CA3018429A1 - Degradation of cyclin-dependent kinase 9 (cdk9) by conjugation of cdk9 inhibitors with e3 ligase ligand and methods of use - Google Patents

Degradation of cyclin-dependent kinase 9 (cdk9) by conjugation of cdk9 inhibitors with e3 ligase ligand and methods of use Download PDF

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Publication number
CA3018429A1
CA3018429A1 CA3018429A CA3018429A CA3018429A1 CA 3018429 A1 CA3018429 A1 CA 3018429A1 CA 3018429 A CA3018429 A CA 3018429A CA 3018429 A CA3018429 A CA 3018429A CA 3018429 A1 CA3018429 A1 CA 3018429A1
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Prior art keywords
cancer
disease
bifunctional compound
cdk9
alkyl
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CA3018429A
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English (en)
French (fr)
Inventor
Nathanael Gray
Tinghu Zhang
Calla M. OLSON
Yanke LIANG
Nicholas KWIATKOWSKI
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Dana Farber Cancer Institute Inc
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Dana Farber Cancer Institute Inc
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Publication of CA3018429A1 publication Critical patent/CA3018429A1/en
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CA3018429A 2016-04-22 2017-04-21 Degradation of cyclin-dependent kinase 9 (cdk9) by conjugation of cdk9 inhibitors with e3 ligase ligand and methods of use Pending CA3018429A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662326581P 2016-04-22 2016-04-22
US62/326,581 2016-04-22
PCT/US2017/028924 WO2017185023A1 (en) 2016-04-22 2017-04-21 Degradation of cyclin-dependent kinase 9 (cdk9) by conjugation of cdk9 inhibitors with e3 ligase ligand and methods of use

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CA3018429A1 true CA3018429A1 (en) 2017-10-26

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US (1) US10532103B2 (enExample)
EP (1) EP3445760B1 (enExample)
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CN (1) CN109153675B (enExample)
AU (1) AU2017254702B2 (enExample)
CA (1) CA3018429A1 (enExample)
WO (1) WO2017185023A1 (enExample)

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US11110177B2 (en) 2017-11-10 2021-09-07 The Regents Of The University Of Michigan ASH1L degraders and methods of treatment therewith
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