CA3044416A1 - Multivalent regulatory t cell modulators - Google Patents
Multivalent regulatory t cell modulators Download PDFInfo
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- CA3044416A1 CA3044416A1 CA3044416A CA3044416A CA3044416A1 CA 3044416 A1 CA3044416 A1 CA 3044416A1 CA 3044416 A CA3044416 A CA 3044416A CA 3044416 A CA3044416 A CA 3044416A CA 3044416 A1 CA3044416 A1 CA 3044416A1
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- C12N15/09—Recombinant DNA-technology
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/71—Decreased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
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| US201662433533P | 2016-12-13 | 2016-12-13 | |
| US62/433,533 | 2016-12-13 | ||
| PCT/US2017/066163 WO2018112069A1 (en) | 2016-12-13 | 2017-12-13 | Multivalent regulatory t cell modulators |
Publications (1)
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| CA3044416A1 true CA3044416A1 (en) | 2018-06-21 |
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| CA3044416A Abandoned CA3044416A1 (en) | 2016-12-13 | 2017-12-13 | Multivalent regulatory t cell modulators |
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| EP (1) | EP3554525A4 (enExample) |
| JP (1) | JP7228515B2 (enExample) |
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| RU (1) | RU2769871C2 (enExample) |
| WO (1) | WO2018112069A1 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2015042521A1 (en) | 2013-09-20 | 2015-03-26 | University Of Virginia Patent Foundation | Compositions and methods for treatment of autoimmune and inflammatory diseases and disorders |
| WO2018112069A1 (en) | 2016-12-13 | 2018-06-21 | Delinia, Inc. | Multivalent regulatory t cell modulators |
| JP7165717B2 (ja) | 2017-03-15 | 2022-11-04 | パンディオン・オペレーションズ・インコーポレイテッド | 標的免疫寛容 |
| MX2019013517A (es) | 2017-05-24 | 2020-08-17 | Pandion Operations Inc | Inmunotolerancia dirigida. |
| US10946068B2 (en) | 2017-12-06 | 2021-03-16 | Pandion Operations, Inc. | IL-2 muteins and uses thereof |
| US10174091B1 (en) | 2017-12-06 | 2019-01-08 | Pandion Therapeutics, Inc. | IL-2 muteins |
| USRE50550E1 (en) | 2017-12-06 | 2025-08-26 | Pandion Operations, Inc. | IL-2 muteins and uses thereof |
| CA3108865A1 (en) | 2018-08-06 | 2020-02-13 | Medikine, Inc. | Il-2 receptor binding compounds |
| CN113286814A (zh) * | 2018-10-31 | 2021-08-20 | 德里尼亚公司 | 多价调节性t细胞调节子 |
| EP3972992A4 (en) | 2019-05-20 | 2023-07-19 | Pandion Operations, Inc. | MADCAM TARGETED IMMUNOTLERANCE |
| EP3986448A4 (en) * | 2019-06-19 | 2023-07-12 | Cue Biopharma, Inc. | MULTIMERIC T-CELL-MODULATING POLYPEPTIDES AND METHODS OF USE THEREOF |
| CN114853874B (zh) * | 2019-09-10 | 2024-05-17 | 中国医学科学院北京协和医院 | 靶向调节t细胞的长效白介素-2及其在治疗自身免疫病中的应用 |
| AU2020378282B2 (en) | 2019-11-05 | 2023-05-18 | Medikine, Inc. | Dual IL-2R and IL-7R binding compounds |
| JP7427286B2 (ja) | 2019-11-05 | 2024-02-05 | メディカイン、インコーポレイテッド | ＩＬ－２ＲβγＣ結合化合物 |
| KR20220139918A (ko) | 2020-02-03 | 2022-10-17 | 메디카인 인코포레이티드 | IL-7Rαγc 결합 화합물 |
| JP2023512687A (ja) | 2020-02-03 | 2023-03-28 | メディカイン、インコーポレイテッド | ＩＬ－７Ｒα結合化合物 |
| WO2021168079A1 (en) | 2020-02-21 | 2021-08-26 | Pandion Operations, Inc. | Tissue targeted immunotolerance with a cd39 effector |
| US11999771B2 (en) | 2022-04-07 | 2024-06-04 | Medikine, Inc. | IL-7Rαγc ligand immunoglobulin fusion proteins |
| CN119213020A (zh) * | 2022-05-11 | 2024-12-27 | 斯雷特生物股份有限公司 | 包含截短的白细胞介素-33和白细胞介素-2的组合物 |
| WO2025106677A1 (en) * | 2023-11-15 | 2025-05-22 | Slate Bio, Inc. | Bifunctional il-2 and il-33 proteins for treating autoimmune disease |
Family Cites Families (12)
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| US5731168A (en) * | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
| DZ2788A1 (fr) * | 1998-05-15 | 2003-12-01 | Bayer Ag | Agonistes et antagonistes selectifs à IL-2. |
| JP4944324B2 (ja) * | 1999-07-13 | 2012-05-30 | ボルダー バイオテクノロジー， インコーポレイテッド | 免疫グロブリン融合タンパク質 |
| JP2007506681A (ja) * | 2003-09-23 | 2007-03-22 | ピーディーエル バイオファーマ，インコーポレイティド | 抗ｉｌ−２受容体抗体による呼吸器疾患の治療 |
| JO3623B1 (ar) | 2012-05-18 | 2020-08-27 | Amgen Inc | البروتينات المرتبطة بمولد المستضاد st2 |
| CA2878843A1 (en) * | 2012-07-13 | 2014-01-16 | Zymeworks Inc. | Bispecific asymmetric heterodimers comprising anti-cd3 constructs |
| KR102545617B1 (ko) * | 2012-11-28 | 2023-06-20 | 자임워크스 비씨 인코포레이티드 | 가공된 면역글로불린 중쇄-경쇄 쌍 및 이들의 용도 |
| CA3093606A1 (en) * | 2013-03-15 | 2014-09-18 | Xencor, Inc. | Heterodimeric proteins for induction of t cells |
| WO2015042521A1 (en) * | 2013-09-20 | 2015-03-26 | University Of Virginia Patent Foundation | Compositions and methods for treatment of autoimmune and inflammatory diseases and disorders |
| PE20161324A1 (es) * | 2014-02-06 | 2016-11-25 | Hoffmann La Roche | Proteinas de fusion de interleucina-2 y usos de las mismas |
| DK3172227T3 (da) * | 2014-07-21 | 2019-12-02 | Delinia Inc | Molekyler der selektivt aktiverer regulatoriske t-celler til behandlingen af autoimmune sygdomme |
| WO2018112069A1 (en) | 2016-12-13 | 2018-06-21 | Delinia, Inc. | Multivalent regulatory t cell modulators |
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2017
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- 2017-12-13 CA CA3044416A patent/CA3044416A1/en not_active Abandoned
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- 2017-12-13 MX MX2019007002A patent/MX381276B/es unknown
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- 2017-12-13 US US15/840,721 patent/US10472405B2/en active Active
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- 2017-12-13 KR KR1020197020221A patent/KR20190094222A/ko not_active Ceased
- 2017-12-13 CN CN201780076808.XA patent/CN110177564A/zh active Pending
- 2017-12-13 JP JP2019531303A patent/JP7228515B2/ja active Active
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2019
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- 2019-10-17 US US16/655,544 patent/US11059877B2/en not_active Expired - Fee Related
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| JP7228515B2 (ja) | 2023-02-24 |
| RU2769871C2 (ru) | 2022-04-07 |
| KR20190094222A (ko) | 2019-08-12 |
| BR112019011799B1 (pt) | 2021-12-21 |
| BR112019011799A2 (pt) | 2019-10-29 |
| US11059877B2 (en) | 2021-07-13 |
| MX381276B (es) | 2025-03-12 |
| WO2018112069A1 (en) | 2018-06-21 |
| CN110177564A (zh) | 2019-08-27 |
| US10472405B2 (en) | 2019-11-12 |
| RU2019121902A (ru) | 2021-01-18 |
| MX2021004007A (es) | 2021-06-23 |
| US20200031897A1 (en) | 2020-01-30 |
| EP3554525A1 (en) | 2019-10-23 |
| BR122020025384B1 (pt) | 2022-07-12 |
| AU2017378308A1 (en) | 2019-06-20 |
| EP3554525A4 (en) | 2020-08-19 |
| MX2019007002A (es) | 2019-08-22 |
| JP2020501550A (ja) | 2020-01-23 |
| RU2019121902A3 (enExample) | 2021-04-21 |
| US20180162919A1 (en) | 2018-06-14 |
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Effective date: 20240325 |