CA3097246C - Processus d`obtention d`une solution alcaloide psychoactive purifiee - Google Patents

Processus d`obtention d`une solution alcaloide psychoactive purifiee Download PDF

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Publication number
CA3097246C
CA3097246C CA3097246A CA3097246A CA3097246C CA 3097246 C CA3097246 C CA 3097246C CA 3097246 A CA3097246 A CA 3097246A CA 3097246 A CA3097246 A CA 3097246A CA 3097246 C CA3097246 C CA 3097246C
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CA
Canada
Prior art keywords
psychoactive
purified
alkaloid
solvent
psychoactive alkaloid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA3097246A
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English (en)
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CA3097246A1 (fr
Inventor
Ryan Moss
Benjamin Lightburn
Lisa Ranken
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Psilo Scientific Ltd
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Psilo Scientific Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to CA3097246A priority Critical patent/CA3097246C/fr
Application filed by Psilo Scientific Ltd filed Critical Psilo Scientific Ltd
Priority to IL298561A priority patent/IL298561A/en
Priority to PCT/CA2021/050813 priority patent/WO2021253116A1/fr
Priority to EP21825817.6A priority patent/EP4161546A1/fr
Priority to IL299450A priority patent/IL299450A/en
Priority to AU2021290454A priority patent/AU2021290454B2/en
Priority to IL299449A priority patent/IL299449A/en
Priority to CA3137016A priority patent/CA3137016C/fr
Priority to MX2022016533A priority patent/MX2022016533A/es
Priority to BR112022025780A priority patent/BR112022025780A2/pt
Priority to CA3173030A priority patent/CA3173030C/fr
Priority to IL297791A priority patent/IL297791A/en
Priority to IL299448A priority patent/IL299448A/en
Priority to IL299453A priority patent/IL299453A/en
Priority to IL299452A priority patent/IL299452A/en
Priority to IL305632A priority patent/IL305632A/en
Priority to CA3169140A priority patent/CA3169140A1/fr
Priority to IL299451A priority patent/IL299451A/en
Priority to US17/348,697 priority patent/US11331357B2/en
Priority to US17/351,149 priority patent/US11382942B2/en
Priority to US17/483,601 priority patent/US11298388B2/en
Priority to PCT/CA2021/051495 priority patent/WO2022082320A1/fr
Priority to BR112022025782A priority patent/BR112022025782A2/pt
Priority to MX2023004350A priority patent/MX2023004350A/es
Priority to EP21881426.7A priority patent/EP4161549A4/fr
Publication of CA3097246A1 publication Critical patent/CA3097246A1/fr
Priority to US17/587,731 priority patent/US11510952B2/en
Priority to US17/697,798 priority patent/US11571450B2/en
Priority to US17/702,701 priority patent/US11642385B2/en
Priority to AU2022291411A priority patent/AU2022291411B2/en
Priority to AU2022291410A priority patent/AU2022291410B2/en
Priority to AU2022291414A priority patent/AU2022291414B2/en
Priority to AU2022291413A priority patent/AU2022291413B2/en
Priority to AU2022291416A priority patent/AU2022291416B2/en
Application granted granted Critical
Publication of CA3097246C publication Critical patent/CA3097246C/fr
Priority to AU2023285751A priority patent/AU2023285751A1/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/02—Solvent extraction of solids
    • B01D11/0288—Applications, solvents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/02—Solvent extraction of solids
    • B01D11/0215—Solid material in other stationary receptacles
    • B01D11/0253—Fluidised bed of solid materials
    • B01D11/0257—Fluidised bed of solid materials using mixing mechanisms, e.g. stirrers, jets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D11/00—Solvent extraction
    • B01D11/02—Solvent extraction of solids
    • B01D11/028—Flow sheets
    • B01D11/0284—Multistage extraction
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/12—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the preparation of the feed
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/16—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the fluid carrier
    • B01D15/166—Fluid composition conditioning, e.g. gradient
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction
    • B01D15/361—Ion-exchange
    • B01D15/362—Cation-exchange
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction
    • B01D15/361—Ion-exchange
    • B01D15/363—Anion-exchange
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Mycology (AREA)
  • Medical Informatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Botany (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Une source dalcaloïde psychoactif est utilisée pour obtenir un extrait dalcaloïde psychoactif. La source peut être constituée de champignons, danimaux ou de plantes psychédéliques ou dun extrait antérieur de ceux-ci. Les alcaloïdes psychoactifs dans lextrait sont adsorbés sur un matériau adsorbant, à partir duquel ils sont ensuite élués pour fournir une solution purifiée dalcaloïde psychoactif. Le procédé peut être répété avec différents matériaux adsorbants, différentes valeurs de pH et différents solvants délution. Les solides présents dans lextrait sont éliminés à différents stades par filtration ou centrifugation. La solution purifiée dalcaloïde psychoactif peut ensuite être concentrée en une suspension, puis normalisée par ajout dexcipients et évaporation du solvant. Lextrait standardisé résultant présente une concentration spécifiée en alcaloïde psychoactif.
CA3097246A 2019-06-17 2020-10-23 Processus d`obtention d`une solution alcaloide psychoactive purifiee Active CA3097246C (fr)

Priority Applications (34)

Application Number Priority Date Filing Date Title
CA3097246A CA3097246C (fr) 2020-10-23 2020-10-23 Processus d`obtention d`une solution alcaloide psychoactive purifiee
PCT/CA2021/050813 WO2021253116A1 (fr) 2020-06-17 2021-06-14 Compositions comprenant des composés psychoactifs à partir d'organismes psychoactifs
EP21825817.6A EP4161546A1 (fr) 2020-06-17 2021-06-14 Compositions comprenant des composés psychoactifs à partir d'organismes psychoactifs
IL299450A IL299450A (en) 2020-06-17 2021-06-14 Dephosphorylation-controlled extraction of phosphorylatable psychoactive alkaloids
AU2021290454A AU2021290454B2 (en) 2020-06-17 2021-06-14 Process for Obtaining a Purified Psychoactive Alkaloid Solution
IL299449A IL299449A (en) 2020-06-17 2021-06-14 Standard psychoactive alkaloid extract composition
IL298561A IL298561A (en) 2020-06-17 2021-06-14 Methanol-based extraction of psychoactive compounds from a mushroom
MX2022016533A MX2022016533A (es) 2020-06-17 2021-06-14 Composiciones que comprenden compuestos psicoactivos de organismos psicoactivos.
BR112022025780A BR112022025780A2 (pt) 2020-06-17 2021-06-14 Método para gerar um extrato de alcaloide psicoativo, método para gerar um extrato de alcaloide psicoativo fosforilado e método para gerar um extrato de alcaloide psicoativo desfosforilado
CA3173030A CA3173030C (fr) 2020-06-17 2021-06-14 Extraction d'alcaloide psychoactif principalement phosphoryle au moyen d'alcali
IL297791A IL297791A (en) 2020-06-17 2021-06-14 Compounds composed of psychoactive compounds from psychoactive organisms
IL299448A IL299448A (en) 2020-06-17 2021-06-14 A process for obtaining a purified psychoactive alkaloid solution
IL299453A IL299453A (en) 2020-06-17 2021-06-14 Extraction and composition of psychoactive alkaloids with inhibited dephosphorylation
IL299452A IL299452A (en) 2020-06-17 2021-06-14 Extraction and composition of psychoactive alkaloids with controlled dephosphorylation
IL305632A IL305632A (en) 2020-06-17 2021-06-14 Extraction of psychoactive compounds from psychedelic mushrooms
CA3169140A CA3169140A1 (fr) 2019-06-17 2021-06-14 Extraction d'alcaloides psychoactifs capables de phosphorylation a dephosphorylation controlee
IL299451A IL299451A (en) 2020-06-17 2021-06-14 Extraction of a psychoactive alkaloid is mainly by means of alkali
CA3137016A CA3137016C (fr) 2019-06-17 2021-06-14 Extraction d'alcaloide psychoactif et composition avec dephosphorylationattenuees
US17/348,697 US11331357B2 (en) 2020-06-17 2021-06-15 Methods and compositions comprising psychoactive compounds from psychoactive organisms
US17/351,149 US11382942B2 (en) 2020-06-17 2021-06-17 Extraction of psychoactive compounds from psilocybin fungus
US17/483,601 US11298388B2 (en) 2020-06-17 2021-09-23 Psychoactive alkaloid extraction and composition with controlled dephosphorylation
PCT/CA2021/051495 WO2022082320A1 (fr) 2020-10-23 2021-10-23 Procédé d'obtention d'une solution purifiée d'alcaloïde psychoactif
BR112022025782A BR112022025782A2 (pt) 2020-10-23 2021-10-23 Processo para obtenção de uma solução de alcaloide psicoativo purificada
MX2023004350A MX2023004350A (es) 2020-10-23 2021-10-23 Proceso para la obtencion de una solucion de alcaloide psicoactivo purificada.
EP21881426.7A EP4161549A4 (fr) 2020-10-23 2021-10-23 Procédé d'obtention d'une solution purifiée d'alcaloïde psychoactif
US17/587,731 US11510952B2 (en) 2020-06-17 2022-01-28 Ethanol extraction of psychoactive compounds from psilocybin fungus
US17/697,798 US11571450B2 (en) 2020-06-17 2022-03-17 Aqueous extraction of psychoactive compounds from psilocybin fungus
US17/702,701 US11642385B2 (en) 2020-06-17 2022-03-23 Basic extraction of psychoactive compounds from psychoactive organisms
AU2022291411A AU2022291411B2 (en) 2020-06-17 2022-12-19 Psychoactive alkaloid extraction and composition with inhibited dephosphorylation
AU2022291410A AU2022291410B2 (en) 2020-06-17 2022-12-19 Standardized psychoactive alkaloid extract composition
AU2022291414A AU2022291414B2 (en) 2020-06-17 2022-12-19 Psychoactive alkaloid extraction and composition with controlled dephosphorylation
AU2022291413A AU2022291413B2 (en) 2020-06-17 2022-12-19 Predominantly phosphorylated psychoactive alkaloid extraction using alkali
AU2022291416A AU2022291416B2 (en) 2020-06-17 2022-12-19 Dephosphorylation-controlled extraction of phosphorylatable psychoactive alkaloids
AU2023285751A AU2023285751A1 (en) 2020-06-17 2023-12-19 Powdered Composition Containing a Mushroom Extract Comprising a Psychoactive Alkaloid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CA3097246A CA3097246C (fr) 2020-10-23 2020-10-23 Processus d`obtention d`une solution alcaloide psychoactive purifiee

Publications (2)

Publication Number Publication Date
CA3097246A1 CA3097246A1 (fr) 2021-11-12
CA3097246C true CA3097246C (fr) 2023-03-28

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Family Applications (1)

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CA3097246A Active CA3097246C (fr) 2019-06-17 2020-10-23 Processus d`obtention d`une solution alcaloide psychoactive purifiee

Country Status (1)

Country Link
CA (1) CA3097246C (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11992476B2 (en) 2021-07-01 2024-05-28 Psilo Scientific Ltd Transdermal psychoactive alkaloid composition and preparation thereof

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2021290454B2 (en) 2020-06-17 2024-01-11 Psilo Scientific Ltd Process for Obtaining a Purified Psychoactive Alkaloid Solution
CA3197443A1 (fr) 2020-12-28 2022-06-28 Psilo Scientific Ltd. Procedes d'extraction d'alcaloides psychoactifs et preparation connexe en formes transmucosales
CN115739028B (zh) * 2022-11-26 2024-04-02 西南政法大学 一种精神活性物质吸附剂及其应用

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11992476B2 (en) 2021-07-01 2024-05-28 Psilo Scientific Ltd Transdermal psychoactive alkaloid composition and preparation thereof

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Publication number Publication date
CA3097246A1 (fr) 2021-11-12

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