CA3018126A1 - Mutant bordetella strains and methods of use - Google Patents
Mutant bordetella strains and methods of use Download PDFInfo
- Publication number
- CA3018126A1 CA3018126A1 CA3018126A CA3018126A CA3018126A1 CA 3018126 A1 CA3018126 A1 CA 3018126A1 CA 3018126 A CA3018126 A CA 3018126A CA 3018126 A CA3018126 A CA 3018126A CA 3018126 A1 CA3018126 A1 CA 3018126A1
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- pertactin
- deficient
- respiratory tract
- live attenuated
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/36—Adaptation or attenuation of cells
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- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
- A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
- A61K2039/543—Mucosal route intranasal
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- A—HUMAN NECESSITIES
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- A61K2039/57—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2
- A61K2039/575—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 humoral response
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- A61K2039/58—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation
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| PCT/EP2017/057468 WO2017167834A1 (en) | 2016-03-29 | 2017-03-29 | Mutant bordetella strains and methods for use |
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| CA3018126A1 true CA3018126A1 (en) | 2017-10-05 |
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| BRPI0707102B1 (pt) * | 2006-03-10 | 2022-05-31 | Institut Pasteur De Lille | Composição imunogênica |
| CA2759280C (en) | 2009-04-28 | 2016-09-20 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Vaccine for prophylaxis or treatment of an allergen-driven airway pathology |
| AU2017242541B2 (en) * | 2016-03-29 | 2022-06-30 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Mutant bordetella strains and methods for use |
| CA3077428A1 (en) | 2017-10-18 | 2019-04-25 | Institut Pasteur De Lille | Bordetella strains expressing serotype 3 fimbriae |
| BR112023002549A2 (pt) | 2020-08-14 | 2023-03-07 | Iliad Biotechnologies Llc | Método de fabricação de uma vacina liofilizada compreendendo bactérias bordetella vivas atenuadas e produto de vacina liofilizada |
| CN116635517A (zh) | 2020-11-17 | 2023-08-22 | 伊利亚德生物技术有限公司 | 与神经退行性疾病相关的神经病理的治疗和预防 |
| JP2025525623A (ja) | 2022-07-22 | 2025-08-05 | アンスティチュ ナシヨナル デュ ラ サンテ エト デュ ラ レシェルシェ メディカレ | 慢性閉塞性肺疾患の治療のためのボルデテラ（ｂｏｒｄｅｔｅｌｌａ）菌株の使用 |
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| US6713072B1 (en) | 1987-11-02 | 2004-03-30 | Chiron S.R.L. | Immunologically active polypeptides with altered toxicity useful for the preparation of an antipertussis vaccine |
| GB9115332D0 (en) * | 1991-07-16 | 1991-08-28 | Connaught Lab | Manipulation of gene copy number in bordetella |
| FR2718750B1 (fr) | 1994-04-19 | 1996-06-14 | Pasteur Institut | Protéines recombinantes de l'hémagglutinine filamenteuse de Bordetella, notamment, B. Pertussis, production et application à la production de protéines étrangères ou de principes actifs vaccinants. |
| CN1147259A (zh) * | 1994-04-28 | 1997-04-09 | 武田药品工业株式会社 | 分离百日咳杆菌保护性组分的方法 |
| FR2754543B1 (fr) * | 1996-10-11 | 1998-12-31 | Pasteur Institut | Souche de bordetella deficiente dans la production de toxine et exprimant une proteine hydride, liposomes comprenant de la fha et leurs utilisations comme vaccins, et utilisation de la fha pour stimuler les reponses immunitaires |
| FR2840319B1 (fr) | 2002-05-30 | 2004-08-20 | Pasteur Institut | Souches de bordetella rendues deficientes par attenuation genetique |
| EP1617805A4 (en) | 2003-04-11 | 2012-07-04 | Medimmune Llc | METHODS FOR PREVENTING OR TREATING RESPIRATORY CONDITIONS |
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| WO2008058396A1 (en) | 2006-11-15 | 2008-05-22 | Folia Biotech Inc. | Papaya mosaic virus-based vaccines for influenza |
| EP2134359A4 (en) | 2007-02-23 | 2010-06-16 | Penn State Res Found | USE OF A NONVIRULENT BORDETELLA MUTANT AS LIVING VACCINE VECTOR |
| US20100104533A1 (en) | 2007-06-18 | 2010-04-29 | Carter William A | Early intervention of viral infection with immune activators |
| CA2759280C (en) * | 2009-04-28 | 2016-09-20 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Vaccine for prophylaxis or treatment of an allergen-driven airway pathology |
| JP5551774B2 (ja) | 2009-06-15 | 2014-07-16 | ナショナル ユニヴァーシティー オブ シンガポール | インフルエンザワクチン、組成物、および使用方法 |
| US9415077B2 (en) * | 2011-11-02 | 2016-08-16 | Institut National De La Sante Et De La Recherche Medicale | Effect of an attenuated Bordetella strain against allergic disease |
| CN102793915B (zh) * | 2012-07-25 | 2013-10-23 | 天津康希诺生物技术有限公司 | 一种无细胞百日咳疫苗的生产方法 |
| EP2722338A1 (en) | 2012-10-17 | 2014-04-23 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Novel recombinant Bordetella strains |
| AU2017242541B2 (en) * | 2016-03-29 | 2022-06-30 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Mutant bordetella strains and methods for use |
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| US10682377B2 (en) | 2020-06-16 |
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| CN109069535A (zh) | 2018-12-21 |
| AU2017242541A1 (en) | 2018-10-11 |
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| US20200323901A1 (en) | 2020-10-15 |
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| US20210290667A1 (en) | 2021-09-23 |
| ES3027194T3 (en) | 2025-06-13 |
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| US20230381224A1 (en) | 2023-11-30 |
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