CA3013532C - Liraglutide in cardiovascular conditions - Google Patents

Liraglutide in cardiovascular conditions Download PDF

Info

Publication number
CA3013532C
CA3013532C CA3013532A CA3013532A CA3013532C CA 3013532 C CA3013532 C CA 3013532C CA 3013532 A CA3013532 A CA 3013532A CA 3013532 A CA3013532 A CA 3013532A CA 3013532 C CA3013532 C CA 3013532C
Authority
CA
Canada
Prior art keywords
subject
placebo
liraglutide
mace
death
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA3013532A
Other languages
English (en)
French (fr)
Other versions
CA3013532A1 (en
Inventor
Soren Rasmussen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novo Nordisk AS
Original Assignee
Novo Nordisk AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=59723004&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA3013532(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novo Nordisk AS filed Critical Novo Nordisk AS
Publication of CA3013532A1 publication Critical patent/CA3013532A1/en
Application granted granted Critical
Publication of CA3013532C publication Critical patent/CA3013532C/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/26Glucagons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02Inorganic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/08Solutions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Hematology (AREA)
  • Inorganic Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Vascular Medicine (AREA)
  • Dermatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Plant Substances (AREA)
CA3013532A 2016-03-04 2017-03-03 Liraglutide in cardiovascular conditions Expired - Fee Related CA3013532C (en)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
EP16158739.9 2016-03-04
EP16158739 2016-03-04
EP16173917.2 2016-06-10
EP16173917 2016-06-10
EP16001329 2016-06-13
EP16001329.8 2016-06-13
US15/401,651 US9968659B2 (en) 2016-03-04 2017-01-09 Liraglutide in cardiovascular conditions
US15/401651 2017-01-09
PCT/EP2017/054990 WO2017149112A1 (en) 2016-03-04 2017-03-03 Liraglutide in cardiovascular conditions

Publications (2)

Publication Number Publication Date
CA3013532A1 CA3013532A1 (en) 2017-09-08
CA3013532C true CA3013532C (en) 2019-07-23

Family

ID=59723004

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3013532A Expired - Fee Related CA3013532C (en) 2016-03-04 2017-03-03 Liraglutide in cardiovascular conditions

Country Status (24)

Country Link
US (2) US9968659B2 (cg-RX-API-DMAC7.html)
EP (1) EP3423082B1 (cg-RX-API-DMAC7.html)
JP (1) JP6940512B2 (cg-RX-API-DMAC7.html)
KR (1) KR102417455B1 (cg-RX-API-DMAC7.html)
CN (2) CN116327897A (cg-RX-API-DMAC7.html)
AU (2) AU2017225841A1 (cg-RX-API-DMAC7.html)
BR (1) BR112018067344A2 (cg-RX-API-DMAC7.html)
CA (1) CA3013532C (cg-RX-API-DMAC7.html)
CL (1) CL2018002515A1 (cg-RX-API-DMAC7.html)
DK (1) DK3423082T5 (cg-RX-API-DMAC7.html)
ES (1) ES2893755T3 (cg-RX-API-DMAC7.html)
HR (1) HRP20211492T1 (cg-RX-API-DMAC7.html)
HU (1) HUE055844T2 (cg-RX-API-DMAC7.html)
IL (1) IL261169B (cg-RX-API-DMAC7.html)
MA (1) MA43704A (cg-RX-API-DMAC7.html)
MX (1) MX394179B (cg-RX-API-DMAC7.html)
MY (1) MY195657A (cg-RX-API-DMAC7.html)
PH (1) PH12018501844B1 (cg-RX-API-DMAC7.html)
PL (1) PL3423082T3 (cg-RX-API-DMAC7.html)
RS (1) RS62501B1 (cg-RX-API-DMAC7.html)
RU (1) RU2745604C2 (cg-RX-API-DMAC7.html)
SI (1) SI3423082T1 (cg-RX-API-DMAC7.html)
WO (1) WO2017149112A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA201805538B (cg-RX-API-DMAC7.html)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9968659B2 (en) 2016-03-04 2018-05-15 Novo Nordisk A/S Liraglutide in cardiovascular conditions
CA3056663C (en) 2019-04-05 2022-10-18 Jeffrey S. RIESMEYER Use of dulaglutide in reducing risk of cardiovascular events in patients with type 2 diabetes mellitus
CN117320755A (zh) * 2020-12-16 2023-12-29 香港中文大学 一种逆转衰老性脑功能衰退的方法

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5808203A (en) 1997-05-12 1998-09-15 Medrad, Inc. Fluid pressure measurement devices
WO2003084563A1 (en) * 2002-04-04 2003-10-16 Novo Nordisk A/S Glp-1 agonist and cardiovascular complications
CN1882356B (zh) * 2003-11-20 2015-02-25 诺沃挪第克公司 对于生产和用于注射装置中是最佳的含有丙二醇的肽制剂
CN101056650A (zh) * 2004-11-12 2007-10-17 诺和诺德公司 促胰岛素肽的稳定制剂
WO2009030738A1 (en) * 2007-09-05 2009-03-12 Novo Nordisk A/S Glucagon-like peptide-1 derivatives and their pharmaceutical use
UY32030A (es) 2008-08-06 2010-03-26 Boehringer Ingelheim Int "tratamiento para diabetes en pacientes inapropiados para terapia con metformina"
AR074990A1 (es) 2009-01-07 2011-03-02 Boehringer Ingelheim Int Tratamiento de diabetes en pacientes con un control glucemico inadecuado a pesar de la terapia con metformina
TWI466672B (zh) 2009-01-29 2015-01-01 Boehringer Ingelheim Int 小兒科病人糖尿病之治療
JP2012522015A (ja) 2009-03-27 2012-09-20 ブリストル−マイヤーズ スクイブ カンパニー Dpp−iv阻害剤を用いて主要有害心血管事象を予防する方法
US8691763B2 (en) 2010-05-04 2014-04-08 Glaxosmithkline Llc Methods for treating or preventing cardiovascular disorders and providing cardiovascular protection
MX2012014247A (es) 2010-06-24 2013-01-18 Boehringer Ingelheim Int Terapia para la diabetes.
AR083878A1 (es) 2010-11-15 2013-03-27 Boehringer Ingelheim Int Terapia antidiabetica vasoprotectora y cardioprotectora, linagliptina, metodo de tratamiento
US20130172244A1 (en) 2011-12-29 2013-07-04 Thomas Klein Subcutaneous therapeutic use of dpp-4 inhibitor
US20130303554A1 (en) 2012-05-14 2013-11-14 Boehringer Ingelheim International Gmbh Use of a dpp-4 inhibitor in sirs and/or sepsis
US20130303462A1 (en) 2012-05-14 2013-11-14 Boehringer Ingelheim International Gmbh Use of a dpp-4 inhibitor in podocytes related disorders and/or nephrotic syndrome
EP2854812A1 (en) 2012-05-24 2015-04-08 Boehringer Ingelheim International GmbH A xanthine derivative as dpp -4 inhibitor for use in the treatment of autoimmune diabetes, particularly lada
CN103893744B (zh) * 2012-12-24 2017-12-19 杭州九源基因工程有限公司 一种治疗糖尿病的药物制剂及其制备方法
EP4364796A3 (en) 2013-03-15 2024-07-24 Boehringer Ingelheim International GmbH Use of linagliptin in cardio- and renoprotective antidiabetic therapy
JP6507154B2 (ja) 2013-06-14 2019-04-24 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 糖尿病及びその合併症を治療するためのddp−4阻害薬
US8969371B1 (en) 2013-12-06 2015-03-03 Orexigen Therapeutics, Inc. Compositions and methods for weight loss in at risk patient populations
WO2015128453A1 (en) 2014-02-28 2015-09-03 Boehringer Ingelheim International Gmbh Medical use of a dpp-4 inhibitor
WO2016019587A1 (en) 2014-08-08 2016-02-11 Merck Sharp & Dohme Corp. [7, 6]-fused bicyclic antidiabetic compounds
US9968659B2 (en) 2016-03-04 2018-05-15 Novo Nordisk A/S Liraglutide in cardiovascular conditions

Also Published As

Publication number Publication date
MX394179B (es) 2025-03-24
IL261169B (en) 2019-11-28
PH12018501844B1 (en) 2023-03-17
MA43704A (fr) 2021-04-14
CL2018002515A1 (es) 2018-11-09
DK3423082T5 (da) 2023-02-06
SI3423082T1 (sl) 2021-10-29
WO2017149112A1 (en) 2017-09-08
ZA201805538B (en) 2020-05-27
HUE055844T2 (hu) 2021-12-28
RS62501B1 (sr) 2021-11-30
JP6940512B2 (ja) 2021-09-29
KR102417455B1 (ko) 2022-07-06
CN116327897A (zh) 2023-06-27
AU2017225841A1 (en) 2018-08-23
RU2018134061A (ru) 2020-04-06
PL3423082T3 (pl) 2021-12-27
MX2018010097A (es) 2018-11-09
US20170252408A1 (en) 2017-09-07
US9968659B2 (en) 2018-05-15
DK3423082T3 (da) 2021-10-11
US20180236038A1 (en) 2018-08-23
PH12018501844A1 (en) 2019-05-15
KR20180114168A (ko) 2018-10-17
JP2019507174A (ja) 2019-03-14
CN108778317A (zh) 2018-11-09
BR112018067344A2 (pt) 2019-01-08
CA3013532A1 (en) 2017-09-08
HRP20211492T1 (hr) 2021-12-24
IL261169A (en) 2018-10-31
MY195657A (en) 2023-02-03
RU2745604C2 (ru) 2021-03-29
RU2018134061A3 (cg-RX-API-DMAC7.html) 2020-07-15
ES2893755T3 (es) 2022-02-10
AU2024201937A1 (en) 2024-04-11
EP3423082A1 (en) 2019-01-09
EP3423082B1 (en) 2021-08-04

Similar Documents

Publication Publication Date Title
US20250262281A1 (en) Semaglutide in Cardiovascular Conditions
US12233114B2 (en) Method for treating diabetes
AU2024201937A1 (en) Liraglutide in cardiovascular conditions
US11673933B2 (en) Method for using insulin degludec for the improvement of glycemic control and reduction of acute and long-term diabetes complications
US20190091295A1 (en) Liraglutide in Renal Conditions
US20190070266A1 (en) Liraglutide in Diabetic Foot Ulcer
HK1259166B (en) Liraglutide in cardiovascular conditions
HK1259166A1 (en) Liraglutide in cardiovascular conditions
WO2018096164A1 (en) Insulin degludec for treating diabetes

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20180802

EEER Examination request

Effective date: 20180802

MKLA Lapsed

Effective date: 20210903

MKLA Lapsed

Effective date: 20200303

MKLA Lapsed

Effective date: 20200303