CA3062978A1 - Macrophages transgeniques, recepteurs d'antigenes chimeriques et methodes associees - Google Patents
Macrophages transgeniques, recepteurs d'antigenes chimeriques et methodes associees Download PDFInfo
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Landscapes
- Health & Medical Sciences (AREA)
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Abstract
L'invention concerne des récepteurs chimériques. Les récepteurs chimériques comprennent un domaine cytoplasmique ; un domaine transmembranaire ; et un domaine extracellulaire. Dans des modes de réalisation, le domaine cytoplasmique comprend une partie cyptoplasmique d'un récepteur qui, lorsqu'elle est activée, polarise un macrophage. Dans d'autres modes de réalisation, une protéine de type sauvage comprenant la partie cytoplasmique ne comprend pas le domaine extracellulaire du récepteur chimérique. Dans des modes de réalisation, la liaison d'un ligand au domaine extracellulaire du récepteur chimérique active la partie intracellulaire du récepteur chimérique. L'activation de la partie intracellulaire du récepteur chimérique peut polariser le macrophage en un macrophage M1 ou M2.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US2017/033039 WO2018212770A1 (fr) | 2017-05-17 | 2017-05-17 | Macrophages transgéniques, récepteurs d'antigènes chimériques et méthodes associées |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3062978A1 true CA3062978A1 (fr) | 2018-11-22 |
Family
ID=59078161
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3062978A Pending CA3062978A1 (fr) | 2017-05-17 | 2017-05-17 | Macrophages transgeniques, recepteurs d'antigenes chimeriques et methodes associees |
Country Status (8)
| Country | Link |
|---|---|
| EP (1) | EP3624834A1 (fr) |
| JP (2) | JP7164598B2 (fr) |
| KR (1) | KR102508182B1 (fr) |
| CN (1) | CN110662553A (fr) |
| AU (1) | AU2017414703A1 (fr) |
| CA (1) | CA3062978A1 (fr) |
| WO (1) | WO2018212770A1 (fr) |
| ZA (1) | ZA201908245B (fr) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10434153B1 (en) | 2015-05-20 | 2019-10-08 | Kim Leslie O'Neill | Use of car and bite technology coupled with an scFv from an antibody against human thymidine kinase 1 to specifically target tumors |
| US11352439B2 (en) | 2015-08-13 | 2022-06-07 | Kim Leslie O'Neill | Macrophage CAR (MOTO-CAR) in immunotherapy |
| CN110036033B (zh) | 2016-09-27 | 2023-12-08 | 森罗治疗公司 | 嵌合吞噬受体分子 |
| CN109336980B (zh) * | 2017-07-27 | 2022-04-12 | 上海细胞治疗研究院 | 一种靶向Muc1的嵌合抗原受体修饰T细胞及其用途 |
| KR20200100598A (ko) | 2017-09-26 | 2020-08-26 | 세로 테라퓨틱스, 인코포레이티드 | 키메라 포식작용 수용체 분자 및 사용 방법 |
| US20220332780A1 (en) | 2019-09-10 | 2022-10-20 | Obsidian Therapeutics, Inc. | Ca2-il15 fusion proteins for tunable regulation |
| CN113980138B (zh) * | 2021-08-11 | 2023-08-11 | 卡瑞济(北京)生命科技有限公司 | EphA2嵌合抗原受体以及其用途 |
Family Cites Families (6)
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|---|---|---|---|---|
| FR2422956A1 (fr) | 1978-04-13 | 1979-11-09 | Pasteur Institut | Procede de detection et de caracterisation d'un acide nucleique ou d'une sequence de celui-ci, et reactif enzymatique pour la mise en oeuvre de ce procede |
| FR2464269B1 (fr) | 1979-08-30 | 1986-04-18 | Anvar | Sequence nucleotidique codant l'antigene de surface du virus de l'hepatite b, procede permettant son obtention et antigene obtenu |
| FR2518755B1 (fr) | 1981-12-23 | 1986-04-11 | Pasteur Institut | Sonde contenant un acide nucleique modifie et reconnaissable par des anticorps specifiques et utilisation de cette sonde pour detecter et caracteriser une sequence d'adn homologue |
| CA3225453A1 (fr) | 2013-12-19 | 2015-06-25 | Novartis Ag | Recepteurs antigeniques chimeriques de la mesotheline humaine et leurs utilisations |
| MX2018001182A (es) | 2015-07-28 | 2018-04-20 | Univ Pennsylvania | Monocitos/macrofagos modificados que expresan receptores de antigeno quimerico y sus usos. |
| KR20180054600A (ko) * | 2015-10-13 | 2018-05-24 | 브라이엄 영 유니버시티 | 면역치료에서의 대식세포 키메라 항원 수용체(moto-car) |
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2017
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- 2017-05-17 CA CA3062978A patent/CA3062978A1/fr active Pending
- 2017-05-17 EP EP17731332.7A patent/EP3624834A1/fr active Pending
- 2017-05-17 WO PCT/US2017/033039 patent/WO2018212770A1/fr unknown
- 2017-05-17 KR KR1020197037141A patent/KR102508182B1/ko active IP Right Grant
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| KR102508182B1 (ko) | 2023-03-09 |
| WO2018212770A1 (fr) | 2018-11-22 |
| JP7164598B2 (ja) | 2022-11-01 |
| AU2017414703A1 (en) | 2020-01-16 |
| EP3624834A1 (fr) | 2020-03-25 |
| JP2022189893A (ja) | 2022-12-22 |
| KR20200020708A (ko) | 2020-02-26 |
| JP2020520252A (ja) | 2020-07-09 |
| CN110662553A (zh) | 2020-01-07 |
| ZA201908245B (en) | 2020-12-23 |
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