CA3014458A1 - T-cell modulatory multimeric polypeptides and methods of use thereof - Google Patents
T-cell modulatory multimeric polypeptides and methods of use thereofInfo
- Publication number
- CA3014458A1 CA3014458A1 CA3014458A CA3014458A CA3014458A1 CA 3014458 A1 CA3014458 A1 CA 3014458A1 CA 3014458 A CA3014458 A CA 3014458A CA 3014458 A CA3014458 A CA 3014458A CA 3014458 A1 CA3014458 A1 CA 3014458A1
- Authority
- CA
- Canada
- Prior art keywords
- polypeptide
- amino acid
- acid sequence
- cases
- variant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662302654P | 2016-03-02 | 2016-03-02 | |
| US62/302,654 | 2016-03-02 | ||
| PCT/US2017/020276 WO2017151818A2 (en) | 2016-03-02 | 2017-03-01 | T-cell modulatory multimeric polypeptides and methods of use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3014458A1 true CA3014458A1 (en) | 2017-09-08 |
Family
ID=59743228
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3014458A Abandoned CA3014458A1 (en) | 2016-03-02 | 2017-03-01 | T-cell modulatory multimeric polypeptides and methods of use thereof |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US20190062400A1 (OSRAM) |
| EP (1) | EP3423108A4 (OSRAM) |
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| JP2016500255A (ja) | 2012-12-11 | 2016-01-12 | アルバート アインシュタイン カレッジ オブ メディシン オブ イエシバ ユニバーシティ | ハイスループットなレセプター：リガンド同定の方法 |
| EP3875477A1 (en) | 2015-04-17 | 2021-09-08 | Alpine Immune Sciences, Inc. | Immunomodulatory proteins with tunable affinities |
| BR112018008865A8 (pt) | 2015-11-02 | 2019-02-26 | Five Prime Therapeutics Inc | polipeptídeos do domínio extracelular cd80 e seu uso no tratamento do câncer |
| AU2017248830B2 (en) | 2016-04-15 | 2023-03-09 | Alpine Immune Sciences, Inc. | CD80 variant immunomodulatory proteins and uses thereof |
| CA3022331A1 (en) | 2016-05-18 | 2017-11-23 | Albert Einstein College Of Medicine, Inc. | Variant pd-l1 polypeptides, t-cell modulatory multimeric polypeptides, and methods of use thereof |
| AU2017268348A1 (en) * | 2016-05-18 | 2018-10-25 | Cue Biopharma, Inc. | T-cell modulatory multimeric polypeptides and methods of use thereof |
| IL303806B2 (en) | 2016-12-22 | 2024-05-01 | Cue Biopharma Inc | Multimeric polypeptides modulate T cells and methods for their use |
| WO2018129474A1 (en) | 2017-01-09 | 2018-07-12 | Cue Biopharma, Inc. | T-cell modulatory multimeric polypeptides and methods of use thereof |
| WO2018170168A1 (en) | 2017-03-15 | 2018-09-20 | Cue Biopharma, Inc. | Methods for modulating an immune response |
| IL319966A (en) | 2017-03-16 | 2025-05-01 | Alpine Immune Sciences Inc | CD80 Variant Immune Modulator Proteins and Uses Thereof |
| MX2019012849A (es) | 2017-04-28 | 2019-11-28 | Five Prime Therapeutics Inc | Metodos de tratamiento con polipeptidos del dominio extracelular del cd80. |
| KR20200064085A (ko) * | 2017-09-07 | 2020-06-05 | 큐 바이오파마, 인크. | 접합 부위를 갖는 t-세포 조절 다량체 폴리펩타이드 및 이의 사용 방법 |
| KR20200064083A (ko) * | 2017-09-07 | 2020-06-05 | 큐 바이오파마, 인크. | 항원-제시 폴리펩티드 및 이의 사용 방법 |
| CN111886241A (zh) | 2018-01-09 | 2020-11-03 | 库尔生物制药有限公司 | 多聚体t细胞调节多肽及其使用方法 |
| WO2020132368A1 (en) * | 2018-12-19 | 2020-06-25 | Cue Biopharma, Inc. | T-cell modulatory multimeric polypeptides with conjugation sites and methods of use thereof |
| WO2020181272A1 (en) * | 2019-03-06 | 2020-09-10 | Cue Biopharma, Inc. | Antigen-presenting polypeptides with chemical conjugation sites and methods of use thereof |
| MX2021014476A (es) * | 2019-05-29 | 2022-02-11 | Cue Biopharma Inc | Polipeptidos multimericos moduladores de linfocitos t y metodos de uso de estos. |
| AU2020348373A1 (en) * | 2019-09-20 | 2022-02-24 | Cue Biopharma, Inc. | T-cell modulatory polypeptides and methods of use thereof |
| CA3155510A1 (en) | 2019-10-23 | 2021-04-29 | III Ronald D. SEIDEL | Tgf-.beta. polypeptides |
| WO2021178975A1 (en) * | 2020-03-06 | 2021-09-10 | Albert Einstein College Of Medicine | A method to generate chimeric antigen receptor (car) t-cells (car-t cells) from pathogen-specific cytotoxic lymphocytes to enable the subsequent in vivo modulation of their functional activity |
| WO2021181233A2 (en) * | 2020-03-09 | 2021-09-16 | Pfizer Inc. | Fusion proteins and uses thereof |
| IL296209A (en) | 2020-05-12 | 2022-11-01 | Cue Biopharma Inc | Multimeric t-cell modulatory polypeptides and methods of using them |
| EP4157350A4 (en) * | 2020-05-26 | 2025-07-23 | Cue Biopharma Inc | ANTIGEN-PRESENTING POLYPEPTIDE COMPLEXES AND METHODS OF USE THEREOF |
| US20230201335A1 (en) * | 2020-05-26 | 2023-06-29 | Cue Biopharma, Inc. | Antigen Presenting Polypeptide Complexes and Methods of Use Thereof |
| US20230279076A1 (en) * | 2020-07-14 | 2023-09-07 | Cue Biopharma, Inc. | T-Cell Modulatory Polypeptides with Conjugation Sites and Methods of Use Thereof |
| JP2023541366A (ja) | 2020-09-09 | 2023-10-02 | キュー バイオファーマ， インコーポレイテッド | １型真性糖尿病（ｔ１ｄ）を治療するためのｍｈｃクラスｉｉ ｔ細胞調節多量体ポリペプチド及びその使用方法 |
| CN118076376A (zh) * | 2021-04-21 | 2024-05-24 | 库尔生物制药有限公司 | 携带TGF-β的抗原呈递多肽复合物及其使用方法 |
| US20240270815A1 (en) * | 2021-05-26 | 2024-08-15 | Cue Biopharma, Inc. | Antigen Presenting Polypeptide Complexes and Methods of Use Thereof |
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| KR100692227B1 (ko) * | 1998-04-07 | 2007-03-09 | 코릭사 코포레이션 | 마이코박테리움 튜베르쿨로시스 항원의 융합 단백질 및이의 용도 |
| PT2726101T (pt) * | 2011-06-30 | 2018-11-21 | Genzyme Corp | Inibidores da ativação de células t |
| CN102898504B (zh) * | 2012-10-23 | 2014-08-06 | 中国农业大学 | 抗氧化活性合成肽及其用途 |
| EP3480213B1 (en) * | 2014-06-18 | 2019-11-13 | Albert Einstein College of Medicine | Syntac polypeptides and uses thereof |
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2017
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2018
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2022
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| US20230227530A1 (en) | 2023-07-20 |
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| AU2017226269B2 (en) | 2021-10-28 |
| JP2019516665A (ja) | 2019-06-20 |
| WO2017151818A2 (en) | 2017-09-08 |
| US20190062400A1 (en) | 2019-02-28 |
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| EP3423108A4 (en) | 2019-10-02 |
| EP3423108A2 (en) | 2019-01-09 |
| WO2017151818A3 (en) | 2017-10-26 |
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