CA3066689C - Treatment of inflammatory diseases with inhibitors of c5a activity - Google Patents
Treatment of inflammatory diseases with inhibitors of c5a activity Download PDFInfo
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- CA3066689C CA3066689C CA3066689A CA3066689A CA3066689C CA 3066689 C CA3066689 C CA 3066689C CA 3066689 A CA3066689 A CA 3066689A CA 3066689 A CA3066689 A CA 3066689A CA 3066689 C CA3066689 C CA 3066689C
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- A61P17/00—Drugs for dermatological disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
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- Chemical Kinetics & Catalysis (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Compounds Of Unknown Constitution (AREA)
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| EP17177657.8 | 2017-06-23 | ||
| EP17177657 | 2017-06-23 | ||
| EP17189938 | 2017-09-07 | ||
| EP17189938.8 | 2017-09-07 | ||
| PCT/EP2018/065676 WO2018234118A1 (en) | 2017-06-23 | 2018-06-13 | Treatment of inflammatory diseases with inhibitors of c5a activity |
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| CA3066689A1 CA3066689A1 (en) | 2018-12-27 |
| CA3066689C true CA3066689C (en) | 2024-01-16 |
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| MY191668A (en) | 2016-06-14 | 2022-07-06 | Regeneron Pharma | Anti-c5 antibodies and uses thereof |
| JP2021506241A (ja) | 2017-12-13 | 2021-02-22 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | 抗ｃ５抗体組み合わせ物およびその使用 |
| JP7617012B2 (ja) | 2019-03-14 | 2025-01-17 | モルフォシス・アーゲー | Ｃ５ａＲを標的とする抗体 |
| TWI869528B (zh) | 2020-01-13 | 2025-01-11 | 美商威特拉公司 | C5ar1抗體分子及其用途 |
| AU2020438234A1 (en) * | 2020-03-27 | 2022-09-29 | Inflarx Gmbh | Inhibitors of C5a for the treatment of corona virus infection |
| EP4172200A4 (en) * | 2020-06-24 | 2024-10-30 | Staidson (Beijing) Biopharmaceuticals Co., Ltd. | ANTIBODIES SPECIFICALLY RECOGNIZING C5A AND THEIR USES |
| AU2022207985A1 (en) | 2021-01-13 | 2023-07-06 | Visterra, Inc. | Humanized complement 5a receptor 1 antibodies and methods of use thereof |
| US12180274B2 (en) | 2023-05-26 | 2024-12-31 | Inflarx Gmbh | Treatment of pneumonia and ARDS with inhibitors of C5a and IL-6 activity |
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| US4704355A (en) | 1985-03-27 | 1987-11-03 | New Horizons Diagnostics Corporation | Assay utilizing ATP encapsulated within liposome particles |
| WO1991004014A1 (en) | 1989-09-21 | 1991-04-04 | Synergen, Inc. | Method for transporting compositions across the blood brain barrier |
| DE69133566T2 (de) | 1990-01-12 | 2007-12-06 | Amgen Fremont Inc. | Bildung von xenogenen Antikörpern |
| AUPO755097A0 (en) | 1997-06-25 | 1997-07-17 | University Of Queensland, The | Receptor agonist and antagonist |
| US7754208B2 (en) | 2001-01-17 | 2010-07-13 | Trubion Pharmaceuticals, Inc. | Binding domain-immunoglobulin fusion proteins |
| US20030133939A1 (en) | 2001-01-17 | 2003-07-17 | Genecraft, Inc. | Binding domain-immunoglobulin fusion proteins |
| AUPR833401A0 (en) | 2001-10-17 | 2001-11-08 | University Of Queensland, The | G protein-coupled receptor antagonists |
| PL3385384T3 (pl) | 2004-02-12 | 2021-03-08 | Archemix Llc | Aptamerowe środki terapeutyczne użyteczne w leczeniu zaburzeń powiązanych z dopełniaczem |
| WO2005092366A1 (en) * | 2004-03-26 | 2005-10-06 | Promics Pty Limited | TREATMENT OF NEUROLOGICAL CONDITIONS USING COMPLEMENT C5a RECEPTOR MODULATORS |
| US20110301098A1 (en) | 2006-07-21 | 2011-12-08 | Quax Paul H A | Treatment for intimal hyperplasia and related conditions |
| GB0617734D0 (en) | 2006-09-08 | 2006-10-18 | Evolutec Ltd | Method of treating peripheral nerve disorders |
| ES2577548T3 (es) | 2008-12-22 | 2016-07-15 | Chemocentryx, Inc. | Antagonistas de C5aR |
| GB0905790D0 (en) | 2009-04-03 | 2009-05-20 | Alligator Bioscience Ab | Novel polypeptides and use thereof |
| EP2327725A1 (en) | 2009-11-26 | 2011-06-01 | InflaRx GmbH | Anti-C5a binding moieties with high blocking activity |
| US9126939B2 (en) | 2010-06-24 | 2015-09-08 | Pingchen Fan | C5AR antagonists |
| PL2970974T3 (pl) | 2013-03-14 | 2018-01-31 | Alnylam Pharmaceuticals Inc | Kompozycje komponentu C5 dopełniacza iRNA i sposoby ich zastosowania |
| DK2994488T3 (da) * | 2013-05-08 | 2022-10-03 | Novo Nordisk As | Anvendelse af c5ar-antagonister |
| EP3119802B1 (en) | 2014-03-20 | 2019-12-04 | InflaRx GmbH | Inhibitors of c5a for the treatment of viral pneumonia |
| EP3194596A1 (en) | 2014-09-16 | 2017-07-26 | Alnylam Pharmaceuticals, Inc. | Complement component c5 irna compositions and methods of use thereof |
| JP6479974B2 (ja) | 2014-10-15 | 2019-03-06 | アレクシオン ファーマシューティカルズ， インコーポレイテッド | 大規模エクリズマブ産生細胞培養を再現する方法 |
| FR3030515B1 (fr) * | 2014-12-23 | 2017-01-20 | Galderma Res & Dev | Nouveaux composes antagonistes des recepteurs cxcr1 et cxcr2 aux chimiokines, et leur utilisation dans le traitement de pathologies mediees par des chimiokines |
| US20180142010A1 (en) | 2015-06-26 | 2018-05-24 | Alexion Pharmaceuticals, Inc. | Method for treating a patient in compliance with vaccination with eculizumab or an eculizumab variant |
| NZ747259A (en) | 2016-04-04 | 2022-11-25 | Chemocentryx Inc | Soluble c5ar antagonists |
| PL3411400T3 (pl) | 2017-04-03 | 2021-12-20 | Inflarx Gmbh | Leczenie chorób zapalnych za pomocą inhibitorów aktywności c5a |
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- 2018-06-13 SG SG11201912882QA patent/SG11201912882QA/en unknown
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2019
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| CA3066689A1 (en) | 2018-12-27 |
| TWI786132B (zh) | 2022-12-11 |
| TW201904611A (zh) | 2019-02-01 |
| EP3642230A1 (en) | 2020-04-29 |
| AU2018286754A1 (en) | 2019-12-19 |
| IL271074A (en) | 2020-01-30 |
| CN111201241A (zh) | 2020-05-26 |
| JP2020524696A (ja) | 2020-08-20 |
| KR20200020727A (ko) | 2020-02-26 |
| JP7502865B2 (ja) | 2024-06-19 |
| WO2018234118A1 (en) | 2018-12-27 |
| SG11201912882QA (en) | 2020-01-30 |
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