CA3084812A1 - Dpo4 polymerase variants with improved accuracy - Google Patents
Dpo4 polymerase variants with improved accuracy Download PDFInfo
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- CA3084812A1 CA3084812A1 CA3084812A CA3084812A CA3084812A1 CA 3084812 A1 CA3084812 A1 CA 3084812A1 CA 3084812 A CA3084812 A CA 3084812A CA 3084812 A CA3084812 A CA 3084812A CA 3084812 A1 CA3084812 A1 CA 3084812A1
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- polymerase
- amino acid
- polymerases
- mutation
- dna
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| EP3377648B1 (en) | 2015-11-16 | 2021-01-06 | Stratos Genomics, Inc. | Dp04 polymerase variants |
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| US11530392B2 (en) | 2017-12-11 | 2022-12-20 | Stratos Genomics, Inc. | DPO4 polymerase variants with improved accuracy |
| WO2020236526A1 (en) | 2019-05-23 | 2020-11-26 | Stratos Genomics, Inc. | Translocation control elements, reporter codes, and further means for translocation control for use in nanopore sequencing |
| CN114144520B (zh) * | 2019-06-26 | 2024-12-13 | 豪夫迈·罗氏有限公司 | 通过芳香族化合物增强核酸聚合 |
| CN120051575A (zh) | 2022-10-21 | 2025-05-27 | 豪夫迈·罗氏有限公司 | 对核酸样品中的经修饰的核碱基的检测 |
| WO2025082960A1 (en) | 2023-10-18 | 2025-04-24 | F. Hoffmann-La Roche Ag | Dpo4 polymerase variants with improved properties |
| WO2025132779A2 (en) | 2023-12-22 | 2025-06-26 | F. Hoffmann-La Roche Ag | Methods and compositions for nucleic acid library and template preparation for duplexed sequencing by expansion |
| WO2025132780A2 (en) | 2023-12-22 | 2025-06-26 | F. Hoffmann-La Roche Ag | Methods and compositions for nucleic acid library and template preparation for duplexed sequencing by expansion |
| WO2025149478A1 (en) | 2024-01-12 | 2025-07-17 | F. Hoffmann-La Roche Ag | Compositions of modified nucleoside triphosphates |
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| US5614617A (en) | 1990-07-27 | 1997-03-25 | Isis Pharmaceuticals, Inc. | Nuclease resistant, pyrimidine modified oligonucleotides that detect and modulate gene expression |
| US5432272A (en) | 1990-10-09 | 1995-07-11 | Benner; Steven A. | Method for incorporating into a DNA or RNA oligonucleotide using nucleotides bearing heterocyclic bases |
| JP3739785B2 (ja) | 1991-11-26 | 2006-01-25 | アイシス ファーマシューティカルズ，インコーポレイティド | 修飾されたピリミジンを含有するオリゴマーを使用する増強された三重らせんおよび二重らせんの成形 |
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| WO2005113760A2 (en) | 2004-05-20 | 2005-12-01 | The Government Of The United States Of America, Represented By The Secretary Of The Department Of Health And Human Services | Thermostable y-family polymerases and chimeras |
| CA2633524A1 (en) | 2005-12-22 | 2007-07-05 | Pacific Biosciences Of California, Inc. | Polymerases for nucleotide analogue incorporation |
| AU2007309504B2 (en) | 2006-10-23 | 2012-09-13 | Pacific Biosciences Of California, Inc. | Polymerase enzymes and reagents for enhanced nucleic acid sequencing |
| JP5745842B2 (ja) | 2007-06-19 | 2015-07-08 | ストラトス ゲノミクス インコーポレイテッド | 拡張によるハイスループット核酸配列決定 |
| US8999676B2 (en) | 2008-03-31 | 2015-04-07 | Pacific Biosciences Of California, Inc. | Recombinant polymerases for improved single molecule sequencing |
| US9850471B2 (en) * | 2012-05-16 | 2017-12-26 | Noxxon Pharma Ag | Enzymatic synthesis of L-nucleic acids |
| US11634741B2 (en) | 2013-11-20 | 2023-04-25 | Aptarion Biotech Ag | Synthesis of L-nucleic acids by means of an enzyme |
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| US10526588B2 (en) * | 2015-05-14 | 2020-01-07 | Roche Sequencing Solutions, Inc. | Polymerase variants and uses thereof |
| EP3377648B1 (en) * | 2015-11-16 | 2021-01-06 | Stratos Genomics, Inc. | Dp04 polymerase variants |
| CN106318924B (zh) | 2016-10-26 | 2018-10-16 | 江南大学 | 一种催化dna合成延伸能力提高的dna聚合酶 |
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| US11530392B2 (en) | 2017-12-11 | 2022-12-20 | Stratos Genomics, Inc. | DPO4 polymerase variants with improved accuracy |
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| US11530392B2 (en) | 2022-12-20 |
| AU2018383610B2 (en) | 2024-09-12 |
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