CA3042459C - Effet protecteur de dmpc, dmpg, dmpc/dmpg, lysopg et lysopc contre des medicaments provoquant des canalopathies - Google Patents

Effet protecteur de dmpc, dmpg, dmpc/dmpg, lysopg et lysopc contre des medicaments provoquant des canalopathies Download PDF

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Publication number
CA3042459C
CA3042459C CA3042459A CA3042459A CA3042459C CA 3042459 C CA3042459 C CA 3042459C CA 3042459 A CA3042459 A CA 3042459A CA 3042459 A CA3042459 A CA 3042459A CA 3042459 C CA3042459 C CA 3042459C
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CA
Canada
Prior art keywords
cardiac
dmpg
nilotinib
lipids
dmpc
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA3042459A
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English (en)
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CA3042459A1 (fr
Inventor
Lawrence Helson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Signpath Pharma Inc
Original Assignee
Signpath Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US15/347,381 external-priority patent/US10117881B2/en
Application filed by Signpath Pharma Inc filed Critical Signpath Pharma Inc
Publication of CA3042459A1 publication Critical patent/CA3042459A1/fr
Application granted granted Critical
Publication of CA3042459C publication Critical patent/CA3042459C/fr
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Dispersion Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

La présente invention concerne des compositions et des méthodes utiles pour prévenir un ou plusieurs états ou canalopathies cardiaques résultant d'irrégularités ou modifications de types cardiaques provoquées par un agent actif ou un médicament chez un sujet humain ou animal, comprenant: une quantité d'un composé de lysophosphatidyle conçu pour une administration par voie orale efficace pour réduire ou prévenir un ou plusieurs états ou canalopathies cardiaques résultant d'irrégularités ou modifications de types cardiaques provoquées par l'agent actif ou le médicament.
CA3042459A 2016-11-09 2017-11-09 Effet protecteur de dmpc, dmpg, dmpc/dmpg, lysopg et lysopc contre des medicaments provoquant des canalopathies Active CA3042459C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US15/347,381 US10117881B2 (en) 2011-06-03 2016-11-09 Protective effect of DMPC, DMPG, DMPC/DMPG, LYSOPG and LYSOPC against drugs that cause channelopathies
US15/347,381 2016-11-09
PCT/US2017/060936 WO2018089687A1 (fr) 2016-11-09 2017-11-09 Effet protecteur de dmpc, dmpg, dmpc/dmpg, lysopg et lysopc contre des médicaments provoquant des canalopathies

Publications (2)

Publication Number Publication Date
CA3042459A1 CA3042459A1 (fr) 2018-05-17
CA3042459C true CA3042459C (fr) 2022-08-16

Family

ID=62109333

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3042459A Active CA3042459C (fr) 2016-11-09 2017-11-09 Effet protecteur de dmpc, dmpg, dmpc/dmpg, lysopg et lysopc contre des medicaments provoquant des canalopathies

Country Status (8)

Country Link
EP (1) EP3538106A4 (fr)
JP (1) JP2019533692A (fr)
KR (3) KR20190067918A (fr)
CN (1) CN110167562A (fr)
AU (1) AU2017357916B2 (fr)
CA (1) CA3042459C (fr)
MX (1) MX2019005141A (fr)
WO (1) WO2018089687A1 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110291089B (zh) 2017-01-17 2022-05-27 海帕瑞吉尼克斯股份有限公司 用于促进肝再生或者减少或预防肝细胞死亡的蛋白激酶抑制剂
US10835529B2 (en) 2017-05-16 2020-11-17 Bow River LLC Methods of treatment with CYP3A4 substrate drugs
US20220143011A1 (en) 2017-05-16 2022-05-12 Bow River LLC Methods of treatment with cyp3a4 substrate drugs
US10857144B2 (en) 2017-05-16 2020-12-08 Bow River LLC Methods of treatment
HRP20220536T1 (hr) 2017-05-16 2022-06-10 Bow River LLC Liječenje pacijenta lijekom supstratom cyp3a4 koji je kontraindiciran za istodobnu primjenu s jakim inhibitorom cyp3a4
US11610660B1 (en) 2021-08-20 2023-03-21 AltaThera Pharmaceuticals LLC Antiarrhythmic drug dosing methods, medical devices, and systems
US11696902B2 (en) 2018-08-14 2023-07-11 AltaThera Pharmaceuticals, LLC Method of initiating and escalating sotalol hydrochloride dosing
JP2024039728A (ja) * 2022-09-12 2024-03-25 賢一郎 蓮見 抗腫瘍免疫応答増強剤

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4812312A (en) * 1987-03-03 1989-03-14 Board Of Regents Of The University Of Texas System Liposome-incorporated nystatin
JPH10279487A (ja) * 1997-04-01 1998-10-20 Nippon Shokuhin Kako Co Ltd 脂質代謝改善剤
US20100068251A1 (en) * 2006-10-10 2010-03-18 Jina Pharmaceuticals, Inc. Aqueous Systems For The Preparation Of Lipid Based Pharmaceutical Compounds; Compositions, Methods, And Uses Thereof
WO2012054718A2 (fr) * 2010-10-22 2012-04-26 The General Hospital Corporation Traitement du syndrome du qt long
US10117881B2 (en) * 2011-06-03 2018-11-06 Signpath Pharma, Inc. Protective effect of DMPC, DMPG, DMPC/DMPG, LYSOPG and LYSOPC against drugs that cause channelopathies
EP2714011B1 (fr) * 2011-06-03 2018-01-31 Signpath Pharma Inc. Atténuation liposomale du syndrome du qt long induit par un médicament et du courant de potassium à redressement retardé
CA2933204C (fr) * 2013-12-18 2020-04-28 Signpath Pharma, Inc. Attenuation liposomale de l'inhibition induite par medicament du canal ikr cardiaque
AU2015269699B2 (en) * 2014-06-03 2020-08-13 Avanti Polar Lipids, Inc. Protective effect of DMPC, DMPG, DMPC/DMPG, EGPG, LysoPG and LysoPC against drugs that cause channelopathies

Also Published As

Publication number Publication date
CN110167562A (zh) 2019-08-23
CA3042459A1 (fr) 2018-05-17
MX2019005141A (es) 2019-09-26
KR20190067918A (ko) 2019-06-17
EP3538106A4 (fr) 2021-03-24
AU2017357916B2 (en) 2020-11-26
WO2018089687A1 (fr) 2018-05-17
EP3538106A1 (fr) 2019-09-18
JP2019533692A (ja) 2019-11-21
KR20230110823A (ko) 2023-07-25
AU2017357916A1 (en) 2019-05-30
KR20200108371A (ko) 2020-09-17

Similar Documents

Publication Publication Date Title
US10117881B2 (en) Protective effect of DMPC, DMPG, DMPC/DMPG, LYSOPG and LYSOPC against drugs that cause channelopathies
CA3042459C (fr) Effet protecteur de dmpc, dmpg, dmpc/dmpg, lysopg et lysopc contre des medicaments provoquant des canalopathies
US10357458B2 (en) Liposomal mitigation of drug-induced long QT syndrome and potassium delayed-rectifier current
AU2016266020B2 (en) Protective effect of dmpc, dmpg, dmpc/dmpg, egpg, lysopg and lysopc against drugs that cause channelopathies
EP3082768B1 (fr) Atténuation liposomale de l'inhibition induite par médicament du canal ikr cardiaque
US10449193B2 (en) Protective effect of DMPC, DMPG, DMPC/DMPG, lysoPG and lysoPC against drugs that cause channelopathies
US11643424B2 (en) Cardiopathy-reducing phosphodiester lipids
EP3326616A1 (fr) Atténuation liposomale du syndrome du qt long induit par un médicament et du courant de potassium à redressement retardé
WO2024064536A1 (fr) Lipide cardioprotecteur et procédé d'utilisation
TW202417005A (zh) 保護心臟之脂質及使用方法

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Effective date: 20190430

EEER Examination request

Effective date: 20190430