CA3023662A1 - Process for synthesizing 2-hydroxy-6-((2-(1-isopropyl-1h-pyrazol-5-yl)-pyridin-3-yl)methoxy)benzaldehyde - Google Patents

Process for synthesizing 2-hydroxy-6-((2-(1-isopropyl-1h-pyrazol-5-yl)-pyridin-3-yl)methoxy)benzaldehyde Download PDF

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CA3023662A1
CA3023662A1 CA3023662A CA3023662A CA3023662A1 CA 3023662 A1 CA3023662 A1 CA 3023662A1 CA 3023662 A CA3023662 A CA 3023662A CA 3023662 A CA3023662 A CA 3023662A CA 3023662 A1 CA3023662 A1 CA 3023662A1
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compound
alkyl
formula
acid
hydrogen
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CA3023662A
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English (en)
French (fr)
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CA3023662C (en
Inventor
Zhe Li
Nathan GUZ
Yiyang SHAO
Julieana COCUZ
Markus Frieser
George Petros Yiannikouros
Liang LIAO
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Global Blood Therapeutics Inc
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Global Blood Therapeutics Inc
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/65Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by splitting-off hydrogen atoms or functional groups; by hydrogenolysis of functional groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00Compounds having —CHO groups
    • C07C47/52Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
    • C07C47/56Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing hydroxy groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00Compounds having —CHO groups
    • C07C47/52Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
    • C07C47/56Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing hydroxy groups
    • C07C47/565Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing hydroxy groups all hydroxy groups bound to the ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00Compounds having —CHO groups
    • C07C47/52Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings
    • C07C47/575Compounds having —CHO groups bound to carbon atoms of six—membered aromatic rings containing ether groups, groups, groups, or groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pyridine Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA3023662A 2016-05-12 2017-05-11 Process for synthesizing 2-hydroxy-6-((2-(1-isopropyl-1h-pyrazol-5-yl)-pyridin-3-yl)methoxy)benzaldehyde Active CA3023662C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662335583P 2016-05-12 2016-05-12
US62/335,583 2016-05-12
PCT/US2017/032104 WO2017197083A1 (en) 2016-05-12 2017-05-11 Process for synthesizing 2-hydroxy-6-((2-(1-isopropyl-1h-pyrazol-5-yl)-pyridin-3-yl)methoxy)benzaldehyde

Publications (2)

Publication Number Publication Date
CA3023662A1 true CA3023662A1 (en) 2017-11-16
CA3023662C CA3023662C (en) 2024-07-02

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Publication number Publication date
EP3454854B1 (en) 2021-04-28
MX2021012669A (es) 2022-08-10
JP2022088564A (ja) 2022-06-14
EA202092636A1 (ru) 2021-09-30
PL3454854T3 (pl) 2021-11-29
US20220135533A1 (en) 2022-05-05
BR112018072351A2 (pt) 2019-02-19
EP3909941A1 (en) 2021-11-17
TWI825524B (zh) 2023-12-11
AU2021200802A1 (en) 2021-03-04
IL262791A (en) 2018-12-31
IL284406B2 (en) 2023-03-01
EA037014B1 (ru) 2021-01-26
KR20220139437A (ko) 2022-10-14
WO2017197083A1 (en) 2017-11-16
IL284406B (en) 2022-11-01
US20190106404A1 (en) 2019-04-11
AR108435A1 (es) 2018-08-22
HUE055045T2 (hu) 2021-10-28
ES2881426T3 (es) 2021-11-29
KR20230146119A (ko) 2023-10-18
TWI663160B (zh) 2019-06-21
DK3454854T3 (da) 2021-08-02
CN109152770A (zh) 2019-01-04
EP3454854A1 (en) 2019-03-20
TWI752307B (zh) 2022-01-11
US10077249B2 (en) 2018-09-18
MX377901B (es) 2025-03-10
US20170327484A1 (en) 2017-11-16
EA201892151A1 (ru) 2019-06-28
IL262791B (en) 2021-07-29
MX2018013099A (es) 2019-03-28
KR102487509B1 (ko) 2023-01-12
EP3454854A4 (en) 2019-12-11
JP7398193B2 (ja) 2023-12-14
JP2019516692A (ja) 2019-06-20
TW202237575A (zh) 2022-10-01
PT3454854T (pt) 2021-07-30
US10577345B2 (en) 2020-03-03
CN115819400A (zh) 2023-03-21
IL297055B1 (en) 2023-12-01
US20230219922A1 (en) 2023-07-13
AU2021200802B2 (en) 2022-09-29
TW201932440A (zh) 2019-08-16
US20210284623A1 (en) 2021-09-16
KR20190005917A (ko) 2019-01-16
SG11201809344QA (en) 2018-11-29
HRP20211193T1 (hr) 2021-10-29
IL297055A (en) 2022-12-01
TW201741295A (zh) 2017-12-01
SG10201912288VA (en) 2020-02-27
AU2017261730A1 (en) 2018-11-15
MX387149B (es) 2025-03-18
IL297055B2 (en) 2024-04-01
MX2020013114A (es) 2021-10-18
IL284406A (en) 2021-07-29
AU2017261730B2 (en) 2020-11-19

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