CA3024123A1 - Combination of anti-cd20 antibody, p13 kinase-delta selective inhibitor, and btk inhibitor to treat b-cell proliferative disorders - Google Patents
Combination of anti-cd20 antibody, p13 kinase-delta selective inhibitor, and btk inhibitor to treat b-cell proliferative disorders Download PDFInfo
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- CA3024123A1 CA3024123A1 CA3024123A CA3024123A CA3024123A1 CA 3024123 A1 CA3024123 A1 CA 3024123A1 CA 3024123 A CA3024123 A CA 3024123A CA 3024123 A CA3024123 A CA 3024123A CA 3024123 A1 CA3024123 A1 CA 3024123A1
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- Prior art keywords
- lymphoma
- antibody
- cell
- inhibitor
- agents
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- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
Landscapes
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- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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| US201662342822P | 2016-05-27 | 2016-05-27 | |
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| PCT/US2017/034855 WO2017205843A1 (en) | 2016-05-27 | 2017-05-26 | Combination of anti-cd20 antibody, p13 kinase-delta selective inhibitor, and btk inhibitor to treat b-cell proliferative disorders |
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| MD3892302T2 (ro) | 2015-04-06 | 2024-03-31 | Janssen Pharmaceutica Nv | Compoziții care conțin Ibrutinib |
| TW201924721A (zh) * | 2017-12-08 | 2019-07-01 | 韓商保寧製藥股份公司 | 包含pi3激酶抑制劑與bcl-2抑制劑的組成物 |
| US12133884B2 (en) | 2018-05-11 | 2024-11-05 | Beam Therapeutics Inc. | Methods of substituting pathogenic amino acids using programmable base editor systems |
| KR102844084B1 (ko) * | 2018-06-15 | 2025-08-07 | 얀센 파마슈티카 엔브이 | 이브루티닙을 포함하는 제형/조성물 |
| CN108743947B (zh) * | 2018-07-04 | 2020-12-15 | 复旦大学附属肿瘤医院 | 一种治疗b细胞淋巴瘤的药物组合物 |
| US20220251091A1 (en) * | 2019-07-15 | 2022-08-11 | Johnson Matthey Public Limited Company | Amorphous umbralisib monotosylate |
| US20220143026A1 (en) | 2020-11-12 | 2022-05-12 | Tg Therapeutics, Inc. | Triple combination to treat b-cell malignancies |
| KR20240024048A (ko) * | 2021-04-08 | 2024-02-23 | 아티바 바이오테라퓨틱스, 인크. | Nk 세포와 her2 표적 항체를 이용한 암 치료 방법 |
| US11965032B1 (en) | 2022-06-01 | 2024-04-23 | Tg Therapeutics, Inc. | Anti-CD20 antibody compositions |
| US11884740B1 (en) | 2022-06-01 | 2024-01-30 | Tg Therapeutics, Inc. | Anti-CD20 antibody compositions |
| US11807689B1 (en) | 2022-06-01 | 2023-11-07 | Tg Therapeutics, Inc. | Anti-CD20 antibody compositions |
| US11814439B1 (en) | 2022-06-01 | 2023-11-14 | Tg Therapeutics, Inc. | Anti-CD20 antibody compositions |
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| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5639641A (en) | 1992-09-09 | 1997-06-17 | Immunogen Inc. | Resurfacing of rodent antibodies |
| US5736137A (en) | 1992-11-13 | 1998-04-07 | Idec Pharmaceuticals Corporation | Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma |
| US6326469B1 (en) | 1994-04-22 | 2001-12-04 | Sugen, Inc. | Megakaryocytic protein tyrosine kinases |
| AU8619698A (en) | 1997-07-25 | 1999-02-16 | Ban C. H. Tsui | Devices, systems and methods for determining proper placement of epidural catheters |
| FR2807767B1 (fr) | 2000-04-12 | 2005-01-14 | Lab Francais Du Fractionnement | Anticorps monoclonaux anti-d |
| FR2844455B1 (fr) | 2002-09-13 | 2007-12-14 | Lab Francais Du Fractionnement | Traitement des pathologies echappant a la reponse immune par des anticorps optimises |
| ES2347241T3 (es) | 2002-12-16 | 2010-10-27 | Genentech, Inc. | Variantes de inmunoglobulina y sus utilizaciones. |
| FR2858235B1 (fr) | 2003-07-31 | 2006-02-17 | Lab Francais Du Fractionnement | Utilisation d'anticorps optimises en adcc pour traiter les patients faibles repondeurs |
| US7663057B2 (en) | 2004-02-19 | 2010-02-16 | Nanosolar, Inc. | Solution-based fabrication of photovoltaic cell |
| FR2879204B1 (fr) | 2004-12-15 | 2007-02-16 | Lab Francais Du Fractionnement | Anticorps cytotoxique dirige contre les proliferations hematopoietiques lymphoides de type b. |
| US8543180B2 (en) | 2006-05-03 | 2013-09-24 | Covidien Lp | Method and apparatus for total hemoglobin measurement |
| SG166093A1 (en) | 2006-09-22 | 2010-11-29 | Pharmacyclics Inc | Inhibitors of brutonæs tyrosine kinase |
| JP5889795B2 (ja) | 2009-11-05 | 2016-03-22 | ライゼン・ファーマシューティカルズ・エスアー | 新規キナーゼモジュレーター |
| KR102216606B1 (ko) | 2012-07-04 | 2021-02-17 | 리젠 파마슈티컬스 소시에떼 아노님 | 선택적 pi3k 델타 억제제 |
| CN105073197B (zh) | 2012-11-02 | 2019-06-28 | Tg疗法有限公司 | 抗cd20抗体和pi3激酶选择性抑制剂的组合 |
| US10272083B2 (en) | 2014-01-21 | 2019-04-30 | Acerta Pharma B.V. | Methods of treating chronic lymphocytic leukemia and small lymphocytic leukemia using a BTK inhibitor |
| CA2942528A1 (en) | 2014-03-20 | 2015-09-24 | Pharmacyclics Inc. | Phospholipase c gamma 2 and resistance associated mutations |
| KR20170007480A (ko) | 2014-05-27 | 2017-01-18 | 리젠 파마슈티컬스 소시에떼 아노님 | 약제학적 제형에 사용하기 위한 pi3k 델타 선택적 억제제의 개선된 형태 |
| WO2016022853A1 (en) | 2014-08-08 | 2016-02-11 | Pharmacyclics Llc | Bruton's tyrosine kinase inhibitor combinations and uses thereof |
| US20170224819A1 (en) * | 2014-08-11 | 2017-08-10 | Acerta Pharma B.V. | Therapeutic Combinations of a BTK Inhibitor, a PI3K Inhibitor, a JAK-2 Inhibitor, and/or a CDK 4/6 Inhibitor |
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| US20210169878A1 (en) | 2021-06-10 |
| IL263239A (en) | 2018-12-31 |
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| US10966977B2 (en) | 2021-04-06 |
| CL2018003349A1 (es) | 2019-03-15 |
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| MX2018014577A (es) | 2019-05-20 |
| EP3463318A1 (en) | 2019-04-10 |
| JP2019517485A (ja) | 2019-06-24 |
| AU2017268839A1 (en) | 2018-11-29 |
| WO2017205843A1 (en) | 2017-11-30 |
| CN109640964A (zh) | 2019-04-16 |
| SG11201810333UA (en) | 2018-12-28 |
| EP3463318A4 (en) | 2020-01-01 |
| EA201892284A1 (ru) | 2019-08-30 |
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Effective date: 20230823 |