CA3090294C - Methods of preparing tecovirimat - Google Patents
Methods of preparing tecovirimat Download PDFInfo
- Publication number
- CA3090294C CA3090294C CA3090294A CA3090294A CA3090294C CA 3090294 C CA3090294 C CA 3090294C CA 3090294 A CA3090294 A CA 3090294A CA 3090294 A CA3090294 A CA 3090294A CA 3090294 C CA3090294 C CA 3090294C
- Authority
- CA
- Canada
- Prior art keywords
- compound
- trifluoromethyl
- formula
- ethenocycloprop
- octahydro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
- C07D207/50—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/58—[b]- or [c]-condensed
- C07D209/72—4,7-Endo-alkylene-iso-indoles
- C07D209/76—4,7-Endo-alkylene-iso-indoles with oxygen atoms in positions 1 and 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D225/00—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom
- C07D225/04—Heterocyclic compounds containing rings of more than seven members having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Pyrrole Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CA3183432A CA3183432A1 (en) | 2012-08-16 | 2013-08-14 | Methods of preparing tecovirimat |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261683905P | 2012-08-16 | 2012-08-16 | |
| US61/683,905 | 2012-08-16 | ||
| CA2882506A CA2882506C (en) | 2012-08-16 | 2013-08-14 | Methods of preparing tecovirimat |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2882506A Division CA2882506C (en) | 2012-08-16 | 2013-08-14 | Methods of preparing tecovirimat |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3183432A Division CA3183432A1 (en) | 2012-08-16 | 2013-08-14 | Methods of preparing tecovirimat |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA3090294A1 CA3090294A1 (en) | 2014-02-20 |
| CA3090294C true CA3090294C (en) | 2023-01-24 |
Family
ID=50101462
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3090294A Active CA3090294C (en) | 2012-08-16 | 2013-08-14 | Methods of preparing tecovirimat |
| CA2882506A Active CA2882506C (en) | 2012-08-16 | 2013-08-14 | Methods of preparing tecovirimat |
| CA3183432A Pending CA3183432A1 (en) | 2012-08-16 | 2013-08-14 | Methods of preparing tecovirimat |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2882506A Active CA2882506C (en) | 2012-08-16 | 2013-08-14 | Methods of preparing tecovirimat |
| CA3183432A Pending CA3183432A1 (en) | 2012-08-16 | 2013-08-14 | Methods of preparing tecovirimat |
Country Status (8)
| Country | Link |
|---|---|
| US (5) | US9546137B2 (https=) |
| EP (3) | EP3321253B1 (https=) |
| JP (3) | JP6188802B2 (https=) |
| CN (3) | CN107235890B (https=) |
| AU (4) | AU2013302764B2 (https=) |
| CA (3) | CA3090294C (https=) |
| IL (1) | IL236944A (https=) |
| WO (1) | WO2014028545A1 (https=) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108084080A (zh) * | 2018-01-22 | 2018-05-29 | 安徽金鼎医药股份有限公司 | 一种格列齐特中间体六氢环戊并[c]吡咯基-2-胺盐酸盐的制备方法 |
| CN116003309B (zh) * | 2022-08-12 | 2025-03-04 | 深圳微芯生物科技股份有限公司 | 一类酰肼类化合物、其制备方法及其应用 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6596771B2 (en) | 2001-01-12 | 2003-07-22 | Schering Corporation | Drugs for treating viral infections |
| US6433016B1 (en) | 2001-01-12 | 2002-08-13 | Vassil Stefanov Georgiev | Drugs for treating viral infections |
| US7737168B2 (en) * | 2003-06-20 | 2010-06-15 | Siga Technologies, Inc. | Compounds, compositions, and methods for treatment and prevention of orthopoxvirus infections and associated diseases |
| EP1638938B1 (en) * | 2003-06-20 | 2017-04-12 | Siga Technologies Inc. | Compounds, compositions and methods for treatment and prevention of orthopoxvirus infections and associated diseases |
| US8530509B2 (en) | 2003-06-20 | 2013-09-10 | Siga Technologies, Inc. | Compounds, compositions and methods for treatment and prevention of orthopoxvirus infections and associated diseases |
| US7687641B2 (en) | 2003-06-20 | 2010-03-30 | Siga Technologies, Inc. | Chemicals, compositions, and methods for treatment and prevention of orthopoxvirus infections and associated diseases |
| US8642577B2 (en) * | 2005-04-08 | 2014-02-04 | Chimerix, Inc. | Compounds, compositions and methods for the treatment of poxvirus infections |
| CN104758281A (zh) * | 2007-04-23 | 2015-07-08 | 西佳技术公司 | 用于治疗和预防正痘病毒感染和相关疾病的化合物、组合物和方法 |
| WO2009086303A2 (en) * | 2007-12-21 | 2009-07-09 | University Of Rochester | Method for altering the lifespan of eukaryotic organisms |
| JP6018041B2 (ja) * | 2010-03-23 | 2016-11-02 | シガ・テクノロジーズ・インコーポレーテッド | Ｓｔ−２４６の多形型および調製方法 |
| CN101912389A (zh) * | 2010-08-09 | 2010-12-15 | 中国人民解放军军事医学科学院微生物流行病研究所 | 含st-246的药物组合物及其制备方法与应用 |
-
2013
- 2013-08-14 CN CN201710307535.7A patent/CN107235890B/zh active Active
- 2013-08-14 WO PCT/US2013/054816 patent/WO2014028545A1/en not_active Ceased
- 2013-08-14 EP EP17203980.2A patent/EP3321253B1/en active Active
- 2013-08-14 CA CA3090294A patent/CA3090294C/en active Active
- 2013-08-14 CN CN202010101449.2A patent/CN111393354B/zh active Active
- 2013-08-14 CA CA2882506A patent/CA2882506C/en active Active
- 2013-08-14 US US14/420,728 patent/US9546137B2/en active Active
- 2013-08-14 AU AU2013302764A patent/AU2013302764B2/en active Active
- 2013-08-14 CN CN201380042923.7A patent/CN104540508B/zh active Active
- 2013-08-14 CA CA3183432A patent/CA3183432A1/en active Pending
- 2013-08-14 EP EP13830000.9A patent/EP2887938B1/en active Active
- 2013-08-14 JP JP2015527551A patent/JP6188802B2/ja active Active
- 2013-08-14 EP EP19219627.7A patent/EP3656763B1/en active Active
-
2015
- 2015-01-27 IL IL236944A patent/IL236944A/en active IP Right Grant
-
2016
- 2016-12-08 US US15/372,587 patent/US9862683B2/en active Active
-
2017
- 2017-08-01 JP JP2017148805A patent/JP6444460B2/ja active Active
- 2017-12-01 US US15/829,344 patent/US10029985B2/en active Active
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2018
- 2018-03-01 AU AU2018201499A patent/AU2018201499B2/en active Active
- 2018-06-21 US US16/014,307 patent/US10155723B2/en active Active
- 2018-10-17 JP JP2018195480A patent/JP6564514B2/ja active Active
- 2018-11-09 US US16/185,355 patent/US10662155B2/en active Active
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2020
- 2020-04-30 AU AU2020202894A patent/AU2020202894B2/en active Active
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2022
- 2022-04-29 AU AU2022202841A patent/AU2022202841B2/en active Active
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20201106 |
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| U00 | Fee paid |
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| U11 | Full renewal or maintenance fee paid |
Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL Effective date: 20240809 |
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| MPN | Maintenance fee for patent paid |
Free format text: FEE DESCRIPTION TEXT: MF (PATENT, 12TH ANNIV.) - STANDARD Year of fee payment: 12 |
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| U00 | Fee paid |
Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED Effective date: 20250808 |
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| U11 | Full renewal or maintenance fee paid |
Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL Effective date: 20250808 |