CA3029781A1 - Methods and compositions for the treatment of cancer - Google Patents
Methods and compositions for the treatment of cancer Download PDFInfo
- Publication number
- CA3029781A1 CA3029781A1 CA3029781A CA3029781A CA3029781A1 CA 3029781 A1 CA3029781 A1 CA 3029781A1 CA 3029781 A CA3029781 A CA 3029781A CA 3029781 A CA3029781 A CA 3029781A CA 3029781 A1 CA3029781 A1 CA 3029781A1
- Authority
- CA
- Canada
- Prior art keywords
- polypeptide
- seq
- equivalent variant
- residue
- cell
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
- C07K14/4703—Inhibitors; Suppressors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
- A61K47/6445—Haemoglobin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/82—Translation products from oncogenes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/09—Fusion polypeptide containing a localisation/targetting motif containing a nuclear localisation signal
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/10—Fusion polypeptide containing a localisation/targetting motif containing a tag for extracellular membrane crossing, e.g. TAT or VP22
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Epidemiology (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16382339.6A EP3269734A1 (en) | 2016-07-15 | 2016-07-15 | Methods and compositions for the treatment of cancer |
| EP16382339.6 | 2016-07-15 | ||
| PCT/EP2017/067998 WO2018011433A1 (en) | 2016-07-15 | 2017-07-17 | Methods and compositions for the treatment of cancer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA3029781A1 true CA3029781A1 (en) | 2018-01-18 |
| CA3029781C CA3029781C (en) | 2025-09-23 |
Family
ID=
Also Published As
| Publication number | Publication date |
|---|---|
| US20200247857A1 (en) | 2020-08-06 |
| ZA201900960B (en) | 2020-05-27 |
| AU2017295071B2 (en) | 2022-06-09 |
| MX2019000346A (es) | 2019-04-01 |
| IL264176B2 (en) | 2023-07-01 |
| EP3484913B1 (en) | 2024-07-03 |
| WO2018011433A1 (en) | 2018-01-18 |
| CN109563151A (zh) | 2019-04-02 |
| IL264176A (en) | 2019-02-28 |
| RS65983B1 (sr) | 2024-10-31 |
| MA45675B1 (fr) | 2024-07-31 |
| SMT202400360T1 (it) | 2024-11-15 |
| JP2019525753A (ja) | 2019-09-12 |
| ES2985967T3 (es) | 2024-11-08 |
| IL264176B1 (en) | 2023-03-01 |
| PL3484913T3 (pl) | 2025-01-07 |
| EA201990298A1 (ru) | 2019-06-28 |
| JP7090593B2 (ja) | 2022-06-24 |
| AU2017295071A1 (en) | 2019-01-31 |
| KR20190032427A (ko) | 2019-03-27 |
| BR112019000732A2 (pt) | 2019-07-30 |
| MA45675A (fr) | 2021-04-21 |
| SG11201900021PA (en) | 2019-01-30 |
| CN109563151B (zh) | 2023-03-07 |
| HUE067973T2 (hu) | 2024-11-28 |
| US11427621B2 (en) | 2022-08-30 |
| MD3484913T2 (ro) | 2024-10-31 |
| KR102232500B1 (ko) | 2021-03-26 |
| HRP20241153T1 (hr) | 2024-11-22 |
| EP3269734A1 (en) | 2018-01-17 |
| EP3484913C0 (en) | 2024-07-03 |
| EP3484913A1 (en) | 2019-05-22 |
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| US11427621B2 (en) | Methods and compositions for the treatment of cancer | |
| US11339205B2 (en) | Methods and compositions for the treatment of cancer | |
| CA3029781C (en) | Methods and compositions for the treatment of cancer | |
| HK40007694B (en) | Methods and compositions for the treatment of cancer | |
| HK40007694A (en) | Methods and compositions for the treatment of cancer | |
| EA042570B1 (ru) | Способы и композиции для лечения рака | |
| HK40014958A (en) | Methods and compositions for the treatment of cancer | |
| HK1219756B (en) | Methods and compositions for the treatment of cancer | |
| EA047076B1 (ru) | Способы и композиции для лечения рака |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20220308 |
|
| EEER | Examination request |
Effective date: 20220308 |
|
| EEER | Examination request |
Effective date: 20220308 |
|
| EEER | Examination request |
Effective date: 20220308 |
|
| EEER | Examination request |
Effective date: 20220308 |
|
| EEER | Examination request |
Effective date: 20220308 |
|
| EEER | Examination request |
Effective date: 20220308 |