CA3021609A1 - A microfluidic chip for focussing a stream of particulate containing fluid - Google Patents
A microfluidic chip for focussing a stream of particulate containing fluid Download PDFInfo
- Publication number
- CA3021609A1 CA3021609A1 CA3021609A CA3021609A CA3021609A1 CA 3021609 A1 CA3021609 A1 CA 3021609A1 CA 3021609 A CA3021609 A CA 3021609A CA 3021609 A CA3021609 A CA 3021609A CA 3021609 A1 CA3021609 A1 CA 3021609A1
- Authority
- CA
- Canada
- Prior art keywords
- channel
- microfluidic
- guidance
- fluid
- microfluidic channel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
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Classifications
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- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
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- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502769—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements
- B01L3/502776—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by multiphase flow arrangements specially adapted for focusing or laminating flows
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- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502746—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles
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- B—PERFORMING OPERATIONS; TRANSPORTING
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- B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
- C12M47/04—Cell isolation or sorting
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- G01N15/14—Optical investigation techniques, e.g. flow cytometry
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- G01N15/1459—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals the analysis being performed on a sample stream
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- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
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- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1484—Optical investigation techniques, e.g. flow cytometry microstructural devices
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0636—Focussing flows, e.g. to laminate flows
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- B—PERFORMING OPERATIONS; TRANSPORTING
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- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
- B01L2200/0652—Sorting or classification of particles or molecules
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0627—Sensor or part of a sensor is integrated
- B01L2300/0645—Electrodes
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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- B01L2300/00—Additional constructional details
- B01L2300/06—Auxiliary integrated devices, integrated components
- B01L2300/0627—Sensor or part of a sensor is integrated
- B01L2300/0663—Whole sensors
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
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- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0463—Hydrodynamic forces, venturi nozzles
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/04—Moving fluids with specific forces or mechanical means
- B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
- B01L2400/0469—Buoyancy
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N2015/0038—Investigating nanoparticles
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N2015/0042—Investigating dispersion of solids
- G01N2015/0053—Investigating dispersion of solids in liquids, e.g. trouble
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N2015/1006—Investigating individual particles for cytology
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
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- G01N2015/1402—Data analysis by thresholding or gating operations performed on the acquired signals or stored data
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- G—PHYSICS
- G01—MEASURING; TESTING
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- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
- G01N15/14—Optical investigation techniques, e.g. flow cytometry
- G01N15/1404—Handling flow, e.g. hydrodynamic focusing
- G01N2015/1413—Hydrodynamic focussing
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Dispersion Chemistry (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- General Physics & Mathematics (AREA)
- Clinical Laboratory Science (AREA)
- Hematology (AREA)
- Organic Chemistry (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Cell Biology (AREA)
- Fluid Mechanics (AREA)
- General Engineering & Computer Science (AREA)
- Sustainable Development (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Micromachines (AREA)
- Optical Measuring Cells (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP16166177.2 | 2016-04-20 | ||
| EP16166177 | 2016-04-20 | ||
| PCT/EP2017/059453 WO2017182599A1 (en) | 2016-04-20 | 2017-04-20 | A microfluidic chip for focussing a stream of particulate containing fluid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3021609A1 true CA3021609A1 (en) | 2017-10-26 |
Family
ID=55794906
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3021609A Abandoned CA3021609A1 (en) | 2016-04-20 | 2017-04-20 | A microfluidic chip for focussing a stream of particulate containing fluid |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US11633737B2 (enExample) |
| EP (1) | EP3445492B1 (enExample) |
| JP (1) | JP2019518971A (enExample) |
| CN (1) | CN109689212A (enExample) |
| AU (1) | AU2017251990A1 (enExample) |
| BR (1) | BR112018071562A2 (enExample) |
| CA (1) | CA3021609A1 (enExample) |
| MX (1) | MX2018012862A (enExample) |
| RU (1) | RU2018136932A (enExample) |
| WO (1) | WO2017182599A1 (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3556845A1 (en) | 2018-04-20 | 2019-10-23 | Cellix Limited | A method and device for transfecting cells |
| EP3946733B1 (en) | 2019-03-29 | 2024-05-08 | Cellix Limited | A method and device for transfecting cells |
| CA3097579A1 (en) | 2019-10-28 | 2021-04-28 | Op-Hygiene Ip Gmbh | Method of identifying biologic particles |
| CN111135882B (zh) * | 2019-12-30 | 2021-07-09 | 南方科技大学 | 一种二维流动聚焦装置 |
| EP3871773B1 (en) | 2020-02-27 | 2025-12-10 | Cellix Limited | A method of determining the transfection status of a plurality of cells |
| US20230408395A1 (en) * | 2020-11-20 | 2023-12-21 | The Trustees Of Princeton University | System and method for pneumatic-free electronically driven microfluidics to allow massive scalability with integrated cellular and biomolecular detection |
| CN112698024B (zh) * | 2020-12-08 | 2022-04-26 | 华中农业大学 | 一种基于差分阻抗颗粒计数的免疫分析方法 |
| EP4308902A4 (en) * | 2021-03-18 | 2025-01-22 | Nanyang Technological University | Method for label-free cell activation profiling using microfluidic impedance cytometry |
| CN114112826B (zh) * | 2021-11-25 | 2024-04-19 | 天津大学 | 用于荧光微粒的声光互联微流控检测系统和检测方法 |
| EP4465016A4 (en) * | 2022-03-14 | 2025-11-26 | Orange Biomed Co Ltd | METHOD FOR MEASURING PARTICLES IN SOLUTION AND DEVICE FOR ITS IMPLEMENTATION |
| CN120082423B (zh) * | 2025-05-06 | 2025-09-12 | 杭州谱康医学科技有限公司 | 微粒分选装置和方法 |
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| US5716852A (en) * | 1996-03-29 | 1998-02-10 | University Of Washington | Microfabricated diffusion-based chemical sensor |
| US6437551B1 (en) * | 1999-11-02 | 2002-08-20 | The Regents Of The University Of California | Microfabricated AC impedance sensor |
| JP4093740B2 (ja) | 2001-09-27 | 2008-06-04 | 独立行政法人科学技術振興機構 | 微粒子分別マイクロチップと微粒子分別装置 |
| US6703819B2 (en) * | 2001-12-03 | 2004-03-09 | Board Of Regents, The University Of Texas System | Particle impedance sensor |
| GB2383127B (en) * | 2001-12-12 | 2004-10-20 | Proimmune Ltd | Device and method for investigating analytes in liquid suspension or solution |
| AU2003216175A1 (en) * | 2002-02-04 | 2003-09-02 | Colorado School Of Mines | Laminar flow-based separations of colloidal and cellular particles |
| DE102007017318B4 (de) | 2007-04-11 | 2014-07-31 | Bundesrepublik Deutschland, vertreten durch das Bundesministerium für Wirtschaft und Technologie, dieses vertreten durch den Präsidenten der Physikalisch-Technischen Bundesanstalt | Verfahren zum hydrodynamischen Fokussieren eines Fluidstroms und Anordnung |
| JP4661942B2 (ja) | 2008-05-13 | 2011-03-30 | ソニー株式会社 | マイクロチップとその流路構造 |
| US8693762B2 (en) | 2010-09-14 | 2014-04-08 | The Regents Of The University Of California | Inertial particle focusing flow cytometer |
| US9170138B2 (en) * | 2010-10-01 | 2015-10-27 | The Board Of Trustees Of The Leland Stanford Junior University | Enhanced microfluidic electromagnetic measurements |
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- 2017-04-20 BR BR112018071562-0A patent/BR112018071562A2/pt not_active Application Discontinuation
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- 2017-04-20 JP JP2019506540A patent/JP2019518971A/ja not_active Withdrawn
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| AU2017251990A1 (en) | 2018-11-15 |
| US11633737B2 (en) | 2023-04-25 |
| US20190232290A1 (en) | 2019-08-01 |
| RU2018136932A (ru) | 2020-05-20 |
| EP3445492A1 (en) | 2019-02-27 |
| RU2018136932A3 (enExample) | 2020-09-07 |
| BR112018071562A2 (pt) | 2019-02-12 |
| JP2019518971A (ja) | 2019-07-04 |
| MX2018012862A (es) | 2019-07-04 |
| EP3445492B1 (en) | 2021-09-15 |
| CN109689212A (zh) | 2019-04-26 |
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