CA3069754A1 - Cancer detection and classification using methylome analysis - Google Patents

Cancer detection and classification using methylome analysis Download PDF

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Publication number
CA3069754A1
CA3069754A1 CA3069754A CA3069754A CA3069754A1 CA 3069754 A1 CA3069754 A1 CA 3069754A1 CA 3069754 A CA3069754 A CA 3069754A CA 3069754 A CA3069754 A CA 3069754A CA 3069754 A1 CA3069754 A1 CA 3069754A1
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Prior art keywords
dna
cell
cancer
free
methylated
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CA3069754A
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English (en)
French (fr)
Inventor
Daniel Diniz De Carvalho
Scott Victor BRATMAN
Rajat SINGHANIA
Ankur Ravinarayana Chakravarthy
Shu Yi Shen
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University Health Network
Sinai Health System
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University Health Network
Sinai Health System
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Publication of CA3069754A1 publication Critical patent/CA3069754A1/en
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
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    • C12Q1/6869—Methods for sequencing
    • G—PHYSICS
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    • G06F18/00—Pattern recognition
    • G06F18/20—Analysing
    • G06F18/24—Classification techniques
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    • G—PHYSICS
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    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/20—Allele or variant detection, e.g. single nucleotide polymorphism [SNP] detection
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    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • G—PHYSICS
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    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
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    • G16B40/00—ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G16B40/20—Supervised data analysis
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B5/00—ICT specially adapted for modelling or simulations in systems biology, e.g. gene-regulatory networks, protein interaction networks or metabolic networks
    • G16B5/20—Probabilistic models
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    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2522/00—Reaction characterised by the use of non-enzymatic proteins
    • C12Q2522/10—Nucleic acid binding proteins
    • C—CHEMISTRY; METALLURGY
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    • C12Q2537/00—Reactions characterised by the reaction format or use of a specific feature
    • C12Q2537/10—Reactions characterised by the reaction format or use of a specific feature the purpose or use of
    • C12Q2537/164—Methylation detection other then bisulfite or methylation sensitive restriction endonucleases
    • C—CHEMISTRY; METALLURGY
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • G16B30/20—Sequence assembly

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  • Life Sciences & Earth Sciences (AREA)
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CA3069754A 2017-07-12 2018-07-11 Cancer detection and classification using methylome analysis Pending CA3069754A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762531527P 2017-07-12 2017-07-12
US62/531,527 2017-07-12
PCT/CA2018/000141 WO2019010564A1 (en) 2017-07-12 2018-07-11 DETECTION AND CLASSIFICATION OF CANCER USING METHYLOME ANALYSIS

Publications (1)

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CA3069754A1 true CA3069754A1 (en) 2019-01-17

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CA3069754A Pending CA3069754A1 (en) 2017-07-12 2018-07-11 Cancer detection and classification using methylome analysis

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US (2) US12031184B2 (https=)
EP (1) EP3652741A4 (https=)
JP (2) JP2020537487A (https=)
KR (2) KR102628878B1 (https=)
CN (2) CN118600004A (https=)
BR (1) BR112020000681A2 (https=)
CA (1) CA3069754A1 (https=)
WO (1) WO2019010564A1 (https=)

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US12592321B2 (en) * 2020-06-19 2026-03-31 University Health Network Cancer detection and classification using methylome analysis
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KR102491322B1 (ko) * 2022-03-29 2023-01-27 주식회사 아이엠비디엑스 암 진단을 위한 다중 분석 예측 모델의 제조 방법
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CN115376616A (zh) * 2022-10-24 2022-11-22 臻和(北京)生物科技有限公司 一种基于cfDNA多组学的多分类方法及装置
CN115376616B (zh) * 2022-10-24 2023-04-28 臻和(北京)生物科技有限公司 一种基于cfDNA多组学的多分类方法及装置

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EP3652741A1 (en) 2020-05-20
KR102628878B1 (ko) 2024-01-23
US20200308651A1 (en) 2020-10-01
US20220251665A1 (en) 2022-08-11
CN118600004A (zh) 2024-09-06
JP2020537487A (ja) 2020-12-24
EP3652741A4 (en) 2021-04-21
WO2019010564A1 (en) 2019-01-17
JP2023139162A (ja) 2023-10-03
KR102930572B1 (ko) 2026-02-24
US12031184B2 (en) 2024-07-09
BR112020000681A2 (pt) 2020-07-14
KR20240018667A (ko) 2024-02-13
KR20200032127A (ko) 2020-03-25
CN111094590A (zh) 2020-05-01

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