CA3018776A1 - Compositions et methodes pour determiner la presence de cellules leucocytaires actives au moyen d'une analyse electrochimique - Google Patents
Compositions et methodes pour determiner la presence de cellules leucocytaires actives au moyen d'une analyse electrochimique Download PDFInfo
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- CA3018776A1 CA3018776A1 CA3018776A CA3018776A CA3018776A1 CA 3018776 A1 CA3018776 A1 CA 3018776A1 CA 3018776 A CA3018776 A CA 3018776A CA 3018776 A CA3018776 A CA 3018776A CA 3018776 A1 CA3018776 A1 CA 3018776A1
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- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
- C07C311/19—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C309/29—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings
- C07C309/30—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings of six-membered aromatic rings substituted by alkyl groups
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
- C07K5/1008—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
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- C—CHEMISTRY; METALLURGY
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- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
- C12Q1/44—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving esterase
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- G—PHYSICS
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/50—Determining the risk of developing a disease
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
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Abstract
La présente invention concerne des compositions, des méthodes et des dispositifs d'essai pour déterminer la présence de cellules leucocytaires actives, par exemple, au moyen de nouveaux substrats LE et/ou HNE dans une analyse électrochimique.
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662311405P | 2016-03-22 | 2016-03-22 | |
| US62/311,405 | 2016-03-22 | ||
| US201662352560P | 2016-06-21 | 2016-06-21 | |
| US62/352,560 | 2016-06-21 | ||
| PCT/US2017/022976 WO2017165222A1 (fr) | 2016-03-22 | 2017-03-17 | Compositions et méthodes pour déterminer la présence de cellules leucocytaires actives au moyen d'une analyse électrochimique |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3018776A1 true CA3018776A1 (fr) | 2017-09-28 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3018776A Pending CA3018776A1 (fr) | 2016-03-22 | 2017-03-17 | Compositions et methodes pour determiner la presence de cellules leucocytaires actives au moyen d'une analyse electrochimique |
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| Country | Link |
|---|---|
| EP (1) | EP3432873A4 (fr) |
| JP (1) | JP2019515681A (fr) |
| CA (1) | CA3018776A1 (fr) |
| WO (1) | WO2017165222A1 (fr) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11104933B1 (en) | 2016-03-22 | 2021-08-31 | Cleu Diagnostics, Llc | Compositions and methods for determining the presence of active leukocyte cells using an electrochemical assay |
| US11492331B2 (en) | 2017-11-08 | 2022-11-08 | The Board Of Regents Of The University Of Texas System | Redox substrates for leukocyte esterase |
| WO2022148866A1 (fr) | 2021-01-08 | 2022-07-14 | Alpspitz Bioscience Gmbh | Utilisation de biomarqueurs pour prédire le résultat clinique et/ou thérapeutique chez un sujet humain |
Family Cites Families (13)
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| DE3104078C2 (de) * | 1981-02-06 | 1983-07-21 | Max Planck Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen | Verfahren zur Bestimmung des pH-Wertes im Innern einer Zelle; 1,4-Dibutyryloxy-2,3-dicyanobenzol; 1,4-Di(-tert-butyloxycarbonyl-l-alanyloxy)-2-3-dicyanobenzol |
| US4897444A (en) * | 1985-05-31 | 1990-01-30 | The Research Foundation Of The State University Of New York | Immobilized fluorogenic substrates for enzymes; and processes for their preparation |
| JPH03244396A (ja) * | 1990-02-23 | 1991-10-31 | Terumo Corp | 加水分解酵素の検出方法およびそれに使用する検出器具 |
| US5464739A (en) * | 1994-08-22 | 1995-11-07 | Bayer Corporation | Composition method for determining the presence of leukocyte cells, esterase or protease in a test sample |
| CA2161574A1 (fr) * | 1994-11-15 | 1996-05-16 | James Noffsinger | Methode pour determiner par colorimetrie la concentration des leucocytes dans un fluide biologique |
| US6893868B2 (en) * | 1997-02-20 | 2005-05-17 | Onco Immunin, Inc. | Homo-doubly labeled compositions for the detection of enzyme activity in biological samples |
| DE19829707C2 (de) * | 1998-07-03 | 2002-07-18 | Macherey Nagel Gmbh & Co Hg | Diagnostisches Mittel zum Nachweis von Leukozyten, Elastasen, Esterasen und Proteasen |
| US6348324B1 (en) * | 1999-01-21 | 2002-02-19 | Hypoguard America Limited | Composition and device for detecting leukocytes in urine |
| AU2002363939A1 (en) * | 2001-11-20 | 2003-06-10 | Seattle Genetics, Inc. | Treatment of immunological disorders using anti-cd30 antibodies |
| US20100226931A1 (en) * | 2004-06-24 | 2010-09-09 | Nicholas Valiante | Compounds for immunopotentiation |
| CN102170872B (zh) * | 2007-12-19 | 2014-08-27 | 港大科桥有限公司 | 调节细胞膜电位的方法 |
| WO2010036930A1 (fr) | 2008-09-26 | 2010-04-01 | Javad Parvizi | Méthodes et trousses de détection d'une infection articulaire |
| WO2014165618A1 (fr) | 2013-04-02 | 2014-10-09 | Board Of Regents, The University Of Texas System | Quantification rapide de l'activité enzymatique par électroanalyse |
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2017
- 2017-03-17 EP EP17770862.5A patent/EP3432873A4/fr active Pending
- 2017-03-17 WO PCT/US2017/022976 patent/WO2017165222A1/fr active Application Filing
- 2017-03-17 JP JP2019500736A patent/JP2019515681A/ja active Pending
- 2017-03-17 CA CA3018776A patent/CA3018776A1/fr active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| EP3432873A1 (fr) | 2019-01-30 |
| EP3432873A4 (fr) | 2020-01-08 |
| JP2019515681A (ja) | 2019-06-13 |
| WO2017165222A1 (fr) | 2017-09-28 |
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