CA3057751A1 - Electrosurgical instrument for ablation and resection - Google Patents
Electrosurgical instrument for ablation and resection Download PDFInfo
- Publication number
- CA3057751A1 CA3057751A1 CA3057751A CA3057751A CA3057751A1 CA 3057751 A1 CA3057751 A1 CA 3057751A1 CA 3057751 A CA3057751 A CA 3057751A CA 3057751 A CA3057751 A CA 3057751A CA 3057751 A1 CA3057751 A1 CA 3057751A1
- Authority
- CA
- Canada
- Prior art keywords
- energy
- transmission line
- conductive layer
- conveying
- tip
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000002271 resection Methods 0.000 title claims abstract description 25
- 238000002679 ablation Methods 0.000 title claims abstract description 17
- 230000005540 biological transmission Effects 0.000 claims abstract description 55
- 239000004020 conductor Substances 0.000 claims abstract description 30
- 239000012530 fluid Substances 0.000 claims description 19
- 238000003780 insertion Methods 0.000 claims description 4
- 230000037431 insertion Effects 0.000 claims description 4
- 238000000926 separation method Methods 0.000 claims description 4
- 239000000919 ceramic Substances 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 description 22
- 239000003989 dielectric material Substances 0.000 description 16
- 210000004027 cell Anatomy 0.000 description 6
- 239000000463 material Substances 0.000 description 4
- 230000000740 bleeding effect Effects 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 238000005345 coagulation Methods 0.000 description 3
- 230000015271 coagulation Effects 0.000 description 3
- 239000011248 coating agent Substances 0.000 description 3
- 238000000576 coating method Methods 0.000 description 3
- 239000002184 metal Substances 0.000 description 3
- 229910052751 metal Inorganic materials 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- 102000008186 Collagen Human genes 0.000 description 2
- 108010035532 Collagen Proteins 0.000 description 2
- 239000003990 capacitor Substances 0.000 description 2
- 229910010293 ceramic material Inorganic materials 0.000 description 2
- 229920001436 collagen Polymers 0.000 description 2
- 230000005684 electric field Effects 0.000 description 2
- 239000011159 matrix material Substances 0.000 description 2
- 239000004810 polytetrafluoroethylene Substances 0.000 description 2
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 206010053567 Coagulopathies Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 239000004642 Polyimide Substances 0.000 description 1
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 229940030225 antihemorrhagics Drugs 0.000 description 1
- 210000002565 arteriole Anatomy 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 210000000170 cell membrane Anatomy 0.000 description 1
- 210000002421 cell wall Anatomy 0.000 description 1
- 230000035602 clotting Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000006260 foam Substances 0.000 description 1
- 230000000025 haemostatic effect Effects 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 239000011810 insulating material Substances 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 239000007769 metal material Substances 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920001721 polyimide Polymers 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
- A61B18/14—Probes or electrodes therefor
- A61B18/1492—Probes or electrodes therefor having a flexible, catheter-like structure, e.g. for heart ablation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
- A61B18/1206—Generators therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/1815—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using microwaves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/042—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating using additional gas becoming plasma
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods
- A61B17/00234—Surgical instruments, devices or methods for minimally invasive surgery
- A61B2017/00292—Surgical instruments, devices or methods for minimally invasive surgery mounted on or guided by flexible, e.g. catheter-like, means
- A61B2017/003—Steerable
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00053—Mechanical features of the instrument of device
- A61B2018/00059—Material properties
- A61B2018/00071—Electrical conductivity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00053—Mechanical features of the instrument of device
- A61B2018/00059—Material properties
- A61B2018/00071—Electrical conductivity
- A61B2018/00077—Electrical conductivity high, i.e. electrically conducting
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00053—Mechanical features of the instrument of device
- A61B2018/00059—Material properties
- A61B2018/00071—Electrical conductivity
- A61B2018/00083—Electrical conductivity low, i.e. electrically insulating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00571—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for achieving a particular surgical effect
- A61B2018/00577—Ablation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00571—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for achieving a particular surgical effect
- A61B2018/00601—Cutting
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2018/00994—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body combining two or more different kinds of non-mechanical energy or combining one or more non-mechanical energies with ultrasound
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
- A61B18/14—Probes or electrodes therefor
- A61B2018/1405—Electrodes having a specific shape
- A61B2018/1417—Ball
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
- A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
- A61B18/14—Probes or electrodes therefor
- A61B18/16—Indifferent or passive electrodes for grounding
- A61B2018/162—Indifferent or passive electrodes for grounding located on the probe body
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/1815—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using microwaves
- A61B2018/1823—Generators therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
- A61B18/1815—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using microwaves
- A61B2018/1861—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves using microwaves with an instrument inserted into a body lumen or cavity, e.g. a catheter
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2218/00—Details of surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B2218/001—Details of surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body having means for irrigation and/or aspiration of substances to and/or from the surgical site
Landscapes
- Health & Medical Sciences (AREA)
- Surgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Medical Informatics (AREA)
- Otolaryngology (AREA)
- Veterinary Medicine (AREA)
- Physics & Mathematics (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Plasma & Fusion (AREA)
- Cardiology (AREA)
- Electromagnetism (AREA)
- Surgical Instruments (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1708726.3 | 2017-06-01 | ||
| GBGB1708726.3A GB201708726D0 (en) | 2017-06-01 | 2017-06-01 | Electrosurgical instrument for ablation and resection |
| PCT/EP2018/064466 WO2018220178A1 (en) | 2017-06-01 | 2018-06-01 | Electrosurgical instrument for ablation and resection |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3057751A1 true CA3057751A1 (en) | 2018-12-06 |
Family
ID=59349831
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3057751A Pending CA3057751A1 (en) | 2017-06-01 | 2018-06-01 | Electrosurgical instrument for ablation and resection |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US12108980B2 (enExample) |
| EP (2) | EP3777746B1 (enExample) |
| JP (2) | JP7304069B2 (enExample) |
| KR (1) | KR20200015886A (enExample) |
| CN (2) | CN110461264B (enExample) |
| AU (1) | AU2018278265A1 (enExample) |
| BR (1) | BR112019019820A2 (enExample) |
| CA (1) | CA3057751A1 (enExample) |
| ES (1) | ES3013083T3 (enExample) |
| GB (3) | GB201708726D0 (enExample) |
| SG (2) | SG11201908885UA (enExample) |
| WO (1) | WO2018220178A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU199430U1 (ru) * | 2020-02-06 | 2020-09-01 | Общество с ограниченной ответственностью фирма "ТЕХНОСВЕТ" | Универсальная установка для комплексного разрушения биоткани |
| JP7819188B2 (ja) * | 2020-10-27 | 2026-02-24 | ボストン サイエンティフィック メディカル デバイス リミテッド | 感知機能を有する電気外科手術装置 |
| GB202109754D0 (en) * | 2021-07-06 | 2021-08-18 | Creo Medical Ltd | A cable assembly for an electrosurgical instrument, and a method for manufacturing the same |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3490664T1 (de) * | 1984-03-07 | 1986-01-23 | Char'kovskaja oblastnaja kliničeskaja bol'nica, Char'kov | Bipolarer biaktiver Elektroagulator |
| EP0415997A4 (en) * | 1988-05-18 | 1992-04-08 | Kasevich Associates, Inc. | Microwave balloon angioplasty |
| US4945912A (en) * | 1988-11-25 | 1990-08-07 | Sensor Electronics, Inc. | Catheter with radiofrequency heating applicator |
| US20070066972A1 (en) * | 2001-11-29 | 2007-03-22 | Medwaves, Inc. | Ablation catheter apparatus with one or more electrodes |
| US6231571B1 (en) * | 1999-05-03 | 2001-05-15 | Alan G. Ellman | Electrosurgical handpiece for treating tissue |
| WO2003024349A1 (en) * | 2001-09-05 | 2003-03-27 | Tissuelink Medical, Inc. | Fluid-assisted medical devices, systems and methods |
| US6432105B1 (en) * | 2000-12-04 | 2002-08-13 | Alan G. Ellman | Bipolar electrosurgical handpiece for treating tissue |
| US20140039484A1 (en) * | 2003-09-19 | 2014-02-06 | Baylis Medical Company Inc. | Methods for creating a channel through an occlusion within a body vessel |
| US11234761B2 (en) * | 2006-01-27 | 2022-02-01 | Baylis Medical Company Inc. | Electrosurgical device for creating a channel through a region of tissue and methods of use thereof |
| US8317782B1 (en) * | 2006-10-13 | 2012-11-27 | Ellman International, Inc. | Non-ablative radio-frequency treatment of skin tissue |
| US8679106B2 (en) * | 2008-07-01 | 2014-03-25 | Medwaves, Inc. | Angioplasty and tissue ablation apparatus and method |
| US9173706B2 (en) * | 2008-08-25 | 2015-11-03 | Covidien Lp | Dual-band dipole microwave ablation antenna |
| DE112010004615B4 (de) * | 2009-11-30 | 2023-05-17 | Medwaves, Inc. | Radio frequenz ablation system mit tracking sensor |
| US20120150165A1 (en) * | 2010-12-10 | 2012-06-14 | Salient Surgical Technologies, Inc. | Bipolar Electrosurgical Device |
| GB2487199A (en) * | 2011-01-11 | 2012-07-18 | Creo Medical Ltd | Electrosurgical device with fluid conduit |
| US8974450B2 (en) * | 2011-02-03 | 2015-03-10 | Covidien Lp | System and method for ablation procedure monitoring using electrodes |
| WO2013005484A1 (ja) * | 2011-07-07 | 2013-01-10 | 山科精器株式会社 | 双極式針型マイクロ波手術器 |
| JP5769303B2 (ja) * | 2011-08-15 | 2015-08-26 | 日本ライフライン株式会社 | 電極カテーテル |
| US9775665B2 (en) * | 2013-03-15 | 2017-10-03 | Alan G Ellman | Fixed position RF electrode |
| GB201308558D0 (en) * | 2013-05-13 | 2013-06-19 | Creo Medical Ltd | Electrosurgical apparatus |
| US9814514B2 (en) * | 2013-09-13 | 2017-11-14 | Ethicon Llc | Electrosurgical (RF) medical instruments for cutting and coagulating tissue |
| KR200478381Y1 (ko) * | 2013-10-07 | 2015-09-25 | 김한호 | 조직 치료를 위한 일회용 전자 수술 핸드피스 |
| WO2015066311A1 (en) * | 2013-10-30 | 2015-05-07 | Thomas Jefferson University | Systems and methods for neuromodulation and treatment of abnormal growths |
| JP6108501B2 (ja) * | 2013-11-13 | 2017-04-05 | 国立大学法人滋賀医科大学 | マイクロ波照射器具 |
| GB2521611B (en) * | 2013-12-23 | 2020-02-12 | Creo Medical Ltd | Electrosurgical apparatus and electrosurgical device |
| EP3102132A4 (en) * | 2014-02-07 | 2017-11-01 | Verve Medical, Inc. | Methods and systems for ablation of the renal pelvis |
| GB201418479D0 (en) * | 2014-10-17 | 2014-12-03 | Creo Medical Ltd | Cable for conveying radiofrequency and/or microwave frequency energy to an electrosurgical instrument |
-
2017
- 2017-06-01 GB GBGB1708726.3A patent/GB201708726D0/en not_active Ceased
-
2018
- 2018-06-01 SG SG11201908885U patent/SG11201908885UA/en unknown
- 2018-06-01 ES ES20192321T patent/ES3013083T3/es active Active
- 2018-06-01 EP EP20192321.6A patent/EP3777746B1/en active Active
- 2018-06-01 CN CN201880022675.2A patent/CN110461264B/zh active Active
- 2018-06-01 KR KR1020197027506A patent/KR20200015886A/ko not_active Ceased
- 2018-06-01 CA CA3057751A patent/CA3057751A1/en active Pending
- 2018-06-01 JP JP2019556312A patent/JP7304069B2/ja active Active
- 2018-06-01 AU AU2018278265A patent/AU2018278265A1/en not_active Abandoned
- 2018-06-01 US US16/610,463 patent/US12108980B2/en active Active
- 2018-06-01 EP EP18729383.2A patent/EP3629969B1/en active Active
- 2018-06-01 SG SG10201913061TA patent/SG10201913061TA/en unknown
- 2018-06-01 BR BR112019019820A patent/BR112019019820A2/pt not_active IP Right Cessation
- 2018-06-01 WO PCT/EP2018/064466 patent/WO2018220178A1/en not_active Ceased
- 2018-06-01 GB GB1808994.6A patent/GB2564942B/en not_active Expired - Fee Related
- 2018-06-01 CN CN202310734838.2A patent/CN116549102A/zh active Pending
- 2018-06-01 GB GB1907729.6A patent/GB2571223B/en not_active Expired - Fee Related
-
2022
- 2022-06-06 JP JP2022091596A patent/JP7394482B2/ja active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP3777746C0 (en) | 2024-12-25 |
| SG10201913061TA (en) | 2020-03-30 |
| SG11201908885UA (en) | 2019-10-30 |
| JP2020521520A (ja) | 2020-07-27 |
| CN116549102A (zh) | 2023-08-08 |
| WO2018220178A1 (en) | 2018-12-06 |
| GB201907729D0 (en) | 2019-07-17 |
| AU2018278265A1 (en) | 2019-10-17 |
| JP2022119984A (ja) | 2022-08-17 |
| GB2564942A (en) | 2019-01-30 |
| EP3629969B1 (en) | 2026-05-06 |
| JP7394482B2 (ja) | 2023-12-08 |
| GB2571223B (en) | 2019-11-20 |
| EP3777746B1 (en) | 2024-12-25 |
| GB201808994D0 (en) | 2018-07-18 |
| KR20200015886A (ko) | 2020-02-13 |
| US12108980B2 (en) | 2024-10-08 |
| CN110461264B (zh) | 2023-10-31 |
| US20200289195A1 (en) | 2020-09-17 |
| GB2564942B (en) | 2020-03-18 |
| BR112019019820A2 (pt) | 2020-04-22 |
| ES3013083T3 (en) | 2025-04-10 |
| JP7304069B2 (ja) | 2023-07-06 |
| GB2571223A (en) | 2019-08-21 |
| EP3629969A1 (en) | 2020-04-08 |
| GB201708726D0 (en) | 2017-07-19 |
| CN110461264A (zh) | 2019-11-15 |
| EP3777746A1 (en) | 2021-02-17 |
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