CA3018429A1 - Degradation of cyclin-dependent kinase 9 (cdk9) by conjugation of cdk9 inhibitors with e3 ligase ligand and methods of use - Google Patents

Degradation of cyclin-dependent kinase 9 (cdk9) by conjugation of cdk9 inhibitors with e3 ligase ligand and methods of use Download PDF

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Publication number
CA3018429A1
CA3018429A1 CA3018429A CA3018429A CA3018429A1 CA 3018429 A1 CA3018429 A1 CA 3018429A1 CA 3018429 A CA3018429 A CA 3018429A CA 3018429 A CA3018429 A CA 3018429A CA 3018429 A1 CA3018429 A1 CA 3018429A1
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Prior art keywords
cancer
disease
bifunctional compound
cdk9
alkyl
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CA3018429A
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English (en)
French (fr)
Inventor
Nathanael Gray
Tinghu Zhang
Calla M. OLSON
Yanke LIANG
Nicholas KWIATKOWSKI
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Dana Farber Cancer Institute Inc
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Dana Farber Cancer Institute Inc
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Publication of CA3018429A1 publication Critical patent/CA3018429A1/en
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CA3018429A 2016-04-22 2017-04-21 Degradation of cyclin-dependent kinase 9 (cdk9) by conjugation of cdk9 inhibitors with e3 ligase ligand and methods of use Pending CA3018429A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662326581P 2016-04-22 2016-04-22
US62/326,581 2016-04-22
PCT/US2017/028924 WO2017185023A1 (en) 2016-04-22 2017-04-21 Degradation of cyclin-dependent kinase 9 (cdk9) by conjugation of cdk9 inhibitors with e3 ligase ligand and methods of use

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CA3018429A1 true CA3018429A1 (en) 2017-10-26

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US (1) US10532103B2 (OSRAM)
EP (1) EP3445760B1 (OSRAM)
JP (1) JP6927999B2 (OSRAM)
CN (1) CN109153675B (OSRAM)
AU (1) AU2017254702B2 (OSRAM)
CA (1) CA3018429A1 (OSRAM)
WO (1) WO2017185023A1 (OSRAM)

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US11173211B2 (en) 2016-12-23 2021-11-16 Arvinas Operations, Inc. Compounds and methods for the targeted degradation of rapidly accelerated Fibrosarcoma polypeptides
US10513515B2 (en) 2017-08-25 2019-12-24 Biotheryx, Inc. Ether compounds and uses thereof
WO2019094772A1 (en) 2017-11-10 2019-05-16 The Regents Of The University Of Michigan Ash1l degraders and methods of treatment therewith
CA3088561A1 (en) * 2018-02-20 2019-08-29 Dana-Farber Cancer Institute, Inc. Degraders of egfr and methods of use thereof
JP2021514400A (ja) * 2018-02-20 2021-06-10 デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド Ｅｇｆｒの阻害剤およびその使用法
JP2021514012A (ja) * 2018-02-20 2021-06-03 デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド Ｅｇｆｒの分解誘導剤およびその使用法
JP7252973B2 (ja) 2018-03-26 2023-04-05 ノバルティス アーゲー Ｎ－（３－（７Ｈ－ピロロ［２，３－ｄ］ピリミジン－４－イル）フェニル）ベンズアミド誘導体
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