CA3067068C - Methods of producing bioengineered neuronal organoids (benos) and uses thereof - Google Patents

Methods of producing bioengineered neuronal organoids (benos) and uses thereof Download PDF

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CA3067068C
CA3067068C CA3067068A CA3067068A CA3067068C CA 3067068 C CA3067068 C CA 3067068C CA 3067068 A CA3067068 A CA 3067068A CA 3067068 A CA3067068 A CA 3067068A CA 3067068 C CA3067068 C CA 3067068C
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day
cells
matrix
neuronal
beno
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CA3067068A1 (en
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Wolfram-Hubertus Zimmermann
Maria Patapia ZAFEIRIOU
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Universitaetsmedizin Goettingen Georg August Universitaet
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Universitaetsmedizin Goettingen Georg August Universitaet
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
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CA3067068A 2017-06-13 2018-06-08 Methods of producing bioengineered neuronal organoids (benos) and uses thereof Active CA3067068C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP17175874 2017-06-13
EP17175874.1 2017-06-13
EP17205951.1 2017-12-07
EP17205951.1A EP3415618B1 (en) 2017-06-13 2017-12-07 Methods of producing bioengineered neuronal organoids (benos) and uses thereof
PCT/EP2018/065204 WO2018228948A1 (en) 2017-06-13 2018-06-08 Methods of producing bioengineered neuronal organoids (benos) and uses thereof

Publications (2)

Publication Number Publication Date
CA3067068A1 CA3067068A1 (en) 2018-12-20
CA3067068C true CA3067068C (en) 2023-05-23

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CA3067068A Active CA3067068C (en) 2017-06-13 2018-06-08 Methods of producing bioengineered neuronal organoids (benos) and uses thereof

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US (2) US11781109B2 (https=)
EP (1) EP3415618B1 (https=)
JP (1) JP7340252B2 (https=)
KR (1) KR102590084B1 (https=)
CN (1) CN110741078B (https=)
AU (1) AU2018283364B2 (https=)
CA (1) CA3067068C (https=)
DK (1) DK3415618T3 (https=)
ES (1) ES2903187T3 (https=)
WO (1) WO2018228948A1 (https=)

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CN108456659B (zh) 2018-03-14 2020-05-05 浙江霍德生物工程有限公司 3d大脑类器官的制备方法
WO2020165059A1 (en) * 2019-02-11 2020-08-20 Miltenyi Biotec B.V. & Co. KG Generation of human pluripotent stem cell derived artificial tissue structures without three dimensional matrices
US20220233602A1 (en) * 2019-07-05 2022-07-28 Novo Nordisk A/S Generation of neural stem cell lines derived from human pluripotent stem cells
CN112481212A (zh) * 2020-11-27 2021-03-12 杭州联众医疗科技股份有限公司 一种利用多能干细胞生成脑部类器官的方法
KR102638839B1 (ko) * 2021-04-06 2024-02-23 충북대학교 산학협력단 돼지 신경 오가노이드 제조방법
WO2022256643A1 (en) * 2021-06-04 2022-12-08 The Trustees Of The University Of Pennsylvania Tissue-engineered rostral migratory stream for neuronal replacement
CN115404218B (zh) * 2022-01-13 2024-09-24 南华大学附属第一医院 一种包含胶质细胞的3d人脑类器官培养方法
EP4386384A1 (en) 2022-12-15 2024-06-19 Georg-August-Universität Göttingen Stiftung Öffentlichen Rechts, Universitätsmedizin Potency assay for pharmaceutical products
CN116159182B (zh) * 2023-02-02 2024-09-24 中国科学院苏州纳米技术与纳米仿生研究所 用于治疗脊髓损伤的神经类器官-水凝胶体系及制备方法
CN118272307A (zh) * 2024-04-23 2024-07-02 妙顺（上海）生物科技有限公司 一种神经类器官三维培养诱导分化的方法及其应用
EP4678739A1 (en) * 2024-07-10 2026-01-14 Fundación Pública Andaluza Progreso Y Salud In vitro method for obtaining cortical brain organoids, cortical brain organoids and uses thereof

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JP2016521971A (ja) * 2013-04-23 2016-07-28 イェダ リサーチ アンド ディベロップメント カンパニー リミテッド 単離ナイーブ型多能性幹細胞およびそれを発生させる方法関連出願本出願は、米国特許法１１９条第（ｅ）項に基づき、２０１４年１月２９日出願の米国特許仮出願第６１／９３２，９３５号、２０１３年９月１７日出願の米国特許仮出願第６１／８７８，７６９号、および２０１３年４月２３日出願の米国特許仮出願第６１／８１４，９２０号の優先権を主張する。また、本出願は、同時に提出された同出願人による同時係属出願である、ＹａｑｕｂＨＡＮＮＡ、ＮｏａＮＯＶＥＲＳＨＴＥＲＮ、およびＹｏａｃｈＲＡＩＳによる米国特許出願（発明の名称「単離ナイーブ型多能性幹細胞およびそれを発生させる方法（ＩＳＯＬＡＴＥＤＮＡＩＶＥＰＬＵＲＩＰＯＴＥＮＴＳＴＥＭＣＥＬＬＳＡＮＤＭＥＴＨＯＤＳＯＦＧＥＮＥＲＡＴＩＮＧＳＡＭＥ）」）（代理人事件記録簿第５８８７０号）にも関する。上記出願の内容はその全体を参考として本明細書に組み込む。
AU2015261380B2 (en) * 2014-05-16 2021-04-15 Koninklijke Nederlandse Akademie Van Wetenschappen Improved culture method for organoids
WO2016028880A1 (en) * 2014-08-19 2016-02-25 Cellular Dynamics International, Inc. Neural networks formed from cells derived from pluripotent stem cells
LU92845B1 (en) * 2015-10-08 2017-05-02 Univ Du Luxembourg Campus Belval Means and methods for generating midbrain organoids
WO2017117547A1 (en) * 2015-12-31 2017-07-06 President And Fellows Of Harvard College Methods for generating neural tissue and uses thereof
EP3190176A1 (en) * 2016-01-11 2017-07-12 IMBA-Institut für Molekulare Biotechnologie GmbH Method for tissue culture development on scaffold and differentiated tissue culture

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