CA3030930A1 - Analogues de l'insuline - Google Patents
Analogues de l'insuline Download PDFInfo
- Publication number
- CA3030930A1 CA3030930A1 CA3030930A CA3030930A CA3030930A1 CA 3030930 A1 CA3030930 A1 CA 3030930A1 CA 3030930 A CA3030930 A CA 3030930A CA 3030930 A CA3030930 A CA 3030930A CA 3030930 A1 CA3030930 A1 CA 3030930A1
- Authority
- CA
- Canada
- Prior art keywords
- absent
- leu
- val
- glu
- thr
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
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- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B15/00—ICT specially adapted for analysing two-dimensional or three-dimensional molecular structures, e.g. structural or functional relations or structure alignment
- G16B15/30—Drug targeting using structural data; Docking or binding prediction
-
- C—CHEMISTRY; METALLURGY
- C30—CRYSTAL GROWTH
- C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
- C30B29/00—Single crystals or homogeneous polycrystalline material with defined structure characterised by the material or by their shape
- C30B29/54—Organic compounds
- C30B29/58—Macromolecular compounds
-
- C—CHEMISTRY; METALLURGY
- C30—CRYSTAL GROWTH
- C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
- C30B7/00—Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions
- C30B7/02—Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions by evaporation of the solvent
-
- G—PHYSICS
- G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
- G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
- G16B15/00—ICT specially adapted for analysing two-dimensional or three-dimensional molecular structures, e.g. structural or functional relations or structure alignment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Physics & Mathematics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Evolutionary Biology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Medical Informatics (AREA)
- Theoretical Computer Science (AREA)
- Materials Engineering (AREA)
- Metallurgy (AREA)
- Pharmacology & Pharmacy (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
La présente invention concerne des analogues de l'insuline, en particulier des analogues de l'insuline présentant des chaînes B raccourcies. La présente invention concerne également la structure cristalline de l'insuline provenant du venin d'escargots marins, ainsi que des procédés d'utilisation du cristal et des informations structurales associées pour cribler et concevoir des analogues d'insuline qui interagissent avec ou modulent le récepteur de l'insuline. La présente invention concerne également des procédés thérapeutiques et prophylactiques utilisant les analogues de l'insuline.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2016902883A AU2016902883A0 (en) | 2016-07-22 | Insulin Analogs | |
AU2016902883 | 2016-07-22 | ||
US201762483118P | 2017-04-07 | 2017-04-07 | |
US62/483,118 | 2017-04-07 | ||
PCT/AU2017/050758 WO2018014091A1 (fr) | 2016-07-22 | 2017-07-21 | Analogues de l'insuline |
Publications (1)
Publication Number | Publication Date |
---|---|
CA3030930A1 true CA3030930A1 (fr) | 2018-01-25 |
Family
ID=60991677
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA3030930A Pending CA3030930A1 (fr) | 2016-07-22 | 2017-07-21 | Analogues de l'insuline |
Country Status (3)
Country | Link |
---|---|
AU (1) | AU2017298565B2 (fr) |
CA (1) | CA3030930A1 (fr) |
WO (1) | WO2018014091A1 (fr) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3481945A4 (fr) | 2016-07-11 | 2020-07-29 | Board of Regents, The University of Texas System | Polypeptides de recombinaison comprenant de la sélénocystéine et leur procédé de production |
MA45727A (fr) | 2016-07-22 | 2019-05-29 | Walter & Eliza Hall Inst Medical Res | Analogues de l'insuline |
JP7186400B2 (ja) | 2016-08-30 | 2022-12-09 | ボード オブ リージェンツ,ザ ユニバーシティ オブ テキサス システム | ゲノム的に再コードした生物におけるセレノ-生物製剤の製造 |
WO2018187568A1 (fr) * | 2017-04-07 | 2018-10-11 | University Of Utah Research Foundation | Analogues d'insuline et procédés d'utilisation |
LT3892628T (lt) * | 2018-06-29 | 2022-12-12 | Akston Biosciences Corporation | Itin ilgai veikiantys insulino-fc sulieti baltymai ir naudojimo būdai |
CN114675019B (zh) * | 2022-02-10 | 2022-12-16 | 江苏省人民医院(南京医科大学第一附属医院) | 一种检测胰岛素受体胞外段抗体的试剂盒 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005095443A1 (fr) * | 2004-03-31 | 2005-10-13 | Cardio Incorporated | Système d'administration médicamenteuse utilisant un peptide modifié |
US7790677B2 (en) * | 2006-12-13 | 2010-09-07 | Elona Biotechnologies | Insulin production methods and pro-insulin constructs |
CN103889443A (zh) * | 2011-06-17 | 2014-06-25 | 哈洛齐梅公司 | 使用透明质酸降解酶的持续皮下胰岛素输注法 |
-
2017
- 2017-07-21 CA CA3030930A patent/CA3030930A1/fr active Pending
- 2017-07-21 AU AU2017298565A patent/AU2017298565B2/en active Active
- 2017-07-21 WO PCT/AU2017/050758 patent/WO2018014091A1/fr unknown
Also Published As
Publication number | Publication date |
---|---|
AU2017298565B2 (en) | 2021-08-19 |
AU2017298565A1 (en) | 2019-02-21 |
WO2018014091A1 (fr) | 2018-01-25 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request |
Effective date: 20220505 |
|
EEER | Examination request |
Effective date: 20220505 |
|
EEER | Examination request |
Effective date: 20220505 |
|
EEER | Examination request |
Effective date: 20220505 |
|
EEER | Examination request |
Effective date: 20220505 |