CA3104940A1 - Liquid pharmaceutical composition comprising adalimumab - Google Patents
Liquid pharmaceutical composition comprising adalimumabInfo
- Publication number
- CA3104940A1 CA3104940A1 CA3104940A CA3104940A CA3104940A1 CA 3104940 A1 CA3104940 A1 CA 3104940A1 CA 3104940 A CA3104940 A CA 3104940A CA 3104940 A CA3104940 A CA 3104940A CA 3104940 A1 CA3104940 A1 CA 3104940A1
- Authority
- CA
- Canada
- Prior art keywords
- suitably
- liquid pharmaceutical
- pharmaceutical composition
- adalimumab
- citrate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
- 239000007788 liquid Substances 0.000 title claims abstract description 248
- 239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 246
- 229960002964 adalimumab Drugs 0.000 title claims abstract description 170
- 239000000203 mixture Substances 0.000 claims abstract description 342
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- 239000006172 buffering agent Substances 0.000 claims abstract description 105
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims abstract description 90
- 239000003381 stabilizer Substances 0.000 claims abstract description 72
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- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims abstract description 59
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- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims abstract description 48
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Classifications
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- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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Landscapes
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- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP14169755.7 | 2014-05-23 | ||
| EP14169755.7A EP2946767B1 (en) | 2014-05-23 | 2014-05-23 | Liquid pharmaceutical composition |
| CA2948746A CA2948746C (en) | 2014-05-23 | 2015-05-15 | Liquid pharmaceutical composition comprising adalimumab |
Related Parent Applications (1)
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| ES2600488T3 (es) | 2014-05-23 | 2017-02-09 | Ares Trading S.A. | Composición farmacéutica líquida |
| EP2946766B1 (en) | 2014-05-23 | 2016-03-02 | Ares Trading S.A. | Liquid pharmaceutical composition |
| CN105543204A (zh) * | 2015-12-30 | 2016-05-04 | 海口奇力制药股份有限公司 | 一种组合物及其应用、含有该组合物的稳定剂 |
| WO2017177160A1 (en) | 2016-04-07 | 2017-10-12 | Nevakar Llc | Formulation for use in a method of treatment of pain |
| EP4467565A3 (en) | 2016-12-21 | 2025-03-12 | Amgen Inc. | Anti-tnf alpha antibody formulations |
| BR112019021723A2 (pt) * | 2017-04-18 | 2021-06-29 | Dr. Reddy's Laboratories Limited | formulação de anticorpo líquida estável, anticorpo na formulação, formulação líquida estável de anticorpo anti-il6r, formulação líquida estável de tocilizumab em sistema de tampão de fosfato-aminoácido, e, formulação líquida estável de tocilizumab |
| CN111432882A (zh) * | 2017-10-03 | 2020-07-17 | 内瓦卡公司 | 对乙酰氨基酚-普瑞巴林组合和治疗疼痛的方法 |
| MX2017016884A (es) * | 2017-12-19 | 2019-06-20 | Probiomed S A De C V | Formulacion farmaceutica estable de una proteina anti-tnfa. |
| CA3106669A1 (en) * | 2018-07-20 | 2020-01-30 | Momenta Pharmaceuticals, Inc. | Compositions of fcrn antibodies and methods of use thereof |
| CN113134081A (zh) * | 2020-01-20 | 2021-07-20 | 上海君实生物医药科技股份有限公司 | 抗btla抗体药物组合物及其用途 |
| IL319755A (en) * | 2022-10-07 | 2025-05-01 | Annexon Inc | Anti-C1Q antibody formulations |
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| IN2014MU01248A (OSRAM) | 2014-04-02 | 2015-10-09 | Intas Pharmaceuticals Ltd | |
| EP2946766B1 (en) | 2014-05-23 | 2016-03-02 | Ares Trading S.A. | Liquid pharmaceutical composition |
| ES2600488T3 (es) * | 2014-05-23 | 2017-02-09 | Ares Trading S.A. | Composición farmacéutica líquida |
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2015
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- 2015-05-15 WO PCT/EP2015/060818 patent/WO2015177059A1/en not_active Ceased
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- 2015-05-15 HR HRP20201242TT patent/HRP20201242T1/hr unknown
- 2015-05-15 EP EP20186550.8A patent/EP3741358A1/en not_active Withdrawn
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2016
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2021
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