CA3051262A1 - Engineered phenylalanine ammonia lyase polypeptides - Google Patents

Engineered phenylalanine ammonia lyase polypeptides Download PDF

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Publication number
CA3051262A1
CA3051262A1 CA3051262A CA3051262A CA3051262A1 CA 3051262 A1 CA3051262 A1 CA 3051262A1 CA 3051262 A CA3051262 A CA 3051262A CA 3051262 A CA3051262 A CA 3051262A CA 3051262 A1 CA3051262 A1 CA 3051262A1
Authority
CA
Canada
Prior art keywords
engineered
polypeptide
amino acid
composition
seq
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3051262A
Other languages
English (en)
French (fr)
Inventor
Chinping CHNG
William Casey Hallows
Nicholas J. Agard
Oscar Alvizo
Nikki DELLAS
Gjalt W. Huisman
John Joseph Nicols
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Codexis Inc
Original Assignee
Codexis Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Codexis Inc filed Critical Codexis Inc
Publication of CA3051262A1 publication Critical patent/CA3051262A1/en
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y403/00—Carbon-nitrogen lyases (4.3)
    • C12Y403/01—Ammonia-lyases (4.3.1)
    • C12Y403/01024—Phenylalanine ammonia-lyase (4.3.1.24)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Dermatology (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
CA3051262A 2017-02-13 2018-02-12 Engineered phenylalanine ammonia lyase polypeptides Pending CA3051262A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762458232P 2017-02-13 2017-02-13
US62/458,232 2017-02-13
US201762565555P 2017-09-29 2017-09-29
US62/565,555 2017-09-29
PCT/US2018/017773 WO2018148633A1 (en) 2017-02-13 2018-02-12 Engineered phenylalanine ammonia lyase polypeptides

Publications (1)

Publication Number Publication Date
CA3051262A1 true CA3051262A1 (en) 2018-08-16

Family

ID=63106144

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3051262A Pending CA3051262A1 (en) 2017-02-13 2018-02-12 Engineered phenylalanine ammonia lyase polypeptides

Country Status (15)

Country Link
US (4) US10995329B2 (https=)
EP (1) EP3579867A4 (https=)
JP (2) JP2020505942A (https=)
KR (1) KR102573324B1 (https=)
CN (1) CN110573175A (https=)
AU (1) AU2018217495B2 (https=)
BR (1) BR112019016634A2 (https=)
CA (1) CA3051262A1 (https=)
IL (1) IL268226A (https=)
MX (1) MX2019009615A (https=)
MY (1) MY196740A (https=)
NZ (1) NZ755628A (https=)
PH (1) PH12019501705A1 (https=)
SG (1) SG11201906880VA (https=)
WO (1) WO2018148633A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10900055B2 (en) 2018-06-12 2021-01-26 Codexis, Inc. Engineered tyrosine ammonia lyase
WO2021168060A1 (en) * 2020-02-19 2021-08-26 Trustees Of Tufts College Methods for engineering amino acid ammonia lyase enzymes and enzymes thereby obtained
CN112355034B (zh) * 2020-11-17 2021-08-06 同济大学 基于水热钙离子调配的有机固体废弃物无害化预处理方法
CN115518691B (zh) * 2022-10-14 2023-11-21 天津大学 一种具有类漆酶活性的人工酶及制备方法和应用
CN121586590A (zh) 2023-07-06 2026-02-27 佩尔西奥制药公司 包含工程改造的苯丙氨酸氨裂解酶(pal)的功能化组合物
KR20260036315A (ko) 2023-07-06 2026-03-16 페르세오 파마 아게 단백질 고정화 방법

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Also Published As

Publication number Publication date
MY196740A (en) 2023-05-03
US10995329B2 (en) 2021-05-04
BR112019016634A2 (pt) 2020-04-07
KR20190117577A (ko) 2019-10-16
AU2018217495B2 (en) 2021-03-04
US20180230448A1 (en) 2018-08-16
EP3579867A1 (en) 2019-12-18
WO2018148633A1 (en) 2018-08-16
US20230295599A1 (en) 2023-09-21
NZ755628A (en) 2023-09-29
AU2018217495A1 (en) 2019-08-08
KR102573324B1 (ko) 2023-08-30
EP3579867A4 (en) 2021-03-10
JP2020505942A (ja) 2020-02-27
IL268226A (en) 2019-09-26
JP2022103296A (ja) 2022-07-07
US20210222145A1 (en) 2021-07-22
MX2019009615A (es) 2019-10-14
SG11201906880VA (en) 2019-08-27
PH12019501705A1 (en) 2020-07-06
US20230295598A1 (en) 2023-09-21
CN110573175A (zh) 2019-12-13

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