CA3108071A1 - Anticorps anti-cxcr2 et leurs utilisations - Google Patents
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
Abstract
L'invention concerne des molécules d'anticorps humains qui se lient de manière immunospécifique à CXCR2 humain. Les molécules d'anticorps humain selon l'invention sont des antagonistes puissants et sélectifs des fonctions de CXCR2 et empêchent le recrutement de neutrophiles dans des tissus sans appauvrir fortement le nombre de neutrophiles en circulation. L'invention concerne également des compositions pharmaceutiques, des molécules d'acide nucléique, des vecteurs, des cellules et des utilisations des anticorps selon l'invention.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862713095P | 2018-08-01 | 2018-08-01 | |
| US62/713,095 | 2018-08-01 | ||
| PCT/US2019/044314 WO2020028479A1 (fr) | 2018-08-01 | 2019-07-31 | Anticorps anti-cxcr2 et leurs utilisations |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3108071A1 true CA3108071A1 (fr) | 2020-02-06 |
Family
ID=67614672
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3108071A Pending CA3108071A1 (fr) | 2018-08-01 | 2019-07-31 | Anticorps anti-cxcr2 et leurs utilisations |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US11332534B2 (fr) |
| EP (1) | EP3830124A1 (fr) |
| JP (2) | JP7473531B2 (fr) |
| KR (1) | KR20210041586A (fr) |
| CN (1) | CN112955463A (fr) |
| AU (1) | AU2019312576A1 (fr) |
| BR (1) | BR112021001683A2 (fr) |
| CA (1) | CA3108071A1 (fr) |
| IL (1) | IL280321A (fr) |
| MX (1) | MX2021001305A (fr) |
| SG (1) | SG11202100663VA (fr) |
| WO (1) | WO2020028479A1 (fr) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022056329A1 (fr) * | 2020-09-10 | 2022-03-17 | Immunome, Inc. | Anticorps ciblant la sous-famille snx9 |
| EP4063384A1 (fr) * | 2021-03-23 | 2022-09-28 | Ceinge Biotecnologie Avanzate SCarl | Protéines humaines neutralisantes spécifiques de l'antigène spike-rbd du sars-cov-2 |
| WO2022228380A1 (fr) * | 2021-04-26 | 2022-11-03 | Kaohsiung Medical University | Anticorps anti-cxcr2 et leurs utilisations |
| WO2024003360A1 (fr) | 2022-07-01 | 2024-01-04 | Institut Curie | Biomarqueurs et leurs utilisations pour le traitement du neuroblastome |
| WO2024026528A1 (fr) * | 2022-08-02 | 2024-02-08 | Dimerix Bioscience Pty Ltd | Régime posologique pour le traitement de la bpco |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3785186T2 (de) | 1986-09-02 | 1993-07-15 | Enzon Lab Inc | Bindungsmolekuele mit einzelpolypeptidkette. |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| US5440021A (en) * | 1991-03-29 | 1995-08-08 | Chuntharapai; Anan | Antibodies to human IL-8 type B receptor |
| EP0672142B1 (fr) | 1992-12-04 | 2001-02-28 | Medical Research Council | Proteines de liaison multivalentes et multispecifiques, leur fabrication et leur utilisation |
| AUPO591797A0 (en) | 1997-03-27 | 1997-04-24 | Commonwealth Scientific And Industrial Research Organisation | High avidity polyvalent and polyspecific reagents |
| NL1003537C2 (nl) | 1996-07-08 | 1998-01-12 | Holland Railconsult B V | Werkwijze voor het vervaardigen van een gebogen beglazing. |
| ES2521140T3 (es) | 2004-07-22 | 2014-11-12 | Genentech, Inc. | Composición de anticuerpos de HER2 |
| KR101661357B1 (ko) | 2007-06-01 | 2016-09-29 | 오픈 모노클로날 테크놀로지, 인코포레이티드 | 내생적 면역글로불린 유전자를 억제하고 트랜스제닉 인간 이디오타입 항체를 생산하기 위한 방법 및 조성물 |
| WO2009073631A2 (fr) * | 2007-11-30 | 2009-06-11 | Kalobios Pharmaceuticals, Inc. | Anticorps dirigés contre l'antigène pcrv de pseudomonas aeruginosa |
| ES2564523T3 (es) | 2007-12-19 | 2016-03-23 | Janssen Biotech, Inc. | Diseño y generación de bibliotecas de presentación en fago por pIX de novo humanas mediante fusión con pIX o pVII, vectores, anticuerpos y métodos |
| TWI619811B (zh) * | 2010-11-08 | 2018-04-01 | 諾華公司 | 趨化細胞素受體結合多肽 |
| US9328174B2 (en) * | 2012-05-09 | 2016-05-03 | Novartis Ag | Chemokine receptor binding polypeptides |
| WO2014170317A1 (fr) | 2013-04-17 | 2014-10-23 | Morphosys Ag | Anticorps ciblant spécifiquement le cxcr2 humain |
| WO2015169811A2 (fr) | 2014-05-06 | 2015-11-12 | Medimmune Limited | Molécules se liant au récepteur 2 de la chimiokine anti cxc et leurs utilisations |
| BR112018002570A2 (pt) * | 2015-10-02 | 2018-10-16 | Hoffmann La Roche | molécula de ligação ao antígeno biespecífica, anticorpo biespecífico, polinucleotídeos, anticorpo que se liga especificamente ao ox40, composição farmacêutica e método para inibir o crescimento de células tumorais em um indivíduo |
| US11053319B2 (en) | 2017-02-27 | 2021-07-06 | Monash University | CXCR2 antibodies and uses thereof |
-
2019
- 2019-07-31 AU AU2019312576A patent/AU2019312576A1/en active Pending
- 2019-07-31 CA CA3108071A patent/CA3108071A1/fr active Pending
- 2019-07-31 MX MX2021001305A patent/MX2021001305A/es unknown
- 2019-07-31 WO PCT/US2019/044314 patent/WO2020028479A1/fr unknown
- 2019-07-31 SG SG11202100663VA patent/SG11202100663VA/en unknown
- 2019-07-31 KR KR1020217006231A patent/KR20210041586A/ko unknown
- 2019-07-31 US US16/527,354 patent/US11332534B2/en active Active
- 2019-07-31 BR BR112021001683-0A patent/BR112021001683A2/pt unknown
- 2019-07-31 EP EP19752827.6A patent/EP3830124A1/fr active Pending
- 2019-07-31 JP JP2021505426A patent/JP7473531B2/ja active Active
- 2019-07-31 CN CN201980051263.6A patent/CN112955463A/zh active Pending
-
2021
- 2021-01-21 IL IL280321A patent/IL280321A/en unknown
-
2022
- 2022-04-12 US US17/718,622 patent/US20220348671A1/en active Pending
-
2024
- 2024-01-11 JP JP2024002600A patent/JP2024026724A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| IL280321A (en) | 2021-03-01 |
| KR20210041586A (ko) | 2021-04-15 |
| JP2021532789A (ja) | 2021-12-02 |
| WO2020028479A1 (fr) | 2020-02-06 |
| BR112021001683A2 (pt) | 2021-05-04 |
| MX2021001305A (es) | 2021-06-23 |
| CN112955463A (zh) | 2021-06-11 |
| JP7473531B2 (ja) | 2024-04-23 |
| EP3830124A1 (fr) | 2021-06-09 |
| JP2024026724A (ja) | 2024-02-28 |
| SG11202100663VA (en) | 2021-02-25 |
| US20220348671A1 (en) | 2022-11-03 |
| AU2019312576A1 (en) | 2021-02-25 |
| US11332534B2 (en) | 2022-05-17 |
| US20200040089A1 (en) | 2020-02-06 |
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