CA3011661C - Dielectric sensing for sample characterization - Google Patents

Dielectric sensing for sample characterization Download PDF

Info

Publication number
CA3011661C
CA3011661C CA3011661A CA3011661A CA3011661C CA 3011661 C CA3011661 C CA 3011661C CA 3011661 A CA3011661 A CA 3011661A CA 3011661 A CA3011661 A CA 3011661A CA 3011661 C CA3011661 C CA 3011661C
Authority
CA
Canada
Prior art keywords
permittivity
dielectric
sut
signal
input
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA3011661A
Other languages
English (en)
French (fr)
Other versions
CA3011661A1 (en
Inventor
Michael Suster
Pedram MOHSENI
Debnath MAJI
Evi STAVROU
Umut Gurkan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Case Western Reserve University
Original Assignee
Case Western Reserve University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Case Western Reserve University filed Critical Case Western Reserve University
Publication of CA3011661A1 publication Critical patent/CA3011661A1/en
Application granted granted Critical
Publication of CA3011661C publication Critical patent/CA3011661C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/05Detecting, measuring or recording for diagnosis by means of electric currents or magnetic fields; Measuring using microwaves or radio waves
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61BDIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00Measuring for diagnostic purposes; Identification of persons
    • A61B5/145Measuring characteristics of blood in vivo, e.g. gas concentration or pH-value ; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid or cerebral tissue
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/02Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance
    • G01N27/026Dielectric impedance spectroscopy
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/02Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance
    • G01N27/04Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance
    • G01N27/06Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance of a liquid
    • G01N27/08Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating resistance of a liquid which is flowing continuously
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/02Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance
    • G01N27/22Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating capacitance
    • G01N27/221Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating impedance by investigating capacitance by investigating the dielectric properties
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483Physical analysis of biological material
    • G01N33/487Physical analysis of biological material of liquid biological material
    • G01N33/49Blood
    • G01N33/4905Determining clotting time of blood

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Electrochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Medical Informatics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Ecology (AREA)
  • Optics & Photonics (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
CA3011661A 2016-01-15 2017-01-17 Dielectric sensing for sample characterization Active CA3011661C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662279467P 2016-01-15 2016-01-15
US62/279,467 2016-01-15
PCT/US2017/013797 WO2017124104A1 (en) 2016-01-15 2017-01-17 Dielectric sensing for sample characterization

Publications (2)

Publication Number Publication Date
CA3011661A1 CA3011661A1 (en) 2017-07-20
CA3011661C true CA3011661C (en) 2024-04-02

Family

ID=59311590

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3011661A Active CA3011661C (en) 2016-01-15 2017-01-17 Dielectric sensing for sample characterization

Country Status (9)

Country Link
US (2) US10674931B2 (enExample)
EP (1) EP3403080B1 (enExample)
JP (1) JP6936235B2 (enExample)
KR (1) KR102810749B1 (enExample)
CN (1) CN108780056B (enExample)
AU (1) AU2017207027B2 (enExample)
BR (1) BR112018014522B1 (enExample)
CA (1) CA3011661C (enExample)
WO (1) WO2017124104A1 (enExample)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112018014522B1 (pt) * 2016-01-15 2023-05-09 Case Western Reserve University Detecção dielétrica para caracterização de amostra
WO2018106194A1 (en) * 2016-12-09 2018-06-14 Nanyang Technological University Non-destructive testing methods and apparatus
US11016075B2 (en) * 2017-07-20 2021-05-25 Saudi Arabian Oil Company Methods and systems for characterization of geochemical properties of hydrocarbons using microwaves
US11850586B2 (en) 2017-07-27 2023-12-26 Maxim Integrated Products, Inc. Analyte sensor package and method for analyzing fluid samples
JP7173731B2 (ja) * 2017-12-15 2022-11-16 株式会社 堀場アドバンスドテクノ 電磁気センサ
JP7230429B2 (ja) * 2018-10-25 2023-03-01 ソニーグループ株式会社 血小板凝集能解析装置、血小板凝集能解析方法及び血小板凝集能解析システム
WO2020106536A1 (en) * 2018-11-20 2020-05-28 Xa Tek, Inc. Portable dielectric spectroscopy device
WO2020106556A1 (en) 2018-11-20 2020-05-28 Xatek, Inc. Dielectric spectroscopy sensing apparaus and method of use
US11408844B2 (en) * 2019-04-02 2022-08-09 Case Western Reserve University Dielectric sensing to characterize hemostatic dysfunction
US11774388B2 (en) * 2019-04-02 2023-10-03 Case Western Reserve University Dielectric sensing to characterize hemostatic dysfunction
CN112294296A (zh) * 2019-08-02 2021-02-02 永健生技医疗器材有限公司 非侵入性血糖测试机系统及方法
WO2021041820A1 (en) 2019-08-29 2021-03-04 Ppg Industries Ohio, Inc. Radio frequency signaling system and curable composition
CN111289583A (zh) * 2020-02-19 2020-06-16 华北电力大学 一种凝胶类材料宽频介电特性的测试装置及方法
EP3940377A1 (en) 2020-07-16 2022-01-19 3M Innovative Properties Company Method, data set and sensor to sense a property of a liquid
DE102021204570A1 (de) 2021-05-06 2022-11-10 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung eingetragener Verein Dosierkopf und Fluidiksystem zur Aufnahme und Dosierung wenigstens eines Mediums
WO2023132027A1 (ja) * 2022-01-06 2023-07-13 日本電信電話株式会社 誘電分光センサ
GB2621856B (en) * 2022-08-24 2025-01-08 Africa New Energies Ltd Fluid monitoring
WO2024130650A1 (zh) * 2022-12-22 2024-06-27 深圳华大智造科技股份有限公司 感测系统、芯片封装结构、测序载片及测序方法
US12498341B2 (en) * 2023-09-29 2025-12-16 L'oreal Electronicless accessory recognition using dielectric properties

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4686857A (en) 1983-03-04 1987-08-18 Kabushiki Kaisha Toyota Chuo Kenkyusho Method and apparatus for evaluating the performance of dielectric substances
US4765179A (en) * 1985-09-09 1988-08-23 Solid State Farms, Inc. Radio frequency spectroscopy apparatus and method using multiple frequency waveforms
US4884457A (en) 1987-09-30 1989-12-05 Texaco Inc. Means and method for monitoring the flow of a multi-phase petroleum stream
US5389218A (en) * 1989-01-24 1995-02-14 Gas Research Institute Process for operating a solid-state oxygen microsensor
US5042299A (en) 1990-07-23 1991-08-27 Iimorrow, Inc. Capacitive fluid level sensor
AU736392B2 (en) 1997-10-22 2001-07-26 Japan National Oil Corporation Method of measuring flow rates of respective fluids constituting multiphase fluid and flow meter for multiphase flow utilizing the same
US6255954B1 (en) 1999-01-29 2001-07-03 Reid Asset Management Company Detection of wear-particles and other impurities in industrial or other fluids
US6362632B1 (en) 2000-05-24 2002-03-26 Becs Technology, Inc. Balanced charge pump capacitive material sensor
GB0030929D0 (en) * 2000-12-19 2001-01-31 Inverness Medical Ltd Analyte measurement
CA2462341C (en) 2001-10-12 2010-12-14 Wisconsin Alumni Research Foundation Microwave dielectric spectroscopy method and apparatus for assays of proteins and other biological molecules
US7291310B2 (en) * 2002-12-17 2007-11-06 The Regents Of The University Of Michigan Microsystem for determining clotting time of blood and low-cost, single-use device for use therein
US6945116B2 (en) * 2003-03-19 2005-09-20 California Institute Of Technology Integrated capacitive microfluidic sensors method and apparatus
US6922064B2 (en) 2003-06-18 2005-07-26 General Motors Corporation Fluid quality test method based on impedance
JP4775262B2 (ja) * 2004-09-03 2011-09-21 三菱化学株式会社 センサユニット及び反応場セルユニット並びに分析装置
US7541004B2 (en) 2004-11-12 2009-06-02 Predict, Inc. MEMS-based sensor for lubricant analysis
USD558086S1 (en) 2005-10-14 2007-12-25 Diana Kathryne Herber Heirloom balloon
EP2156172B1 (en) * 2007-06-20 2013-02-20 MEC Dynamics Corporation Apparatus for measuring blood coagulation
TWI516601B (zh) 2007-10-26 2016-01-11 環球生物醫療感測器私人有限公司 電化學檢測之裝置及方法
US8578761B2 (en) 2008-03-26 2013-11-12 Denso Corporation Concentration sensor device and concentration detecting method
JP5691168B2 (ja) 2009-01-08 2015-04-01 ソニー株式会社 血液凝固系解析装置、血液凝固系解析方法及びプログラム
WO2010109317A1 (en) 2009-03-26 2010-09-30 Pricol Limited Capacitive measurement of fuel level and dielectric constant
US8281655B2 (en) 2009-04-03 2012-10-09 Eaton Corporation Fuel gauging system utilizing a digital fuel gauging probe
US8926904B2 (en) * 2009-05-12 2015-01-06 Daniel Wai-Cheong So Method and apparatus for the analysis and identification of molecules
US20120055810A1 (en) 2009-05-29 2012-03-08 University Of Miami Solid-state electrochemical sensor
US20110234240A1 (en) 2010-03-23 2011-09-29 Empire Technology Development, Llc Monitoring dehydration using rf dielectric resonator oscillator
KR101663010B1 (ko) 2010-11-09 2016-10-06 삼성전자주식회사 Rf용 매칭 세그먼트 회로 및 이를 이용한 rf통합 소자
WO2012076683A1 (fr) * 2010-12-09 2012-06-14 Arthur Queval Dispositif micro-fluidique pour l'analyse d'un échantillon de fluide
US8776246B2 (en) 2011-03-11 2014-07-08 Abbott Point Of Care, Inc. Systems, methods and analyzers for establishing a secure wireless network in point of care testing
JP5768422B2 (ja) * 2011-03-17 2015-08-26 ソニー株式会社 血液凝固系解析方法および血液凝固系解析装置
US9597149B2 (en) 2011-11-04 2017-03-21 Iogyn, Inc. Tissue extraction devices and methods
WO2013096801A1 (en) 2011-12-23 2013-06-27 Abbott Point Of Care Inc Reader devices for optical and electrochemical test devices
US9539389B2 (en) 2012-02-08 2017-01-10 Stmicroelectronics, Inc. Wireless flow sensor using present flow rate data
US8884771B2 (en) 2012-08-01 2014-11-11 Microchip Technology Incorporated Smoke detection using change in permittivity of capacitor air dielectric
CN103712600B (zh) * 2012-10-08 2016-05-25 硕英股份有限公司 液体电容式倾斜微传感器
US20140114592A1 (en) 2012-10-22 2014-04-24 Custom Electronics, Inc. Operational monitoring of electrochemical capacitors
EP2947451A4 (en) 2013-01-18 2016-08-17 Sony Corp DEVICE FOR MEASURING ELECTRICAL PROPERTIES
EP2975387B1 (en) 2013-03-13 2021-03-31 Sony Corporation Device for analyzing condition of blood, system for analyzing condition of blood, and program for analyzing condition of blood
US9995701B2 (en) * 2014-06-02 2018-06-12 Case Western Reserve University Capacitive sensing apparatuses, systems and methods of making same
PE20170737A1 (es) 2014-09-09 2017-07-04 Perosphere Inc Analisis de coagulacion universal microfluido basado en chips
CN104668003B (zh) * 2015-01-20 2016-06-29 天津农学院 微流控芯片
CN105117085B (zh) * 2015-09-07 2018-03-27 武汉华星光电技术有限公司 内嵌式触控面板及其制造方法
BR112018014522B1 (pt) * 2016-01-15 2023-05-09 Case Western Reserve University Detecção dielétrica para caracterização de amostra

Also Published As

Publication number Publication date
US10674931B2 (en) 2020-06-09
BR112018014522A8 (pt) 2023-05-02
KR102810749B1 (ko) 2025-05-21
AU2017207027B2 (en) 2021-11-18
EP3403080A4 (en) 2019-09-04
US20200405173A1 (en) 2020-12-31
US11058316B2 (en) 2021-07-13
AU2017207027A1 (en) 2018-08-16
BR112018014522A2 (pt) 2019-01-15
BR112018014522B1 (pt) 2023-05-09
CN108780056A (zh) 2018-11-09
EP3403080A1 (en) 2018-11-21
WO2017124104A1 (en) 2017-07-20
KR20180103944A (ko) 2018-09-19
CA3011661A1 (en) 2017-07-20
EP3403080B1 (en) 2025-07-23
JP2019505792A (ja) 2019-02-28
CN108780056B (zh) 2022-03-25
JP6936235B2 (ja) 2021-09-15
US20190029555A1 (en) 2019-01-31

Similar Documents

Publication Publication Date Title
US11058316B2 (en) Dielectric sensing for sample characterization
Feng et al. A microfluidic device integrating impedance flow cytometry and electric impedance spectroscopy for high-efficiency single-cell electrical property measurement
Mondal et al. Microwave assisted non-invasive microfluidic biosensor for monitoring glucose concentration
JP6243446B2 (ja) 共振センサを使用して流体を分析するための方法
EP2939184B1 (en) Resonant sensor assembly for analysis of fluids
US8409875B2 (en) Measurement of binding kinetics with a resonating sensor
Maji et al. ClotChip: A microfluidic dielectric sensor for point-of-care assessment of hemostasis
US9220448B2 (en) Ultra-wide band non-invasive biological sensor and method
US11175252B2 (en) Dielectric sensing for blood characterization
JP2019505792A5 (enExample)
TW201202705A (en) Device and method for measuring prothrombin time and hematocrit by analyzing change in reactance in a sample
KR101771829B1 (ko) 분석물질을 전기화학적으로 측정하는 디스크립터-기반 방법들 및 그것을 통합한 디바이스들, 장치들 및 시스템들
Qiang et al. Rapid electrical impedance detection of sickle cell vaso-occlusion in microfluidic device
US12072310B2 (en) Dielectric sensing to characterize properties of a sample under test
US11408844B2 (en) Dielectric sensing to characterize hemostatic dysfunction
Ebrahimi et al. Highly sensitive microwave-based biosensor for electrolytic level measurement in water
Maji et al. A PMMA microfluidic dielectric sensor for blood coagulation monitoring at the point-of-care
SE521208C2 (sv) System och förfarande för blodanalys
Colella On chip cellular dielectric spectroscopy: monitoring of glucose effect on erythrocytes membrane and analysis of the physiological role of anthrax toxin receptor in endothelial cells
CN106770376A (zh) 基于射频技术的生物传感器

Legal Events

Date Code Title Description
EEER Examination request

Effective date: 20211223

EEER Examination request

Effective date: 20211223

EEER Examination request

Effective date: 20211223

EEER Examination request

Effective date: 20211223

EEER Examination request

Effective date: 20211223

EEER Examination request

Effective date: 20211223

EEER Examination request

Effective date: 20211223

EEER Examination request

Effective date: 20211223