CA3049393C - Umbilical cord lining stem cells and methods and material for isolating and culturing same - Google Patents

Umbilical cord lining stem cells and methods and material for isolating and culturing same Download PDF

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Publication number
CA3049393C
CA3049393C CA3049393A CA3049393A CA3049393C CA 3049393 C CA3049393 C CA 3049393C CA 3049393 A CA3049393 A CA 3049393A CA 3049393 A CA3049393 A CA 3049393A CA 3049393 C CA3049393 C CA 3049393C
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CA
Canada
Prior art keywords
cells
ulscs
purified population
growth factor
umbilical cord
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Active
Application number
CA3049393A
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English (en)
French (fr)
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CA3049393A1 (en
Inventor
Francisco J. Silva
Rafael Gonzalez
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Restem LLC
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Restem LLC
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Publication of CA3049393A1 publication Critical patent/CA3049393A1/en
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0603—Embryonic cells ; Embryoid bodies
    • C12N5/0605—Cells from extra-embryonic tissues, e.g. placenta, amnion, yolk sac, Wharton's jelly
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0607—Non-embryonic pluripotent stem cells, e.g. MASC
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00—Supports or coatings for cell culture, characterised by material
    • C12N2533/50—Proteins
    • C12N2533/52—Fibronectin; Laminin

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Reproductive Health (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Pregnancy & Childbirth (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
CA3049393A 2009-09-23 2010-09-23 Umbilical cord lining stem cells and methods and material for isolating and culturing same Active CA3049393C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US24512309P 2009-09-23 2009-09-23
US61/245,123 2009-09-23
CA2774612A CA2774612C (en) 2009-09-23 2010-09-23 Umbilical cord lining stem cells and methods and material for isolating and culturing same

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CA2774612A Division CA2774612C (en) 2009-09-23 2010-09-23 Umbilical cord lining stem cells and methods and material for isolating and culturing same

Publications (2)

Publication Number Publication Date
CA3049393A1 CA3049393A1 (en) 2011-03-31
CA3049393C true CA3049393C (en) 2020-12-29

Family

ID=43796487

Family Applications (2)

Application Number Title Priority Date Filing Date
CA2774612A Active CA2774612C (en) 2009-09-23 2010-09-23 Umbilical cord lining stem cells and methods and material for isolating and culturing same
CA3049393A Active CA3049393C (en) 2009-09-23 2010-09-23 Umbilical cord lining stem cells and methods and material for isolating and culturing same

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CA2774612A Active CA2774612C (en) 2009-09-23 2010-09-23 Umbilical cord lining stem cells and methods and material for isolating and culturing same

Country Status (9)

Country Link
US (1) US8778679B2 (enExample)
EP (1) EP2483392B1 (enExample)
CN (1) CN102686722B (enExample)
CA (2) CA2774612C (enExample)
CR (1) CR20120132A (enExample)
ES (1) ES2559937T3 (enExample)
IN (1) IN2012DN02532A (enExample)
MX (1) MX337480B (enExample)
WO (1) WO2011038133A2 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013102219A1 (en) 2011-12-30 2013-07-04 Amit Patel Methods and compositions for the clinical derivation of an allogenic cell and therapeutic uses
US9913466B2 (en) 2014-09-10 2018-03-13 Healthbanks Biotech Co. Ltd. Cryopreservation of umbilical cord tissue strips for cord tissue-derived stem cells
WO2017123312A2 (en) 2015-09-02 2017-07-20 Regeneration Worldwide Company, Inc. Composition and methods of using umbilical cord lining stem cells
US20210355437A1 (en) * 2015-09-02 2021-11-18 Restem Llc Factor rich product from umbilical cord mesenchymal stem cells
US20170233697A1 (en) * 2015-09-02 2017-08-17 Rafael Gonzalez Composition and Methods of Using Umbilical Cord Lining Stem Cells
US10456423B2 (en) 2016-06-13 2019-10-29 SMART SURGICAL, Inc. Compositions for biological systems and methods for preparing and using the same
US10426796B2 (en) 2016-06-13 2019-10-01 SMART SURGICAL, Inc. Compositions for biological systems and methods for preparing and using the same
EP3909593A1 (en) 2020-05-15 2021-11-17 Rigshospitalet Stem cells for treating skin lesions
US20230218572A1 (en) * 2021-12-08 2023-07-13 Versitech Limited Compositions and methods for improved mesenchymal stem cell therapy
WO2023151475A1 (en) * 2022-02-10 2023-08-17 The University Of Hong Kong A method of derivation of mesenchymal stem cells from mammalian pluripotent stem cells
WO2023201258A2 (en) * 2022-04-12 2023-10-19 Avenge Bio, Inc. Encapsulated cells and methods of preserving thereof

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2646438B1 (fr) 1989-03-20 2007-11-02 Pasteur Institut Procede de remplacement specifique d'une copie d'un gene present dans le genome receveur par l'integration d'un gene different de celui ou se fait l'integration
DE69033493D1 (de) 1989-07-25 2004-08-12 Cell Genesys Inc Homologe rekombination für universelle donorzellen und chimerische säugetierzellen
AU2515992A (en) 1991-08-20 1993-03-16 Genpharm International, Inc. Gene targeting in animal cells using isogenic dna constructs
US20030082152A1 (en) 1999-03-10 2003-05-01 Hedrick Marc H. Adipose-derived stem cells and lattices
CN1847393A (zh) * 2000-06-09 2006-10-18 维特罗莱夫公司 添加剂，制剂和培养基
EP1641915B1 (en) * 2003-06-27 2016-07-27 DePuy Synthes Products, Inc. Repair and regeneration of ocular tissue using postpartum-derived cells
US20070196918A1 (en) * 2004-07-15 2007-08-23 Sayre Chauncey B Reprogramming of adult human testicular stem cells to pluripotent germ-line stem cells
JP5668208B2 (ja) * 2004-08-16 2015-02-12 セルリサーチ コーポレイション ピーティイー リミテッド 臍帯羊膜からの幹／前駆細胞の単離
WO2006088867A2 (en) * 2005-02-15 2006-08-24 Medistem Laboratories, Incorporated Method for expansion of stem cells
EP1937326B1 (en) * 2005-10-21 2018-09-12 CellResearch Corporation Pte Ltd Isolation and cultivation of stem/progenitor cells from the amniotic membrane of umbilical cord and uses of cells differentiated therefrom
WO2009015343A2 (en) * 2007-07-25 2009-01-29 Bioe, Inc. Differentiation of multi-lineage progenitor cells to chondrocytes

Also Published As

Publication number Publication date
US20130065302A1 (en) 2013-03-14
CA2774612A1 (en) 2011-03-31
CA2774612C (en) 2019-09-03
CR20120132A (es) 2012-10-30
WO2011038133A2 (en) 2011-03-31
WO2011038133A3 (en) 2011-07-28
CN102686722B (zh) 2014-11-05
IN2012DN02532A (enExample) 2015-08-28
MX337480B (es) 2016-03-08
US8778679B2 (en) 2014-07-15
CN102686722A (zh) 2012-09-19
MX2012003475A (es) 2012-07-20
EP2483392B1 (en) 2015-11-11
EP2483392A4 (en) 2013-07-31
ES2559937T3 (es) 2016-02-16
CA3049393A1 (en) 2011-03-31
EP2483392A2 (en) 2012-08-08

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Effective date: 20190711