CA3096984A1 - Axl kinase inhibitors and use of the same - Google Patents
Axl kinase inhibitors and use of the same Download PDFInfo
- Publication number
- CA3096984A1 CA3096984A1 CA3096984A CA3096984A CA3096984A1 CA 3096984 A1 CA3096984 A1 CA 3096984A1 CA 3096984 A CA3096984 A CA 3096984A CA 3096984 A CA3096984 A CA 3096984A CA 3096984 A1 CA3096984 A1 CA 3096984A1
- Authority
- CA
- Canada
- Prior art keywords
- subject
- compound
- cancer
- inhibitor
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/453—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/235—Saturated compounds containing more than one carboxyl group
- C07C59/245—Saturated compounds containing more than one carboxyl group containing hydroxy or O-metal groups
- C07C59/255—Tartaric acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/48—Two nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (21)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201862653394P | 2018-04-05 | 2018-04-05 | |
| US62/653,394 | 2018-04-05 | ||
| US201862663146P | 2018-04-26 | 2018-04-26 | |
| US62/663,146 | 2018-04-26 | ||
| US201862678980P | 2018-05-31 | 2018-05-31 | |
| US62/678,980 | 2018-05-31 | ||
| US201862688161P | 2018-06-21 | 2018-06-21 | |
| US62/688,161 | 2018-06-21 | ||
| US201862695609P | 2018-07-09 | 2018-07-09 | |
| US62/695,609 | 2018-07-09 | ||
| US201862698638P | 2018-07-16 | 2018-07-16 | |
| US62/698,638 | 2018-07-16 | ||
| US201862760882P | 2018-11-13 | 2018-11-13 | |
| US62/760,882 | 2018-11-13 | ||
| US201862767475P | 2018-11-14 | 2018-11-14 | |
| US62/767,475 | 2018-11-14 | ||
| US201862778856P | 2018-12-12 | 2018-12-12 | |
| US62/778,856 | 2018-12-12 | ||
| US201962813705P | 2019-03-04 | 2019-03-04 | |
| US62/813,705 | 2019-03-04 | ||
| PCT/US2019/026094 WO2019195753A1 (en) | 2018-04-05 | 2019-04-05 | Axl kinase inhibitors and use of the same |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3096984A1 true CA3096984A1 (en) | 2019-10-10 |
Family
ID=68101236
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3096984A Pending CA3096984A1 (en) | 2018-04-05 | 2019-04-05 | Axl kinase inhibitors and use of the same |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US11013741B1 (enExample) |
| EP (1) | EP3773591A4 (enExample) |
| JP (1) | JP2021524835A (enExample) |
| KR (1) | KR20210003780A (enExample) |
| CN (1) | CN112533602A (enExample) |
| AU (1) | AU2019247498A1 (enExample) |
| BR (1) | BR112020020246A8 (enExample) |
| CA (1) | CA3096984A1 (enExample) |
| IL (1) | IL277600A (enExample) |
| MX (1) | MX2020010437A (enExample) |
| PH (1) | PH12020551853A1 (enExample) |
| SG (1) | SG11202009443RA (enExample) |
| WO (1) | WO2019195753A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT2970205T (pt) | 2013-03-14 | 2019-08-26 | Tolero Pharmaceuticals Inc | Inibidores da jak2 e da alk2 e métodos para a sua utilização |
| BR112020020246A8 (pt) | 2018-04-05 | 2022-10-18 | Sumitomo Dainippon Pharma Oncology Inc | Inibidores de cinase axl e uso dos mesmos |
| KR20210038906A (ko) | 2018-07-26 | 2021-04-08 | 스미토모 다이니폰 파마 온콜로지, 인크. | 비정상적 acvr1 발현과 연관된 질환을 치료하는 방법 및 그에 사용하기 위한 acvr1 억제제 |
| MY204234A (en) | 2018-08-27 | 2024-08-16 | Regeneron Pharma | Use of raman spectroscopy in downstream purification |
| US20220380348A1 (en) * | 2019-10-04 | 2022-12-01 | Sumitomo Dainippon Pharma Oncology, Inc. | Axl inhibitor formulations |
| CN115989219B (zh) * | 2020-06-29 | 2026-02-13 | 贝凯恩生物医疗技术有限公司 | 用于治疗炎症小体介导的肺部疾病的丙磺舒化合物 |
| AU2021312139A1 (en) * | 2020-07-19 | 2023-03-02 | Aravive Inc. | Diagnostic methods for cancer using AXL decoy receptors |
| CN118574621A (zh) * | 2021-10-06 | 2024-08-30 | 美商纳维尔制药有限公司 | 取代的嘧啶-4(3h)-酮用于治疗癌症 |
| WO2023134582A1 (zh) * | 2022-01-14 | 2023-07-20 | 上海立森印迹医药技术有限公司 | 一种嘧啶-2,4-二胺衍生物及其制备方法和用途 |
| US20260176232A1 (en) * | 2022-11-04 | 2026-06-25 | Bacainn Biotherapeutics, Ltd. | Probenecid compounds for the treatment of inflammasome-mediated dermatological conditions |
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2019
- 2019-04-05 BR BR112020020246A patent/BR112020020246A8/pt not_active IP Right Cessation
- 2019-04-05 KR KR1020207031834A patent/KR20210003780A/ko not_active Withdrawn
- 2019-04-05 CA CA3096984A patent/CA3096984A1/en active Pending
- 2019-04-05 AU AU2019247498A patent/AU2019247498A1/en not_active Abandoned
- 2019-04-05 SG SG11202009443RA patent/SG11202009443RA/en unknown
- 2019-04-05 JP JP2020523746A patent/JP2021524835A/ja active Pending
- 2019-04-05 WO PCT/US2019/026094 patent/WO2019195753A1/en not_active Ceased
- 2019-04-05 MX MX2020010437A patent/MX2020010437A/es unknown
- 2019-04-05 US US16/376,452 patent/US11013741B1/en not_active Expired - Fee Related
- 2019-04-05 CN CN201980033174.9A patent/CN112533602A/zh active Pending
- 2019-04-05 EP EP19780739.9A patent/EP3773591A4/en not_active Withdrawn
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| MX2020010437A (es) | 2021-01-29 |
| CN112533602A (zh) | 2021-03-19 |
| PH12020551853A1 (en) | 2021-07-19 |
| KR20210003780A (ko) | 2021-01-12 |
| US11400091B2 (en) | 2022-08-02 |
| US20210205304A1 (en) | 2021-07-08 |
| US20230165857A1 (en) | 2023-06-01 |
| JP2021524835A (ja) | 2021-09-16 |
| AU2019247498A1 (en) | 2020-11-26 |
| WO2019195753A1 (en) | 2019-10-10 |
| BR112020020246A2 (pt) | 2021-01-12 |
| EP3773591A4 (en) | 2021-12-22 |
| IL277600A (en) | 2020-11-30 |
| EP3773591A1 (en) | 2021-02-17 |
| BR112020020246A8 (pt) | 2022-10-18 |
| SG11202009443RA (en) | 2020-10-29 |
| US11013741B1 (en) | 2021-05-25 |
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