CA3047218C - Medical device and method for manufacturing a medical device useful for continuous monitoring of analytes and/or body functions - Google Patents
Medical device and method for manufacturing a medical device useful for continuous monitoring of analytes and/or body functions Download PDFInfo
- Publication number
- CA3047218C CA3047218C CA3047218A CA3047218A CA3047218C CA 3047218 C CA3047218 C CA 3047218C CA 3047218 A CA3047218 A CA 3047218A CA 3047218 A CA3047218 A CA 3047218A CA 3047218 C CA3047218 C CA 3047218C
- Authority
- CA
- Canada
- Prior art keywords
- electrical contact
- conductive layer
- layer
- medical device
- insulation layer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000000034 method Methods 0.000 title claims abstract description 88
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 27
- 238000012544 monitoring process Methods 0.000 title description 19
- 238000009413 insulation Methods 0.000 claims abstract description 265
- 239000000463 material Substances 0.000 claims abstract description 109
- 239000000758 substrate Substances 0.000 claims description 36
- 239000012491 analyte Substances 0.000 claims description 26
- 210000001124 body fluid Anatomy 0.000 claims description 20
- 239000010839 body fluid Substances 0.000 claims description 20
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 16
- 229910052799 carbon Inorganic materials 0.000 claims description 16
- 238000000576 coating method Methods 0.000 claims description 14
- 238000001514 detection method Methods 0.000 claims description 14
- 239000011248 coating agent Substances 0.000 claims description 12
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 claims description 9
- 229910021607 Silver chloride Inorganic materials 0.000 claims description 9
- 238000011156 evaluation Methods 0.000 claims description 9
- 229910052709 silver Inorganic materials 0.000 claims description 9
- 239000004332 silver Substances 0.000 claims description 9
- HKZLPVFGJNLROG-UHFFFAOYSA-M silver monochloride Chemical compound [Cl-].[Ag+] HKZLPVFGJNLROG-UHFFFAOYSA-M 0.000 claims description 9
- 230000013011 mating Effects 0.000 claims description 4
- 238000009530 blood pressure measurement Methods 0.000 claims description 2
- 238000003745 diagnosis Methods 0.000 claims 1
- 239000000306 component Substances 0.000 description 22
- 210000001519 tissue Anatomy 0.000 description 21
- 230000008569 process Effects 0.000 description 17
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 16
- 229910052802 copper Inorganic materials 0.000 description 16
- 239000010949 copper Substances 0.000 description 16
- 238000005259 measurement Methods 0.000 description 14
- 239000004642 Polyimide Substances 0.000 description 11
- 239000004020 conductor Substances 0.000 description 11
- 229920001721 polyimide Polymers 0.000 description 11
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 10
- 229960001031 glucose Drugs 0.000 description 10
- 239000008103 glucose Substances 0.000 description 10
- 239000002245 particle Substances 0.000 description 10
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 9
- 235000001727 glucose Nutrition 0.000 description 9
- 239000012530 fluid Substances 0.000 description 8
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 8
- 229910052737 gold Inorganic materials 0.000 description 8
- 239000010931 gold Substances 0.000 description 8
- 239000000126 substance Substances 0.000 description 8
- 239000012876 carrier material Substances 0.000 description 7
- 238000012360 testing method Methods 0.000 description 7
- 239000002966 varnish Substances 0.000 description 7
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 description 6
- 230000014509 gene expression Effects 0.000 description 6
- 150000002500 ions Chemical class 0.000 description 6
- 238000007639 printing Methods 0.000 description 6
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 5
- 239000000853 adhesive Substances 0.000 description 5
- 230000001070 adhesive effect Effects 0.000 description 5
- 238000005452 bending Methods 0.000 description 5
- 238000001035 drying Methods 0.000 description 5
- 238000003780 insertion Methods 0.000 description 5
- 230000037431 insertion Effects 0.000 description 5
- 238000000059 patterning Methods 0.000 description 5
- 229910000679 solder Inorganic materials 0.000 description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- 241001465754 Metazoa Species 0.000 description 4
- 239000008280 blood Substances 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 4
- 238000000835 electrochemical detection Methods 0.000 description 4
- 210000003722 extracellular fluid Anatomy 0.000 description 4
- 238000001727 in vivo Methods 0.000 description 4
- 239000011810 insulating material Substances 0.000 description 4
- 239000004848 polyfunctional curative Substances 0.000 description 4
- 239000002904 solvent Substances 0.000 description 4
- 108090000790 Enzymes Proteins 0.000 description 3
- 102000004190 Enzymes Human genes 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 3
- 230000008859 change Effects 0.000 description 3
- 230000001419 dependent effect Effects 0.000 description 3
- 239000012777 electrically insulating material Substances 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 229940088598 enzyme Drugs 0.000 description 3
- 229910052763 palladium Inorganic materials 0.000 description 3
- 229920000136 polysorbate Polymers 0.000 description 3
- 108010015776 Glucose oxidase Proteins 0.000 description 2
- 239000004366 Glucose oxidase Substances 0.000 description 2
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 2
- 239000002318 adhesion promoter Substances 0.000 description 2
- 230000036772 blood pressure Effects 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 230000001413 cellular effect Effects 0.000 description 2
- 229910052729 chemical element Inorganic materials 0.000 description 2
- 206010012601 diabetes mellitus Diseases 0.000 description 2
- 229940028356 diethylene glycol monobutyl ether Drugs 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 238000002848 electrochemical method Methods 0.000 description 2
- 229940116332 glucose oxidase Drugs 0.000 description 2
- 235000019420 glucose oxidase Nutrition 0.000 description 2
- 238000002513 implantation Methods 0.000 description 2
- 238000012623 in vivo measurement Methods 0.000 description 2
- 230000033001 locomotion Effects 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- 239000003960 organic solvent Substances 0.000 description 2
- JCGNDDUYTRNOFT-UHFFFAOYSA-N oxolane-2,4-dione Chemical compound O=C1COC(=O)C1 JCGNDDUYTRNOFT-UHFFFAOYSA-N 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 230000002441 reversible effect Effects 0.000 description 2
- 239000000523 sample Substances 0.000 description 2
- 238000007650 screen-printing Methods 0.000 description 2
- 238000007789 sealing Methods 0.000 description 2
- 239000004065 semiconductor Substances 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 238000004544 sputter deposition Methods 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 210000002700 urine Anatomy 0.000 description 2
- 238000005019 vapor deposition process Methods 0.000 description 2
- PGOHTUIFYSHAQG-LJSDBVFPSA-N (2S)-6-amino-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-5-amino-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-amino-2-[[(2S)-1-[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-amino-4-methylsulfanylbutanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-5-carbamimidamidopentanoyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-4-methylpentanoyl]amino]acetyl]amino]-3-hydroxypropanoyl]amino]-4-methylpentanoyl]amino]-3-sulfanylpropanoyl]amino]-4-methylsulfanylbutanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-hydroxybutanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoyl]amino]-3-hydroxypropanoyl]amino]-3-hydroxypropanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-5-carbamimidamidopentanoyl]amino]-5-oxopentanoyl]amino]-3-hydroxybutanoyl]amino]-3-hydroxypropanoyl]amino]-3-carboxypropanoyl]amino]-3-hydroxypropanoyl]amino]-5-oxopentanoyl]amino]-5-oxopentanoyl]amino]-3-phenylpropanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]-4-oxobutanoyl]amino]-5-carbamimidamidopentanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-4-carboxybutanoyl]amino]-5-oxopentanoyl]amino]hexanoic acid Chemical compound CSCC[C@H](N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(O)=O PGOHTUIFYSHAQG-LJSDBVFPSA-N 0.000 description 1
- DURPTKYDGMDSBL-UHFFFAOYSA-N 1-butoxybutane Chemical compound CCCCOCCCC DURPTKYDGMDSBL-UHFFFAOYSA-N 0.000 description 1
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 1
- 102000002262 Thromboplastin Human genes 0.000 description 1
- 108010000499 Thromboplastin Proteins 0.000 description 1
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 1
- 239000004676 acrylonitrile butadiene styrene Substances 0.000 description 1
- 239000000560 biocompatible material Substances 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 210000002808 connective tissue Anatomy 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 230000002844 continuous effect Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 230000001627 detrimental effect Effects 0.000 description 1
- 230000005684 electric field Effects 0.000 description 1
- 238000000840 electrochemical analysis Methods 0.000 description 1
- 238000009713 electroplating Methods 0.000 description 1
- 238000005530 etching Methods 0.000 description 1
- 239000011888 foil Substances 0.000 description 1
- 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 239000008241 heterogeneous mixture Substances 0.000 description 1
- 238000012625 in-situ measurement Methods 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000005304 joining Methods 0.000 description 1
- 238000000608 laser ablation Methods 0.000 description 1
- -1 lipide Chemical compound 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000000691 measurement method Methods 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 210000002381 plasma Anatomy 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 238000005476 soldering Methods 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 125000006850 spacer group Chemical group 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 229920001169 thermoplastic Polymers 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
- A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
- A61B5/1468—Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
- A61B5/6847—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive mounted on an invasive device
- A61B5/6848—Needles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
- A61B5/6867—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive specially adapted to be attached or implanted in a specific body part
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/28—Electrolytic cell components
- G01N27/30—Electrodes, e.g. test electrodes; Half-cells
- G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/28—Electrolytic cell components
- G01N27/30—Electrodes, e.g. test electrodes; Half-cells
- G01N27/327—Biochemical electrodes, e.g. electrical or mechanical details for in vitro measurements
- G01N27/3271—Amperometric enzyme electrodes for analytes in body fluids, e.g. glucose in blood
- G01N27/3272—Test elements therefor, i.e. disposable laminated substrates with electrodes, reagent and channels
-
- H—ELECTRICITY
- H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
- H05K—PRINTED CIRCUITS; CASINGS OR CONSTRUCTIONAL DETAILS OF ELECTRIC APPARATUS; MANUFACTURE OF ASSEMBLAGES OF ELECTRICAL COMPONENTS
- H05K1/00—Printed circuits
- H05K1/02—Details
- H05K1/11—Printed elements for providing electric connections to or between printed circuits
-
- H—ELECTRICITY
- H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
- H05K—PRINTED CIRCUITS; CASINGS OR CONSTRUCTIONAL DETAILS OF ELECTRIC APPARATUS; MANUFACTURE OF ASSEMBLAGES OF ELECTRICAL COMPONENTS
- H05K3/00—Apparatus or processes for manufacturing printed circuits
- H05K3/40—Forming printed elements for providing electric connections to or between printed circuits
- H05K3/4007—Surface contacts, e.g. bumps
- H05K3/4015—Surface contacts, e.g. bumps using auxiliary conductive elements, e.g. pieces of metal foil, metallic spheres
-
- H—ELECTRICITY
- H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
- H05K—PRINTED CIRCUITS; CASINGS OR CONSTRUCTIONAL DETAILS OF ELECTRIC APPARATUS; MANUFACTURE OF ASSEMBLAGES OF ELECTRICAL COMPONENTS
- H05K3/00—Apparatus or processes for manufacturing printed circuits
- H05K3/40—Forming printed elements for providing electric connections to or between printed circuits
- H05K3/403—Edge contacts; Windows or holes in the substrate having plural connections on the walls thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
- A61B2562/12—Manufacturing methods specially adapted for producing sensors for in-vivo measurements
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
- A61B2562/16—Details of sensor housings or probes; Details of structural supports for sensors
- A61B2562/166—Details of sensor housings or probes; Details of structural supports for sensors the sensor is mounted on a specially adapted printed circuit board
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/001—Enzyme electrodes
- C12Q1/005—Enzyme electrodes involving specific analytes or enzymes
- C12Q1/006—Enzyme electrodes involving specific analytes or enzymes for glucose
-
- H—ELECTRICITY
- H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
- H05K—PRINTED CIRCUITS; CASINGS OR CONSTRUCTIONAL DETAILS OF ELECTRIC APPARATUS; MANUFACTURE OF ASSEMBLAGES OF ELECTRICAL COMPONENTS
- H05K2201/00—Indexing scheme relating to printed circuits covered by H05K1/00
- H05K2201/10—Details of components or other objects attached to or integrated in a printed circuit board
- H05K2201/10007—Types of components
- H05K2201/10151—Sensor
-
- H—ELECTRICITY
- H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
- H05K—PRINTED CIRCUITS; CASINGS OR CONSTRUCTIONAL DETAILS OF ELECTRIC APPARATUS; MANUFACTURE OF ASSEMBLAGES OF ELECTRICAL COMPONENTS
- H05K3/00—Apparatus or processes for manufacturing printed circuits
- H05K3/10—Apparatus or processes for manufacturing printed circuits in which conductive material is applied to the insulating support in such a manner as to form the desired conductive pattern
- H05K3/12—Apparatus or processes for manufacturing printed circuits in which conductive material is applied to the insulating support in such a manner as to form the desired conductive pattern using thick film techniques, e.g. printing techniques to apply the conductive material or similar techniques for applying conductive paste or ink patterns
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Pathology (AREA)
- Biophysics (AREA)
- Chemical & Material Sciences (AREA)
- Surgery (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medical Informatics (AREA)
- Heart & Thoracic Surgery (AREA)
- Optics & Photonics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microelectronics & Electronic Packaging (AREA)
- Emergency Medicine (AREA)
- Electrochemistry (AREA)
- Immunology (AREA)
- General Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Manufacturing & Machinery (AREA)
- Hematology (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
- Measuring And Recording Apparatus For Diagnosis (AREA)
- Electrotherapy Devices (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17161991.9 | 2017-03-21 | ||
| EP17161991 | 2017-03-21 | ||
| PCT/EP2018/057007 WO2018172349A1 (en) | 2017-03-21 | 2018-03-20 | Medical device and method for manufacturing a medical device |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA3047218A1 CA3047218A1 (en) | 2018-09-27 |
| CA3047218C true CA3047218C (en) | 2023-08-29 |
Family
ID=58401416
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3047218A Active CA3047218C (en) | 2017-03-21 | 2018-03-20 | Medical device and method for manufacturing a medical device useful for continuous monitoring of analytes and/or body functions |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US10806387B2 (enExample) |
| EP (1) | EP3600035B1 (enExample) |
| JP (1) | JP7142642B2 (enExample) |
| CN (1) | CN110430814B (enExample) |
| CA (1) | CA3047218C (enExample) |
| ES (1) | ES3032635T3 (enExample) |
| HU (1) | HUE071675T2 (enExample) |
| RU (1) | RU2738794C1 (enExample) |
| WO (1) | WO2018172349A1 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2996196C (en) | 2015-08-31 | 2024-06-11 | Masimo Corporation | Wireless patient monitoring systems and methods |
| ES3032635T3 (en) * | 2017-03-21 | 2025-07-22 | Hoffmann La Roche | Medical device and method for manufacturing a medical device |
| US11872156B2 (en) | 2018-08-22 | 2024-01-16 | Masimo Corporation | Core body temperature measurement |
| BR112021020780A2 (pt) | 2019-04-17 | 2021-12-14 | Masimo Corp | Dispositivo de eletrocardiograma (ecg), dispositivo de monitoramento de pressão sanguínea, monitor de pressão sanguínea, manguito de pressão sanguínea, montagem para possibilitar que um cuidador prenda um dispositivo de monitoramento fisiológico a um braço de um usuário, estação de carregamento para fornecer energia para um dispositivo de monitoramento fisiológico, monitor de pressão sanguínea não invasivo e método para um monitor de pressão sanguínea não invasivo |
| AU2020263282A1 (en) | 2019-04-22 | 2021-11-04 | Dexcom, Inc. | Preconnected analyte sensors |
| USD917704S1 (en) | 2019-08-16 | 2021-04-27 | Masimo Corporation | Patient monitor |
| USD919100S1 (en) | 2019-08-16 | 2021-05-11 | Masimo Corporation | Holder for a patient monitor |
| WO2021188999A2 (en) * | 2020-03-20 | 2021-09-23 | Masimo Corporation | Health monitoring system for limiting the spread of an infection in an organization |
| USD933232S1 (en) | 2020-05-11 | 2021-10-12 | Masimo Corporation | Blood pressure monitor |
| CN115515502B (zh) | 2020-05-08 | 2025-11-18 | W.L.戈尔及同仁股份有限公司 | 经皮声音传感器 |
| USD974193S1 (en) | 2020-07-27 | 2023-01-03 | Masimo Corporation | Wearable temperature measurement device |
| USD1072837S1 (en) | 2020-10-27 | 2025-04-29 | Masimo Corporation | Display screen or portion thereof with graphical user interface |
| USD1000975S1 (en) | 2021-09-22 | 2023-10-10 | Masimo Corporation | Wearable temperature measurement device |
| USD1048908S1 (en) | 2022-10-04 | 2024-10-29 | Masimo Corporation | Wearable sensor |
Family Cites Families (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5413690A (en) | 1993-07-23 | 1995-05-09 | Boehringer Mannheim Corporation | Potentiometric biosensor and the method of its use |
| US5762770A (en) | 1994-02-21 | 1998-06-09 | Boehringer Mannheim Corporation | Electrochemical biosensor test strip |
| US6044441A (en) | 1995-09-29 | 2000-03-28 | Intel Corporation | Method and apparatus for encoding valid and invalid states in a cache with an invalid pattern |
| JP3365184B2 (ja) | 1996-01-10 | 2003-01-08 | 松下電器産業株式会社 | バイオセンサ |
| US5798031A (en) | 1997-05-12 | 1998-08-25 | Bayer Corporation | Electrochemical biosensor |
| KR100568491B1 (ko) | 1997-07-04 | 2006-04-07 | 제온 코포레이션 | 반도체부품 접착제 |
| US6309526B1 (en) | 1997-07-10 | 2001-10-30 | Matsushita Electric Industrial Co., Ltd. | Biosensor |
| US5997817A (en) | 1997-12-05 | 1999-12-07 | Roche Diagnostics Corporation | Electrochemical biosensor test strip |
| US6175752B1 (en) * | 1998-04-30 | 2001-01-16 | Therasense, Inc. | Analyte monitoring device and methods of use |
| US6360888B1 (en) | 1999-02-25 | 2002-03-26 | Minimed Inc. | Glucose sensor package system |
| KR100305750B1 (ko) | 1999-03-10 | 2001-09-24 | 윤덕용 | 플라스틱 기판의 플립 칩 접속용 이방성 전도성 접착제의 제조방법 |
| US6287451B1 (en) | 1999-06-02 | 2001-09-11 | Handani Winarta | Disposable sensor and method of making |
| US20050103624A1 (en) | 1999-10-04 | 2005-05-19 | Bhullar Raghbir S. | Biosensor and method of making |
| CN1220053C (zh) | 1999-11-15 | 2005-09-21 | 松下电器产业株式会社 | 生物传感器、定量装置及定量方法 |
| RU2267131C2 (ru) | 2000-03-31 | 2005-12-27 | Лайфскен, Инк. | Электропроводные структуры для контроля заполнения медицинских устройств |
| AU2005246102B8 (en) * | 2004-05-21 | 2010-09-30 | Agamatrix, Inc. | Electrochemical cell and method of making an electrochemical cell |
| US20140163664A1 (en) * | 2006-11-21 | 2014-06-12 | David S. Goldsmith | Integrated system for the ballistic and nonballistic infixion and retrieval of implants with or without drug targeting |
| EP1972267A1 (de) | 2007-03-20 | 2008-09-24 | Roche Diagnostics GmbH | System zur in-vivo Messung einer Analytkonzentration |
| JP2010531169A (ja) * | 2007-06-21 | 2010-09-24 | アボット ダイアベティス ケア インコーポレイテッド | 健康監視装置 |
| AU2008279043A1 (en) * | 2007-07-26 | 2009-01-29 | Agamatrix, Inc. | Electrochemical test strips |
| EP2205757B1 (en) | 2007-10-31 | 2017-06-14 | Roche Diabetes Care GmbH | Electrical patterns for biosensor and method of making |
| EP4309580A3 (en) | 2009-07-23 | 2024-02-28 | Abbott Diabetes Care Inc. | Continuous analyte measurement system |
| US8323467B2 (en) * | 2009-10-27 | 2012-12-04 | Lifescan Scotland Limited | Dual chamber, multi-analyte test strip with opposing electrodes |
| US10448872B2 (en) * | 2010-03-16 | 2019-10-22 | Medtronic Minimed, Inc. | Analyte sensor apparatuses having improved electrode configurations and methods for making and using them |
| KR20110121662A (ko) | 2010-08-03 | 2011-11-08 | 삼성전기주식회사 | 터치패널 및 그 제조방법 |
| DK2621339T3 (da) * | 2010-09-29 | 2020-02-24 | Dexcom Inc | Avanceret system til kontinuerlig analytmonitorering |
| GB201022028D0 (en) * | 2010-12-23 | 2011-02-02 | Sca Hygiene Prod Ab | Tool for analysing liquid discharge data in an absorbent article, an absorbent article adapted for liquid dicharge data collection and a control unit |
| JP5819183B2 (ja) * | 2011-02-03 | 2015-11-18 | アークレイ株式会社 | 分析装置、センサの検査装置、検査方法、及び検査プログラム |
| WO2012158834A1 (en) * | 2011-05-16 | 2012-11-22 | Second Sight Medical Products, Inc. | Cortical interface with an electrode array divided into separate fingers and/or with a wireless transceiver |
| EP2720610B1 (en) * | 2011-06-17 | 2025-07-16 | Abbott Diabetes Care Inc. | Stacked analyte sensor having a first electrode narrower than a second electrode of the sensor |
| US9498617B2 (en) * | 2012-06-19 | 2016-11-22 | Lawrence Livermore National Security, Llc | Conformally encapsulated multi-electrode arrays with seamless insulation |
| EP2679156B1 (en) * | 2012-06-28 | 2019-10-02 | Roche Diabetes Care GmbH | Device for monitoring at least one body function of a user and method for manufacturing the same |
| EP2866657B1 (en) * | 2012-06-29 | 2021-02-24 | Roche Diabetes Care GmbH | Sensor element for detecting an analyte in a body fluid |
| JP6246211B2 (ja) * | 2012-09-07 | 2017-12-13 | シラグ・ゲーエムベーハー・インターナショナルＣｉｌａｇ ＧＭＢＨ Ｉｎｔｅｒｎａｔｉｏｎａｌ | 電気化学センサ及びそれらの製造のための方法 |
| US9949376B2 (en) * | 2013-12-06 | 2018-04-17 | Second Sight Medical Products, Inc. | Cortical implant system for brain stimulation and recording |
| FR3015228B1 (fr) * | 2013-12-19 | 2018-03-09 | Commissariat A L'energie Atomique Et Aux Energies Alternatives | Article a appliquer sur la peau, les muqueuses ou une plaie |
| US10105082B2 (en) * | 2014-08-15 | 2018-10-23 | International Business Machines Corporation | Metal-oxide-semiconductor capacitor based sensor |
| EP3277370A1 (en) * | 2015-03-31 | 2018-02-07 | Cardiac Pacemakers, Inc. | Encapsulated filtered feedthrough for implantable medical devices |
| JP6524780B2 (ja) * | 2015-04-20 | 2019-06-05 | セイコーエプソン株式会社 | 電気配線部材の製造方法、電気配線部材形成用材料、電気配線部材、電気配線基板の製造方法、電気配線基板形成用材料、電気配線基板、振動子、電子機器および移動体 |
| ES3032635T3 (en) * | 2017-03-21 | 2025-07-22 | Hoffmann La Roche | Medical device and method for manufacturing a medical device |
| US10478617B2 (en) * | 2017-05-17 | 2019-11-19 | Verily Life Sciences Llc | Thin-film electrode assembly with soft overmold |
-
2018
- 2018-03-20 ES ES18711948T patent/ES3032635T3/es active Active
- 2018-03-20 EP EP18711948.2A patent/EP3600035B1/en active Active
- 2018-03-20 CN CN201880019996.7A patent/CN110430814B/zh active Active
- 2018-03-20 JP JP2019551383A patent/JP7142642B2/ja active Active
- 2018-03-20 WO PCT/EP2018/057007 patent/WO2018172349A1/en not_active Ceased
- 2018-03-20 RU RU2019132691A patent/RU2738794C1/ru active
- 2018-03-20 HU HUE18711948A patent/HUE071675T2/hu unknown
- 2018-03-20 CA CA3047218A patent/CA3047218C/en active Active
-
2019
- 2019-09-06 US US16/562,949 patent/US10806387B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| EP3600035A1 (en) | 2020-02-05 |
| JP2020511240A (ja) | 2020-04-16 |
| JP7142642B2 (ja) | 2022-09-27 |
| CA3047218A1 (en) | 2018-09-27 |
| CN110430814A (zh) | 2019-11-08 |
| ES3032635T3 (en) | 2025-07-22 |
| WO2018172349A1 (en) | 2018-09-27 |
| EP3600035B1 (en) | 2025-04-23 |
| CN110430814B (zh) | 2022-04-26 |
| US20190388013A1 (en) | 2019-12-26 |
| EP3600035C0 (en) | 2025-04-23 |
| US10806387B2 (en) | 2020-10-20 |
| HUE071675T2 (hu) | 2025-09-28 |
| RU2738794C1 (ru) | 2020-12-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA3047218C (en) | Medical device and method for manufacturing a medical device useful for continuous monitoring of analytes and/or body functions | |
| US10349878B2 (en) | Electrochemical sensor having symmetrically distributed analyte sensitive areas | |
| US8038859B2 (en) | Electrochemical sensor and method for analyzing liquid sample | |
| EP3195795B1 (en) | Sensor assembly and method for detecting at least one analyte in a body fluid | |
| US20230346273A1 (en) | Electrochemical sensor having symmetrically distributed analyte sensitive areas | |
| RU2753170C1 (ru) | Электрохимический сенсор и сенсорная система для определения по меньшей мере одного аналита | |
| HK40017149B (en) | Medical device and method for manufacturing a medical device | |
| HK40017149A (en) | Medical device and method for manufacturing a medical device | |
| CN111278360B (zh) | 用于检测体液中的分析物的传感器以及制造传感器的方法 | |
| HK40029615A (en) | Electrochemical sensor and sensor system for detecting at least one analyte | |
| HK40029615B (en) | Electrochemical sensor and sensor system for detecting at least one analyte |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20190614 |
|
| EEER | Examination request |
Effective date: 20190614 |
|
| EEER | Examination request |
Effective date: 20190614 |
|
| EEER | Examination request |
Effective date: 20190614 |
|
| EEER | Examination request |
Effective date: 20190614 |
|
| EEER | Examination request |
Effective date: 20190614 |
|
| EEER | Examination request |
Effective date: 20190614 |
|
| EEER | Examination request |
Effective date: 20190614 |