenous infusion
IL315086A (en) 2022-06-09 2024-10-01 Diamond Therapeutics Inc Amorphous (A-polymorphic) psilocybin
WO2023248222A1 (en) * 2022-06-21 2023-12-28 Technion Research & Development Foundation Limited 5-ht2c receptor modulating agents for the treatment of neurodegenerative, mental, cognitive and autoimmune cns disorders
US20240000795A1 (en) * 2022-06-30 2024-01-04 Terran Biosciences Inc. Methods and compositions relating to controlling psychedelic effects with serotonin receptor modulators
WO2024015447A1 (en) * 2022-07-12 2024-01-18 Lobe Sciences Ltd. Preparation of stable psilocin salts, esters and conjugates and uses thereof
US12344583B2 (en) 2022-07-12 2025-07-01 Lobe Sciences Ltd. Solid psilocin salts
WO2024019908A1 (en) * 2022-07-19 2024-01-25 Lobe Sciences Ltd. Serotonergic psychedelic agent for treating selective mutism
US12264131B2 (en) 2022-08-19 2025-04-01 Beckley Psytech Limited Pharmaceutically acceptable salts and compositions thereof
WO2024079648A1 (en) * 2022-10-11 2024-04-18 Sintalica S.R.L. Delivery system for the controlled release of psychedelic compound, pharmaceutical composition and uses thereof
WO2024151625A1 (en) * 2023-01-10 2024-07-18 Georgetown University Non-toxic plga compositions and methods of making and using same
CN121358470A (zh) * 2023-02-23 2026-01-16 布莱特西德公司 用于调节g蛋白偶联受体的组合物和方法
US12246005B2 (en) 2023-06-13 2025-03-11 Beckley Psytech Limited 5-methoxy-n,n-dimethyltryptamine (5-MeO-DMT) formulations
WO2025010308A2 (en) * 2023-07-03 2025-01-09 Empathbio, Inc. Mdma enantiomer compositions and methods for modulating aggression response
WO2025024400A2 (en) * 2023-07-21 2025-01-30 2A Biosciences, Inc. Substituted tryptamines and uses thereof
WO2025040932A1 (en) * 2023-08-21 2025-02-27 Nechama Golan Fully curing all mental diseases with the use of d-lysergic acid amide in different doses and time of treatment
WO2026068690A1 (en) * 2024-09-27 2026-04-02 Medichem, S.A. Quetiapine long-acting injection

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4641942B2 (ja) * 2003-10-03 2011-03-02 フェーイレン・ナムローゼ・フェンノートシャップ ヒトおよび動物におけるｉｇｆ−１血清レベルの低下と関連した種々の疾患状態の治療用の治療用組成物の製造のための血清中ｉｇｆ−１レベルを増加できる化合物の使用
US20180021326A1 (en) * 2016-07-23 2018-01-25 Paul Edward Stamets Compositions and methods for enhancing neuroregeneration and cognition by combining mushroom extracts containing active ingredients psilocin or psilocybin with erinacines or hericenones enhanced with niacin
CN108619214A (zh) * 2017-03-15 2018-10-09 王慎君 一种治疗肿瘤的药物
GB2571696B (en) * 2017-10-09 2020-05-27 Compass Pathways Ltd Large scale method for the preparation of Psilocybin and formulations of Psilocybin so produced
CA3132731A1 (en) * 2019-03-07 2020-09-10 University Of Padova Compositions and methods of use comprising substances with neural plasticity actions administered at non-psychedelic/psychotomimetic dosages and formulations

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11724985B2 (en) 2020-05-19 2023-08-15 Cybin Irl Limited Deuterated tryptamine derivatives and methods of use
US11746088B2 (en) 2020-05-19 2023-09-05 Cybin Irl Limited Deuterated tryptamine derivatives and methods of use
US11834410B2 (en) 2020-05-19 2023-12-05 Cybin Irl Limited Deuterated tryptamine derivatives and methods of use
US11958807B2 (en) 2020-05-19 2024-04-16 Cybin Irl Limited Deuterated tryptamine derivatives and methods of use
US12110272B2 (en) 2020-05-19 2024-10-08 Cybin Irl Limited Deuterated tryptamine derivatives and methods of use
US12240813B2 (en) 2020-05-19 2025-03-04 Cybin Irl Limited Deuterated tryptamine derivatives and methods of use
US12291499B2 (en) 2020-05-19 2025-05-06 Cybin Irl Limited Deuterated tryptamine derivatives and methods of use
WO2022079574A1 (en) * 2020-10-12 2022-04-21 Goodcap Pharmaceuticals Ltd. Compositions for reducing inflammation to improve or maintain mental or physical health
WO2022221942A1 (en) * 2021-04-19 2022-10-27 Betterlife Pharma Inc. Prevention of drug diversion

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