CA3106484C - A salt of an lsd1 inhibitor and its crystal form - Google Patents
A salt of an lsd1 inhibitor and its crystal form Download PDFInfo
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- CA3106484C CA3106484C CA3106484A CA3106484A CA3106484C CA 3106484 C CA3106484 C CA 3106484C CA 3106484 A CA3106484 A CA 3106484A CA 3106484 A CA3106484 A CA 3106484A CA 3106484 C CA3106484 C CA 3106484C
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- crystal form
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- compound iii
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- 229910000033 sodium borohydride Inorganic materials 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- AKHNMLFCWUSKQB-UHFFFAOYSA-L sodium thiosulfate Chemical class [Na+].[Na+].[O-]S([O-])(=O)=S AKHNMLFCWUSKQB-UHFFFAOYSA-L 0.000 description 1
- 239000012321 sodium triacetoxyborohydride Substances 0.000 description 1
- 239000011877 solvent mixture Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000010189 synthetic method Methods 0.000 description 1
- 210000004881 tumor cell Anatomy 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
- 230000004584 weight gain Effects 0.000 description 1
- 235000019786 weight gain Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810804068.3 | 2018-07-20 | ||
| CN201810804068 | 2018-07-20 | ||
| PCT/CN2019/096842 WO2020015745A1 (zh) | 2018-07-20 | 2019-07-19 | 一种lsd1抑制剂的盐及其晶型 |
Publications (2)
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| CA3106484A1 CA3106484A1 (en) | 2020-01-23 |
| CA3106484C true CA3106484C (en) | 2024-06-25 |
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| CA3106484A Active CA3106484C (en) | 2018-07-20 | 2019-07-19 | A salt of an lsd1 inhibitor and its crystal form |
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| CA (1) | CA3106484C (enExample) |
| WO (1) | WO2020015745A1 (enExample) |
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| WO2021228146A1 (zh) * | 2020-05-12 | 2021-11-18 | 石药集团中奇制药技术（石家庄）有限公司 | 一种lsd1抑制剂的用途 |
| CA3231846A1 (en) | 2021-04-08 | 2022-10-13 | Tamara Maes | Combinations of lsd1 inhibitors for treating myeloid cancers |
| CN119497613A (zh) | 2022-05-09 | 2025-02-21 | 奥莱松基因组股份有限公司 | 使用lsd1抑制剂治疗nf1-突变肿瘤的方法 |
| EP4522136A1 (en) | 2022-05-09 | 2025-03-19 | Oryzon Genomics, S.A. | Methods of treating malignant peripheral nerve sheath tumor (mpnst) using lsd1 inhibitors |
| AU2023385514A1 (en) | 2022-11-24 | 2025-07-10 | Oryzon Genomics, S.A. | Combinations of lsd1 inhibitors and menin inhibitors for treating cancer |
| CN116069221A (zh) * | 2022-12-27 | 2023-05-05 | 北京字跳网络技术有限公司 | 媒体内容的展示方法、装置、电子设备和存储介质 |
| TW202508595A (zh) | 2023-05-04 | 2025-03-01 | 美商銳新醫藥公司 | 用於ｒａｓ相關疾病或病症之組合療法 |
| WO2025034702A1 (en) | 2023-08-07 | 2025-02-13 | Revolution Medicines, Inc. | Rmc-6291 for use in the treatment of ras protein-related disease or disorder |
| WO2025080946A2 (en) | 2023-10-12 | 2025-04-17 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2025171296A1 (en) | 2024-02-09 | 2025-08-14 | Revolution Medicines, Inc. | Ras inhibitors |
| WO2025240847A1 (en) | 2024-05-17 | 2025-11-20 | Revolution Medicines, Inc. | Ras inhibitors |
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| FR2705675B1 (fr) * | 1993-05-27 | 1996-05-03 | Smithkline Beecham Labo Pharma | Nouveaux composés, leur procédé de préparation et leur utilisation en tant que médicaments. |
| WO2010084160A1 (en) * | 2009-01-21 | 2010-07-29 | Oryzon Genomics S.A. | Phenylcyclopropylamine derivatives and their medical use |
| ES2607081T3 (es) | 2010-04-19 | 2017-03-29 | Oryzon Genomics, S.A. | Inhibidores de desmetilasa específica de lisina-1 y su uso |
| LT2598482T (lt) | 2010-07-29 | 2018-07-10 | Oryzon Genomics, S.A. | Demetilazės lsd1 inhibitoriai arilciklopropilamino pagrindu ir jų medicininis panaudojimas |
| CN103857393B (zh) | 2011-03-25 | 2016-08-17 | 葛兰素史密斯克莱知识产权（第2号）有限公司 | 环丙基胺作为lsd1抑制剂 |
| KR102710120B1 (ko) * | 2015-08-12 | 2024-09-27 | 인사이트 홀딩스 코포레이션 | Lsd1 저해제의 염 |
| PE20190377A1 (es) * | 2016-04-22 | 2019-03-08 | Incyte Corp | Formulaciones de un inhibidor de lsd 1 |
| CA3022561A1 (en) | 2016-05-09 | 2017-11-16 | Sridharan Rajagopal | Cyclopropyl-amide compounds as dual lsd1/hdac inhibitors |
| RU2763898C9 (ru) | 2017-01-24 | 2022-03-18 | Цспц Чжунци Фармасьютикал Текнолоджи (Шицзячжуан) Ко., Лтд. | Ингибитор lsd1, а также способ его получения и его применение |
-
2019
- 2019-07-19 CN CN201980047189.0A patent/CN112424175B/zh active Active
- 2019-07-19 AU AU2019303777A patent/AU2019303777B2/en active Active
- 2019-07-19 CA CA3106484A patent/CA3106484C/en active Active
- 2019-07-19 KR KR1020217005112A patent/KR102778948B1/ko active Active
- 2019-07-19 JP JP2021525358A patent/JP7358466B2/ja active Active
- 2019-07-19 US US17/261,322 patent/US12024494B2/en active Active
- 2019-07-19 EP EP19837636.0A patent/EP3825309B1/en active Active
- 2019-07-19 WO PCT/CN2019/096842 patent/WO2020015745A1/zh not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| EP3825309A4 (en) | 2022-03-23 |
| US20210317096A1 (en) | 2021-10-14 |
| CN112424175A (zh) | 2021-02-26 |
| CA3106484A1 (en) | 2020-01-23 |
| KR102778948B1 (ko) | 2025-03-07 |
| AU2019303777A1 (en) | 2021-02-11 |
| JP7358466B2 (ja) | 2023-10-10 |
| CN112424175B (zh) | 2022-10-28 |
| AU2019303777B2 (en) | 2023-01-19 |
| JP2021530565A (ja) | 2021-11-11 |
| US12024494B2 (en) | 2024-07-02 |
| KR20210034058A (ko) | 2021-03-29 |
| EP3825309A1 (en) | 2021-05-26 |
| EP3825309B1 (en) | 2023-09-06 |
| WO2020015745A1 (zh) | 2020-01-23 |
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