CA3065086A1 - High affinity cxcr4 selective binding conjugate and method for using the same - Google Patents
High affinity cxcr4 selective binding conjugate and method for using the same Download PDFInfo
- Publication number
- CA3065086A1 CA3065086A1 CA3065086A CA3065086A CA3065086A1 CA 3065086 A1 CA3065086 A1 CA 3065086A1 CA 3065086 A CA3065086 A CA 3065086A CA 3065086 A CA3065086 A CA 3065086A CA 3065086 A1 CA3065086 A1 CA 3065086A1
- Authority
- CA
- Canada
- Prior art keywords
- ipr
- high affinity
- selective binding
- binding ligand
- peptide conjugate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Classifications
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- C07K7/04—Linear peptides containing only normal peptide links
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- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
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- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
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- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7158—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for chemokines
Landscapes
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- Chemical Kinetics & Catalysis (AREA)
- Toxicology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
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| US201762554354P | 2017-09-05 | 2017-09-05 | |
| US62/554,354 | 2017-09-05 | ||
| PCT/US2018/018530 WO2019050564A1 (en) | 2017-09-05 | 2018-02-17 | CXCR4 SELECTIVE BINDING CONJUGATE WITH HIGH AFFINITY AND METHOD OF USING THE SAME |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3065086A1 true CA3065086A1 (en) | 2019-03-14 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3065086A Pending CA3065086A1 (en) | 2017-09-05 | 2018-02-17 | High affinity cxcr4 selective binding conjugate and method for using the same |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP3679053A4 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2020532496A (cg-RX-API-DMAC7.html) |
| KR (2) | KR20200043970A (cg-RX-API-DMAC7.html) |
| CN (1) | CN111183146A (cg-RX-API-DMAC7.html) |
| CA (1) | CA3065086A1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2019050564A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11123437B2 (en) | 2017-09-05 | 2021-09-21 | Mainline Biosciences, Inc. | Selective CXCR4 binding peptide conjugate and methods for making and using the same |
| JP2021165234A (ja) * | 2018-07-03 | 2021-10-14 | 富士フイルム富山化学株式会社 | Ｃｘｃｒ４結合性化合物もしくはその塩またはそれらと金属との錯体 |
| US20220218852A1 (en) * | 2019-04-18 | 2022-07-14 | Provincial Health Services Authority | Novel radiolabelled cxcr4-targeting compounds for diagnosis and therapy |
| WO2021150258A1 (en) * | 2020-01-26 | 2021-07-29 | Mainline Biosciences Llc | Isotopically labelled selective cxcr4 binding peptide conjugate and methods for making and using the same |
| JP2024518287A (ja) | 2022-02-11 | 2024-05-01 | シーバイオメックス カンパニー リミテッド | 炭酸脱水素酵素ｉｘを標的にするペプチドリガンド、これを含むペプチド構造体及びその用途 |
| CN114832113B (zh) * | 2022-03-22 | 2023-06-20 | 重庆医科大学 | 疏水药物-马来酰亚胺衍生物及其主动载药脂质体和应用 |
| CA3249424A1 (en) * | 2022-04-20 | 2023-10-26 | Alpha-9 Oncology Inc. | Compounds targeting CXCR4, and their manufacturing and use processes |
| CN116023438B (zh) * | 2023-02-06 | 2025-07-11 | 中国药科大学 | 一种cxcr4靶向多肽及其应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US8628750B2 (en) * | 2006-02-27 | 2014-01-14 | Technische Universitat Munchen | Cancer imaging and treatment |
| BRPI0812134A2 (pt) * | 2007-05-30 | 2014-11-18 | Lilly Co Eli | Anatagonistas de cxcr4 de peptídio cíclico |
| IT1397901B1 (it) * | 2010-01-26 | 2013-02-04 | Consiglio Nazionale Ricerche | Peptidi ciclici che legano il recettore cxcr4 e relativi usi in campo medico e diagnostico. |
| CN102626522B (zh) * | 2012-04-12 | 2014-09-10 | 韩彦江 | 基于趋化因子受体cxcr4多肽类拮抗剂的多肽放射性诊断与治疗药物 |
| MX355396B (es) * | 2012-06-06 | 2018-04-18 | Polyphor Ag | Peptido - mimeticos de la horquilla beta. |
| US9790286B2 (en) * | 2013-01-02 | 2017-10-17 | Lucia Irene Gonzalez | Stereoisomer peptides, their polymer conjugates, their encapsulation into nanoparticles, and uses thereof for the treatment of diseases caused by abnormal angiogenesis |
| PL3152226T3 (pl) * | 2014-06-06 | 2019-10-31 | Univ Muenchen Tech | Modyfikowane cyklopentapeptydy i ich zastosowania |
-
2018
- 2018-02-17 EP EP18852912.7A patent/EP3679053A4/en not_active Withdrawn
- 2018-02-17 JP JP2020504380A patent/JP2020532496A/ja active Pending
- 2018-02-17 CA CA3065086A patent/CA3065086A1/en active Pending
- 2018-02-17 KR KR1020207000227A patent/KR20200043970A/ko not_active Ceased
- 2018-02-17 KR KR1020237034343A patent/KR20230145543A/ko not_active Ceased
- 2018-02-17 CN CN201880049498.7A patent/CN111183146A/zh active Pending
- 2018-02-17 WO PCT/US2018/018530 patent/WO2019050564A1/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| KR20230145543A (ko) | 2023-10-17 |
| JP2020532496A (ja) | 2020-11-12 |
| KR20200043970A (ko) | 2020-04-28 |
| WO2019050564A1 (en) | 2019-03-14 |
| EP3679053A1 (en) | 2020-07-15 |
| CN111183146A (zh) | 2020-05-19 |
| EP3679053A4 (en) | 2021-10-27 |
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