CA3126406A1 - Analyte sensors and sensing methods for detecting creatinine - Google Patents

Analyte sensors and sensing methods for detecting creatinine Download PDF

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Publication number
CA3126406A1
CA3126406A1 CA3126406A CA3126406A CA3126406A1 CA 3126406 A1 CA3126406 A1 CA 3126406A1 CA 3126406 A CA3126406 A CA 3126406A CA 3126406 A CA3126406 A CA 3126406A CA 3126406 A1 CA3126406 A1 CA 3126406A1
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Prior art keywords
creatinine
active area
glucose
responsive active
membrane
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Pending
Application number
CA3126406A
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English (en)
French (fr)
Inventor
Tianmei Ouyang
Benjamin J. Feldman
Hyun Cho
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Abbott Diabetes Care Inc
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Abbott Diabetes Care Inc
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Application filed by Abbott Diabetes Care Inc filed Critical Abbott Diabetes Care Inc
Publication of CA3126406A1 publication Critical patent/CA3126406A1/en
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    • A—HUMAN NECESSITIES
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    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14503—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/28—Electrolytic cell components
    • G01N27/30—Electrodes, e.g. test electrodes; Half-cells
    • G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
    • G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
    • A—HUMAN NECESSITIES
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    • A61B5/14507—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue specially adapted for measuring characteristics of body fluids other than blood
    • A61B5/1451—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for interstitial fluid
    • A—HUMAN NECESSITIES
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    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61B5/14546—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring analytes not otherwise provided for, e.g. ions, cytochromes
    • A—HUMAN NECESSITIES
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    • A61B5/1468—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means
    • A61B5/1473—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means invasive, e.g. introduced into the body by a catheter
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    • A61B5/1468—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means
    • A61B5/1473—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means invasive, e.g. introduced into the body by a catheter
    • A61B5/14735—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means invasive, e.g. introduced into the body by a catheter comprising an immobilised reagent
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    • A61B5/1468—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means
    • A61B5/1486—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means using enzyme electrodes, e.g. with immobilised oxidase
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    • A61B5/1486—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means using enzyme electrodes, e.g. with immobilised oxidase
    • A61B5/14865—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means using enzyme electrodes, e.g. with immobilised oxidase invasive, e.g. introduced into the body by a catheter or needle or using implanted sensors
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    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • C12Q1/005—Enzyme electrodes involving specific analytes or enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/001—Enzyme electrodes
    • C12Q1/005—Enzyme electrodes involving specific analytes or enzymes
    • C12Q1/006—Enzyme electrodes involving specific analytes or enzymes for glucose
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/26—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving oxidoreductase
    • G—PHYSICS
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    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
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    • G—PHYSICS
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    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/70—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving creatine or creatinine
    • A—HUMAN NECESSITIES
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    • C12Y—ENZYMES
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    • C12Y101/03—Oxidoreductases acting on the CH-OH group of donors (1.1) with a oxygen as acceptor (1.1.3)
    • C12Y101/03004—Glucose oxidase (1.1.3.4)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
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    • C12Y105/03—Oxidoreductases acting on the CH-NH group of donors (1.5) with oxygen as acceptor (1.5.3)
    • C12Y105/03001—Sarcosine oxidase (1.5.3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
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    • C12Y305/02—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in cyclic amides (3.5.2)
    • C12Y305/0201—Creatininase (3.5.2.10)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
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    • C12Y305/03003—Creatinase (3.5.3.3), i.e. creatine amidinohydrolase
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    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/978—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
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  • General Health & Medical Sciences (AREA)
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  • Medical Informatics (AREA)
  • Heart & Thoracic Surgery (AREA)
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  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
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  • General Chemical & Material Sciences (AREA)
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  • General Engineering & Computer Science (AREA)
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  • Urology & Nephrology (AREA)
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  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
CA3126406A 2019-01-28 2019-09-25 Analyte sensors and sensing methods for detecting creatinine Pending CA3126406A1 (en)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201962797566P 2019-01-28 2019-01-28
US62/797,566 2019-01-28
US201962884841P 2019-08-09 2019-08-09
US201962884869P 2019-08-09 2019-08-09
US62/884,869 2019-08-09
US62/884,841 2019-08-09
US16/582,583 US20200241015A1 (en) 2019-01-28 2019-09-25 Analyte Sensors and Sensing Methods for Detecting Creatinine
US16/582,583 2019-09-25
PCT/US2019/052942 WO2020159584A1 (en) 2019-01-28 2019-09-25 Analyte sensors and sensing methods for detecting creatinine

Publications (1)

Publication Number Publication Date
CA3126406A1 true CA3126406A1 (en) 2020-08-06

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CA3126406A Pending CA3126406A1 (en) 2019-01-28 2019-09-25 Analyte sensors and sensing methods for detecting creatinine

Country Status (8)

Country Link
US (1) US20200241015A1 (https=)
EP (2) EP4552566A1 (https=)
JP (4) JP7135218B2 (https=)
CN (2) CN113518584B (https=)
AU (2) AU2019427806B2 (https=)
CA (1) CA3126406A1 (https=)
ES (1) ES2999057T3 (https=)
WO (1) WO2020159584A1 (https=)

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CN113453620B (zh) 2019-01-28 2024-03-05 美国雅培糖尿病护理公司 用于双重检测葡萄糖和乙醇的分析物传感器和感测方法
CA3126240A1 (en) 2019-01-28 2020-08-06 Abbott Diabetes Cares Inc. Analyte sensors employing multiple enzymes and methods associated therewith
EP4552566A1 (en) * 2019-01-28 2025-05-14 Abbott Diabetes Care, Inc. Analyte sensors and sensing methods for detecting creatinine
EP4574038A3 (en) 2019-01-28 2025-08-27 Abbott Diabetes Care, Inc. Analyte sensors and sensing methods featuring dual detection of glucose and ketones
CN115038381A (zh) 2020-01-03 2022-09-09 美国雅培糖尿病护理公司 用于检测多种分析物的传感器阵列系统和方法
JP7397222B2 (ja) 2020-05-29 2023-12-12 アボット ダイアベティス ケア インコーポレイテッド ジアホラーゼの阻害剤を検出するための分析物センサおよびセンシング方法
EP4165400A4 (en) 2020-06-16 2024-07-10 Abbott Diabetes Care Inc. ANALYTICAL SENSORS WITH WORKING ELECTRODE APERITY PLANING TO REDUCE INTERFERING SIGNALS
CA3181614A1 (en) 2020-06-16 2021-12-23 Abbott Diabetes Care Inc. Analyte sensors featuring a reduced-area working electrode for decreasing interferent signal
JP2023534645A (ja) 2020-07-08 2023-08-10 アボット ダイアベティス ケア インコーポレイテッド 干渉信号を低減するための強化を特徴とする検体センサ
AU2021410547B2 (en) 2020-12-23 2025-12-18 Abbott Diabetes Care Inc. Analyte sensors with reduced interferent signal and methods
WO2023178170A2 (en) * 2022-03-16 2023-09-21 Senseonics, Incorporated Catalytic reactive oxygen species scavenger hydrogel
WO2023235444A1 (en) * 2022-06-01 2023-12-07 Dexcom, Inc. Systems and methods for optimizing treatment using physiological profiles
CN120201995A (zh) 2022-12-30 2025-06-24 雅培糖尿病护理公司 药物递送组合物和控制皮下传感器的药物递送速率的方法
EP4655412A2 (en) 2023-01-25 2025-12-03 Abbott Diabetes Care, Inc. Temperature-insensitive membranes for analyte sensors
CN121174989A (zh) 2023-05-24 2025-12-19 雅培糖尿病护理公司 用于将治疗剂结合到分析物传感器中的方法
WO2025040616A1 (en) * 2023-08-22 2025-02-27 Roche Diagnostics Gmbh Sensor for detecting a plurality of analytes

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