CA3050332A1 - Treatment of trop-2 expressing triple negative breast cancer with sacituzumab govitecan and a rad51 inhibitor - Google Patents

Treatment of trop-2 expressing triple negative breast cancer with sacituzumab govitecan and a rad51 inhibitor Download PDF

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Publication number
CA3050332A1
CA3050332A1 CA3050332A CA3050332A CA3050332A1 CA 3050332 A1 CA3050332 A1 CA 3050332A1 CA 3050332 A CA3050332 A CA 3050332A CA 3050332 A CA3050332 A CA 3050332A CA 3050332 A1 CA3050332 A1 CA 3050332A1
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Prior art keywords
cancer
antibody
trop
adc
hrs7
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CA3050332A
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English (en)
French (fr)
Inventor
Thomas M. Cardillo
David M. Goldenberg
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Immunomedics Inc
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Immunomedics Inc
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Publication of CA3050332A1 publication Critical patent/CA3050332A1/en
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  • Medicinal Chemistry (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
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CA3050332A 2017-03-27 2018-03-20 Treatment of trop-2 expressing triple negative breast cancer with sacituzumab govitecan and a rad51 inhibitor Pending CA3050332A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762477216P 2017-03-27 2017-03-27
US62/477,216 2017-03-27
PCT/US2018/023344 WO2018183041A1 (en) 2017-03-27 2018-03-20 Treatment of trop-2 expressing triple negative breast cancer with sacituzumab govitecan and a rad51 inhibitor

Publications (1)

Publication Number Publication Date
CA3050332A1 true CA3050332A1 (en) 2018-10-04

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CA3050332A Pending CA3050332A1 (en) 2017-03-27 2018-03-20 Treatment of trop-2 expressing triple negative breast cancer with sacituzumab govitecan and a rad51 inhibitor

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US (1) US10918734B2 (https=)
EP (1) EP3600283A4 (https=)
JP (1) JP2020512314A (https=)
CN (1) CN110392570A (https=)
CA (1) CA3050332A1 (https=)
RU (1) RU2758234C2 (https=)
WO (1) WO2018183041A1 (https=)

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US20240139324A1 (en) * 2012-12-13 2024-05-02 Immunomedics, Inc. Dosages of immunoconjugates of antibodies and sn-38 for improved efficacy and decreased toxicity
US20210393617A1 (en) * 2012-12-13 2021-12-23 Immunomedics, Inc. Therapy for metastatic urothelial cancer with the antibody-drug conjugate, sacituzumab govitecan (immu-132)
WO2018192407A1 (zh) 2017-04-19 2018-10-25 四川科伦博泰生物医药股份有限公司 细胞毒素和偶联物、其用途和制备方法
CN119241554A (zh) 2017-12-15 2025-01-03 四川科伦博泰生物医药股份有限公司 生物活性物偶联物及其制备方法和用途
US12331320B2 (en) 2018-10-10 2025-06-17 The Research Foundation For The State University Of New York Genome edited cancer cell vaccines
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