CA3034810C - In-situ solvent recycling process for solid phase peptide synthesis at elevated temperatures - Google Patents

In-situ solvent recycling process for solid phase peptide synthesis at elevated temperatures Download PDF

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Publication number
CA3034810C
CA3034810C CA3034810A CA3034810A CA3034810C CA 3034810 C CA3034810 C CA 3034810C CA 3034810 A CA3034810 A CA 3034810A CA 3034810 A CA3034810 A CA 3034810A CA 3034810 C CA3034810 C CA 3034810C
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CA
Canada
Prior art keywords
coupling
deprotection
solid phase
cycle
phase peptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA3034810A
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English (en)
French (fr)
Other versions
CA3034810A1 (en
Inventor
Jonathan M. Collins
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CEM Corp
Original Assignee
CEM Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/US2016/058181 external-priority patent/WO2017070512A1/en
Priority claimed from US15/490,090 external-priority patent/US10239914B2/en
Application filed by CEM Corp filed Critical CEM Corp
Publication of CA3034810A1 publication Critical patent/CA3034810A1/en
Application granted granted Critical
Publication of CA3034810C publication Critical patent/CA3034810C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/045—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers using devices to improve synthesis, e.g. reactors, special vessels
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C07K1/047—Simultaneous synthesis of different peptide species; Peptide libraries
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
CA3034810A 2016-09-03 2017-04-19 In-situ solvent recycling process for solid phase peptide synthesis at elevated temperatures Active CA3034810C (en)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201662383397P 2016-09-03 2016-09-03
US62/383,397 2016-09-03
US15/299,931 2016-10-21
USPCT/US2016/058181 2016-10-21
PCT/US2016/058181 WO2017070512A1 (en) 2015-10-23 2016-10-21 Improvements in solid phase peptide synthesis
US15/299,931 US10125163B2 (en) 2015-10-23 2016-10-21 Solid phase peptide synthesis
US15/490,090 2017-04-18
US15/490,090 US10239914B2 (en) 2015-10-23 2017-04-18 In-situ solvent recycling process for solid phase peptide synthesis at elevated temperatures
PCT/US2017/028254 WO2018044356A1 (en) 2016-09-03 2017-04-19 In-situ solvent recycling process for solid phase peptide synthesis at elevated temperatures

Publications (2)

Publication Number Publication Date
CA3034810A1 CA3034810A1 (en) 2018-03-08
CA3034810C true CA3034810C (en) 2023-09-05

Family

ID=61301481

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3034810A Active CA3034810C (en) 2016-09-03 2017-04-19 In-situ solvent recycling process for solid phase peptide synthesis at elevated temperatures

Country Status (6)

Country Link
EP (1) EP3507299B1 (https=)
JP (1) JP2019530659A (https=)
CN (1) CN109715647A (https=)
CA (1) CA3034810C (https=)
DK (1) DK3507299T3 (https=)
WO (1) WO2018044356A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
USRE49961E1 (en) 2016-10-21 2024-05-07 Cem Corporation Solid phase peptide syntheses
EP4551587A1 (en) * 2022-09-16 2025-05-14 CEM Corporation Peptide synthesis processes

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040238794A1 (en) * 2003-05-30 2004-12-02 Karandikar Prashant G. Microwave processing of composite bodies made by an infiltration route
US7902488B2 (en) * 2003-06-23 2011-03-08 Cem Corporation Microwave-assisted peptide synthesis
US7393920B2 (en) * 2003-06-23 2008-07-01 Cem Corporation Microwave-assisted peptide synthesis
WO2006026184A2 (en) * 2004-08-20 2006-03-09 Washington University Blood brain barrier permeation peptides
US8314208B2 (en) * 2006-02-10 2012-11-20 Cem Corporation Microwave enhanced N-fmoc deprotection in peptide synthesis
JP2013534247A (ja) * 2010-08-16 2013-09-02 シーイーエム・コーポレーション 水溶性固相ペプチド合成
US8906681B2 (en) * 2011-08-02 2014-12-09 The Scripps Research Institute Reliable stabilization of N-linked polypeptide native states with enhanced aromatic sequons located in polypeptide tight turns
EP2703073A1 (en) * 2012-08-31 2014-03-05 Biotage AB Apparatus and method for solid phase synthesis
US9169287B2 (en) * 2013-03-15 2015-10-27 Massachusetts Institute Of Technology Solid phase peptide synthesis processes and associated systems
EP3365352A4 (en) * 2015-10-23 2019-06-05 CEM Corporation IMPROVEMENTS OF SOLID PHASE PEPTIDE SYNTHESIS

Also Published As

Publication number Publication date
EP3507299A4 (en) 2020-04-29
EP3507299B1 (en) 2022-07-27
CN109715647A (zh) 2019-05-03
CA3034810A1 (en) 2018-03-08
EP3507299A1 (en) 2019-07-10
DK3507299T3 (da) 2022-09-05
WO2018044356A1 (en) 2018-03-08
JP2019530659A (ja) 2019-10-24

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