CA3070861A1 - Chimeric antigen receptors with enhanced nfkb signaling - Google Patents
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- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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US201762561815P | 2017-09-22 | 2017-09-22 | |
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US201862666381P | 2018-05-03 | 2018-05-03 | |
US62/666,385 | 2018-05-03 | ||
US62/666,381 | 2018-05-03 | ||
PCT/US2018/050417 WO2019060174A1 (en) | 2017-09-22 | 2018-09-11 | CHIMERIC ANTIGENIC RECEPTORS WITH ENHANCED NFKB SIGNALING |
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JP (1) | JP2021500859A (ja) |
AU (1) | AU2018335266A1 (ja) |
CA (1) | CA3070861A1 (ja) |
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CA3044593A1 (en) | 2016-11-22 | 2018-05-31 | TCR2 Therapeutics Inc. | Compositions and methods for tcr reprogramming using fusion proteins |
JP2021514631A (ja) * | 2018-02-26 | 2021-06-17 | フレッド ハッチンソン キャンサー リサーチ センター | 細胞免疫療法のための組成物および方法 |
SG11202111130SA (en) | 2019-04-30 | 2021-11-29 | Senti Biosciences Inc | Chimeric receptors and methods of use thereof |
SG10201908256RA (en) * | 2019-09-06 | 2021-04-29 | Nat Univ Singapore | T cell modified with a synthetic receptor containing a single ITAM signaling motif |
JP7439279B2 (ja) * | 2020-02-13 | 2024-02-27 | イミュノファーム テクノロジー カンパニー リミテッド | キメラ抗原受容体の最適化 |
CN115361968A (zh) * | 2020-03-31 | 2022-11-18 | 弗莱德哈钦森癌症中心 | 在抗原靶向免疫疗法中增加抗原阴性细胞死亡 |
CN111411085A (zh) * | 2020-04-10 | 2020-07-14 | 格源致善(上海)生物科技有限公司 | 一种嵌合抗原受体t细胞及其应用 |
WO2021244654A1 (en) * | 2020-06-05 | 2021-12-09 | Nanjing Legend Biotech Co., Ltd. | Activation induced cytokine production in immune cells |
US20240115608A1 (en) * | 2021-02-10 | 2024-04-11 | The Regents Of The University Of California | Immune receptors with synthetic co-stimulatory domains |
CN113203781B (zh) * | 2021-05-13 | 2022-05-31 | 桂林电子科技大学 | 一种非诊断目的基于RGO-CS-Hemin@Pt NPs纳米材料和适配体检测GPC3的方法 |
WO2023245042A2 (en) * | 2022-06-14 | 2023-12-21 | H. Lee Moffitt Cancer Center And Research Institute Inc. | Nkg2d expressing car-t cells |
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US20130266551A1 (en) * | 2003-11-05 | 2013-10-10 | St. Jude Children's Research Hospital, Inc. | Chimeric receptors with 4-1bb stimulatory signaling domain |
CN105142677B (zh) * | 2013-02-15 | 2019-08-30 | 加利福尼亚大学董事会 | 嵌合抗原受体及其使用方法 |
US11542488B2 (en) * | 2014-07-21 | 2023-01-03 | Novartis Ag | Sortase synthesized chimeric antigen receptors |
CN112410363A (zh) * | 2014-08-19 | 2021-02-26 | 诺华股份有限公司 | 抗cd123嵌合抗原受体(car)用于癌症治疗 |
EP3336107A1 (en) * | 2016-12-15 | 2018-06-20 | Miltenyi Biotec GmbH | Immune cells expressing an antigen binding receptor and a chimeric costimulatory receptor |
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AU2018335266A1 (en) | 2020-02-06 |
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WO2019060174A1 (en) | 2019-03-28 |
JP2021500859A (ja) | 2021-01-14 |
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