CA3009525A1 - Inhibitors of glucocorticoid receptor - Google Patents
Inhibitors of glucocorticoid receptor Download PDFInfo
- Publication number
- CA3009525A1 CA3009525A1 CA3009525A CA3009525A CA3009525A1 CA 3009525 A1 CA3009525 A1 CA 3009525A1 CA 3009525 A CA3009525 A CA 3009525A CA 3009525 A CA3009525 A CA 3009525A CA 3009525 A1 CA3009525 A1 CA 3009525A1
- Authority
- CA
- Canada
- Prior art keywords
- optionally substituted
- alkyl
- compound
- pharmaceutically acceptable
- prodrug
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 239000003112 inhibitor Substances 0.000 title claims description 80
- 102000003676 Glucocorticoid Receptors Human genes 0.000 title abstract description 107
- 108090000079 Glucocorticoid Receptors Proteins 0.000 title abstract description 107
- 150000001875 compounds Chemical class 0.000 claims abstract description 151
- 238000000034 method Methods 0.000 claims abstract description 55
- 206010028980 Neoplasm Diseases 0.000 claims abstract description 53
- 201000011510 cancer Diseases 0.000 claims abstract description 42
- 230000003637 steroidlike Effects 0.000 claims abstract description 20
- 208000014311 Cushing syndrome Diseases 0.000 claims abstract description 18
- 208000037171 Hypercorticoidism Diseases 0.000 claims abstract description 15
- 201000005255 adrenal gland hyperfunction Diseases 0.000 claims abstract description 15
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract description 8
- -1 -OR6 Chemical group 0.000 claims description 252
- 125000005843 halogen group Chemical group 0.000 claims description 185
- 125000000217 alkyl group Chemical group 0.000 claims description 160
- 125000004452 carbocyclyl group Chemical group 0.000 claims description 115
- 125000000623 heterocyclic group Chemical group 0.000 claims description 115
- 229910052739 hydrogen Inorganic materials 0.000 claims description 78
- 150000003839 salts Chemical class 0.000 claims description 73
- 125000004404 heteroalkyl group Chemical group 0.000 claims description 71
- 125000001188 haloalkyl group Chemical group 0.000 claims description 67
- 125000001072 heteroaryl group Chemical group 0.000 claims description 67
- 108010080146 androgen receptors Proteins 0.000 claims description 63
- 239000003814 drug Substances 0.000 claims description 60
- 229940124597 therapeutic agent Drugs 0.000 claims description 59
- 125000000547 substituted alkyl group Chemical group 0.000 claims description 52
- 125000003709 fluoroalkyl group Chemical group 0.000 claims description 51
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- 125000004415 heterocyclylalkyl group Chemical group 0.000 claims description 48
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- 125000005884 carbocyclylalkyl group Chemical group 0.000 claims description 42
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 42
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- 229940002612 prodrug Drugs 0.000 claims description 41
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- 206010060862 Prostate cancer Diseases 0.000 claims description 40
- 125000003107 substituted aryl group Chemical group 0.000 claims description 40
- 239000012453 solvate Substances 0.000 claims description 37
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 36
- 125000003118 aryl group Chemical group 0.000 claims description 34
- 125000003710 aryl alkyl group Chemical group 0.000 claims description 29
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- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 27
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 25
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- 125000004429 atom Chemical group 0.000 claims description 23
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- 125000005842 heteroatom Chemical group 0.000 claims description 19
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- 125000000753 cycloalkyl group Chemical group 0.000 claims description 8
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 7
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- WXCXUHSOUPDCQV-UHFFFAOYSA-N enzalutamide Chemical compound C1=C(F)C(C(=O)NC)=CC=C1N1C(C)(C)C(=O)N(C=2C=C(C(C#N)=CC=2)C(F)(F)F)C1=S WXCXUHSOUPDCQV-UHFFFAOYSA-N 0.000 claims description 7
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 7
- IPRJXAGUEGOFGG-UHFFFAOYSA-N N-butylbenzenesulfonamide Chemical compound CCCCNS(=O)(=O)C1=CC=CC=C1 IPRJXAGUEGOFGG-UHFFFAOYSA-N 0.000 claims description 6
- HJBWBFZLDZWPHF-UHFFFAOYSA-N apalutamide Chemical compound C1=C(F)C(C(=O)NC)=CC=C1N1C2(CCC2)C(=O)N(C=2C=C(C(C#N)=NC=2)C(F)(F)F)C1=S HJBWBFZLDZWPHF-UHFFFAOYSA-N 0.000 claims description 6
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 6
- RQZAXGRLVPAYTJ-GQFGMJRRSA-N megestrol acetate Chemical compound C1=C(C)C2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(C)=O)(OC(=O)C)[C@@]1(C)CC2 RQZAXGRLVPAYTJ-GQFGMJRRSA-N 0.000 claims description 6
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 6
- XMAYWYJOQHXEEK-OZXSUGGESA-N (2R,4S)-ketoconazole Chemical compound C1CN(C(=O)C)CCN1C(C=C1)=CC=C1OC[C@@H]1O[C@@](CN2C=NC=C2)(C=2C(=CC(Cl)=CC=2)Cl)OC1 XMAYWYJOQHXEEK-OZXSUGGESA-N 0.000 claims description 5
- LKJPYSCBVHEWIU-KRWDZBQOSA-N (R)-bicalutamide Chemical compound C([C@@](O)(C)C(=O)NC=1C=C(C(C#N)=CC=1)C(F)(F)F)S(=O)(=O)C1=CC=C(F)C=C1 LKJPYSCBVHEWIU-KRWDZBQOSA-N 0.000 claims description 5
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- MKXKFYHWDHIYRV-UHFFFAOYSA-N flutamide Chemical compound CC(C)C(=O)NC1=CC=C([N+]([O-])=O)C(C(F)(F)F)=C1 MKXKFYHWDHIYRV-UHFFFAOYSA-N 0.000 claims description 5
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- XWXYUMMDTVBTOU-UHFFFAOYSA-N nilutamide Chemical compound O=C1C(C)(C)NC(=O)N1C1=CC=C([N+]([O-])=O)C(C(F)(F)F)=C1 XWXYUMMDTVBTOU-UHFFFAOYSA-N 0.000 claims description 5
- 229960002653 nilutamide Drugs 0.000 claims description 5
- UVIQSJCZCSLXRZ-UBUQANBQSA-N abiraterone acetate Chemical compound C([C@@H]1[C@]2(C)CC[C@@H]3[C@@]4(C)CC[C@@H](CC4=CC[C@H]31)OC(=O)C)C=C2C1=CC=CN=C1 UVIQSJCZCSLXRZ-UBUQANBQSA-N 0.000 claims description 4
- 229960004103 abiraterone acetate Drugs 0.000 claims description 4
- 229960004199 dutasteride Drugs 0.000 claims description 4
- JWJOTENAMICLJG-QWBYCMEYSA-N dutasteride Chemical compound O=C([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)N[C@@H]4CC3)C)CC[C@@]21C)NC1=CC(C(F)(F)F)=CC=C1C(F)(F)F JWJOTENAMICLJG-QWBYCMEYSA-N 0.000 claims description 4
- DBEPLOCGEIEOCV-WSBQPABSSA-N finasteride Chemical compound N([C@@H]1CC2)C(=O)C=C[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H](C(=O)NC(C)(C)C)[C@@]2(C)CC1 DBEPLOCGEIEOCV-WSBQPABSSA-N 0.000 claims description 4
- 229960004039 finasteride Drugs 0.000 claims description 4
- 229960001786 megestrol Drugs 0.000 claims description 4
- WQBIOEFDDDEARX-CHWSQXEVSA-N (4ar,10br)-8-chloro-4-methyl-1,2,4a,5,6,10b-hexahydrobenzo[f]quinolin-3-one Chemical compound C1CC2=CC(Cl)=CC=C2[C@@H]2[C@@H]1N(C)C(=O)CC2 WQBIOEFDDDEARX-CHWSQXEVSA-N 0.000 claims description 3
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims description 3
- VFTRKSBEFQDZKX-UHFFFAOYSA-N 3,3'-diindolylmethane Chemical group C1=CC=C2C(CC=3C4=CC=CC=C4NC=3)=CNC2=C1 VFTRKSBEFQDZKX-UHFFFAOYSA-N 0.000 claims description 3
- VAPSMQAHNAZRKC-PQWRYPMOSA-N Epristeride Chemical compound C1C=C2C=C(C(O)=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H](C(=O)NC(C)(C)C)[C@@]1(C)CC2 VAPSMQAHNAZRKC-PQWRYPMOSA-N 0.000 claims description 3
- VMGWGDPZHXPFTC-HYBUGGRVSA-N Izonsteride Chemical compound CN([C@@H]1CCC2=C3)C(=O)CC[C@]1(C)C2=CC=C3SC(S1)=NC2=C1C=CC=C2CC VMGWGDPZHXPFTC-HYBUGGRVSA-N 0.000 claims description 3
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- 201000009395 primary hyperaldosteronism Diseases 0.000 claims description 3
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- WMPQMBUXZHMEFZ-YJPJVVPASA-N turosteride Chemical compound CN([C@@H]1CC2)C(=O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H](C(=O)N(C(C)C)C(=O)NC(C)C)[C@@]2(C)CC1 WMPQMBUXZHMEFZ-YJPJVVPASA-N 0.000 claims description 3
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- 150000002431 hydrogen Chemical group 0.000 description 23
- HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 23
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Classifications
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- C07J—STEROIDS
- C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
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- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
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- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
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- A61P5/46—Drugs for disorders of the endocrine system of the suprarenal hormones for decreasing, blocking or antagonising the activity of glucocorticosteroids
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0051—Estrane derivatives
- C07J1/0081—Substituted in position 17 alfa and 17 beta
- C07J1/0088—Substituted in position 17 alfa and 17 beta the substituent in position 17 alfa being an unsaturated hydrocarbon group
- C07J1/0096—Alkynyl derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0077—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom
- C07J41/0083—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 substituted in position 11-beta by a carbon atom, further substituted by a group comprising at least one further carbon atom substituted in position 11-beta by an optionally substituted phenyl group not further condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/05—Isotopically modified compounds, e.g. labelled
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane
- C07J1/0003—Androstane derivatives
- C07J1/0011—Androstane derivatives substituted in position 17 by a keto group
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J21/005—Ketals
- C07J21/006—Ketals at position 3
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J21/00—Normal steroids containing carbon, hydrogen, halogen or oxygen having an oxygen-containing hetero ring spiro-condensed with the cyclopenta(a)hydrophenanthrene skeleton
- C07J21/005—Ketals
- C07J21/008—Ketals at position 17
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
- C07J71/0005—Oxygen-containing hetero ring
- C07J71/001—Oxiranes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562387293P | 2015-12-23 | 2015-12-23 | |
| US62/387,293 | 2015-12-23 | ||
| PCT/US2016/068448 WO2017112909A1 (en) | 2015-12-23 | 2016-12-22 | Inhibitors of glucocorticoid receptor |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA3009525A1 true CA3009525A1 (en) | 2017-06-29 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA3009525A Pending CA3009525A1 (en) | 2015-12-23 | 2016-12-22 | Inhibitors of glucocorticoid receptor |
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|---|---|
| US (1) | US11208432B2 (enExample) |
| EP (1) | EP3394079A4 (enExample) |
| JP (2) | JP6995757B2 (enExample) |
| CN (1) | CN108713023B (enExample) |
| AU (2) | AU2016379417B2 (enExample) |
| CA (1) | CA3009525A1 (enExample) |
| WO (1) | WO2017112909A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017112904A1 (en) | 2015-12-23 | 2017-06-29 | Oric Pharmaceuticals, Inc. | Inhibitors of glucocorticoid receptor |
| EP3394078A4 (en) | 2015-12-23 | 2019-11-27 | Oric Pharmaceuticals, Inc. | INHIBITORS OF THE GLUCOCORTICIDE RECEPTOR |
| JP6995757B2 (ja) * | 2015-12-23 | 2022-01-17 | オリック ファーマシューティカルズ，インク． | グルココルチコイド受容体の阻害剤 |
| WO2018068021A1 (en) | 2016-10-07 | 2018-04-12 | Oric Pharmaceuticals, Inc. | Inhibitors of glucocorticoid receptor |
| TW202010502A (zh) * | 2018-04-11 | 2020-03-16 | 美商歐瑞克製藥公司 | 包含糖皮質激素受體拮抗劑之固體形式與調配物及其用途 |
| CN118265717A (zh) * | 2022-03-31 | 2024-06-28 | 成都赛璟生物医药科技有限公司 | 一种cdk8抑制剂及其制备方法和用途 |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2528434B1 (fr) | 1982-06-11 | 1985-07-19 | Roussel Uclaf | Nouveaux 19-nor steroides substitues en 11b et eventuellement en 2, leur procede de preparation et leur application comme medicament |
| ZA8231B (en) | 1981-01-09 | 1982-11-24 | Roussel Uclaf | New 11 -substituted steroid derivatives, their preparation, their use as medicaments, the compositions containing them and the new intermediates thus obtained |
| FR2522328B1 (fr) | 1982-03-01 | 1986-02-14 | Roussel Uclaf | Nouveaux produits derives de la structure 3-ceto 4,9 19-nor steroides, leur procede de preparation et leur application comme medicaments |
| JP2785023B2 (ja) | 1987-12-30 | 1998-08-13 | ルセル―ユクラフ | １７α位置を置換された１７β―ＯＨ―１９―ノルステロイドの新誘導体、その製造方法、その薬剤としての使用及びそれを含有する製薬組成物 |
| JPH02188599A (ja) | 1988-11-16 | 1990-07-24 | Roussel Uclaf | ３―ケト―デルタ―４，９―１９―ノルステロイドから誘導される新物質及びそれらよりなる薬剤 |
| DE3921059A1 (de) | 1989-06-23 | 1991-01-10 | Schering Ag | 11(beta)-aryl-4-estrene, verfahren zu ihrer herstellung sowie deren verwendung als arzneimittel |
| FR2651435A1 (fr) | 1989-09-07 | 1991-03-08 | Roussel Uclaf | Nouvelle utilisation de composes anti-progestomimetiques. |
| DE4018167A1 (de) * | 1990-06-01 | 1991-12-05 | Schering Ag | Verfahren zur herstellung von 10(beta)-h-steroiden |
| DE4042007A1 (de) | 1990-12-22 | 1992-06-25 | Schering Ag | 6,7-modifizierte-11(beta)-aryl-4-estrene |
| DE69413829T2 (de) | 1993-08-04 | 1999-04-15 | Akzo Nobel N.V., Arnheim/Arnhem | Antiglucocorticoidsteroide zur behandlung von angststörungen |
| WO1995017192A1 (en) | 1993-12-22 | 1995-06-29 | The Salk Institute For Biological Studies | Methods for reducing multidrug resistance |
| WO1996023503A1 (de) | 1995-02-02 | 1996-08-08 | Schering Aktiengesellschaft | Progesteronantagonisten für die herstellung von arzneimitteln zur behandlung von dysfunktionellen uterinen blutungen |
| IL118974A (en) * | 1995-08-17 | 2001-09-13 | Akzo Nobel Nv | History 11 - (Transformed Phenyl) - Astra - 4, 9 - Diane, their preparation and pharmaceutical preparations containing them |
| IL122740A (en) | 1997-01-15 | 2003-09-17 | Akzo Nobel Nv | 16-hydroxy-11-(substituted phenyl)-estra-9,4-diene derivatives, their preparation and pharmaceutical compositions containing them |
| CN1085078C (zh) * | 1998-01-07 | 2002-05-22 | 沈志华 | 用于大月份引产的复合药物 |
| US6512130B1 (en) | 2000-09-05 | 2003-01-28 | Council Of Scientific And Industrial Research | Mifepristone analogue, process for the preparation thereof and use thereof |
| EP1285927A3 (de) | 2001-08-16 | 2005-06-29 | Schering Aktiengesellschaft | Verwendung von Glucocorticoid-Rezeptorantagonisten zur Vorbeugung und Behandlung von Erkrankungen des männlichen Reproduktionssystems |
| US7250408B2 (en) | 2002-12-16 | 2007-07-31 | Bayer Schering Pharma Ag | Glucocorticoid receptor antagonists for prophylaxis and therapy of glucocorticoid-mediated hypogonadism, of sexual dysfunction and/or infertility |
| AU2007245022A1 (en) | 2006-03-29 | 2007-11-08 | The Regents Of The University Of California | Diarylthiohydantoin compounds |
| PL1989218T3 (pl) | 2006-02-17 | 2010-06-30 | Janssen Pharmaceutica Nv | Pochodne 17-fosforosteroidów użyteczne jako modulatory receptora progesteronowego |
| US8569274B2 (en) | 2007-04-20 | 2013-10-29 | Preglem S.A. | Progesterone antagonist and selective progesterone modulator in the treatment of excessive uterine bleeding |
| JP5804395B2 (ja) | 2011-02-03 | 2015-11-04 | ポップ テスト オンコロジー エルエルシー | 診断と治療のためのシステムおよび方法 |
| EP2545922A1 (en) | 2011-07-12 | 2013-01-16 | PregLem S.A. | Treatment of excessive menstrual bleeding associated with uterine fibroids |
| US20130029953A1 (en) | 2011-07-28 | 2013-01-31 | Klaus Nickisch | Progesterone antagonists |
| PT3111950T (pt) | 2012-02-24 | 2021-10-19 | Univ Chicago | Métodos e composições relacionadas com antagonismo recetor de glucocorticoide e cancro da próstata |
| EP2641602A1 (en) | 2012-03-23 | 2013-09-25 | PregLem S.A. | Method for treating gynecological diseases |
| US9096641B2 (en) | 2013-06-05 | 2015-08-04 | Evestra, Inc. | Imidazolyl progesterone antagonists |
| EP3079475B1 (en) | 2013-12-11 | 2020-10-07 | Sloan-kettering Institute For Cancer Research | Glucocorticoid inhibitors for treatment of prostate cancer |
| CN104530166B (zh) | 2014-12-04 | 2016-08-24 | 陕西汉江药业集团股份有限公司 | 选择性还原4,6-共轭双烯-3-酮甾体化合物的方法 |
| WO2017112904A1 (en) | 2015-12-23 | 2017-06-29 | Oric Pharmaceuticals, Inc. | Inhibitors of glucocorticoid receptor |
| EP3394078A4 (en) | 2015-12-23 | 2019-11-27 | Oric Pharmaceuticals, Inc. | INHIBITORS OF THE GLUCOCORTICIDE RECEPTOR |
| JP6995757B2 (ja) * | 2015-12-23 | 2022-01-17 | オリック ファーマシューティカルズ，インク． | グルココルチコイド受容体の阻害剤 |
| WO2018068021A1 (en) | 2016-10-07 | 2018-04-12 | Oric Pharmaceuticals, Inc. | Inhibitors of glucocorticoid receptor |
| WO2018227129A1 (en) | 2017-06-09 | 2018-12-13 | Regents Of The University Of Minnesota | Skin care formulations and skin cancer treatment |
| TW202010502A (zh) | 2018-04-11 | 2020-03-16 | 美商歐瑞克製藥公司 | 包含糖皮質激素受體拮抗劑之固體形式與調配物及其用途 |
-
2016
- 2016-12-22 JP JP2018533668A patent/JP6995757B2/ja not_active Expired - Fee Related
- 2016-12-22 AU AU2016379417A patent/AU2016379417B2/en not_active Ceased
- 2016-12-22 CA CA3009525A patent/CA3009525A1/en active Pending
- 2016-12-22 EP EP16880126.4A patent/EP3394079A4/en not_active Withdrawn
- 2016-12-22 US US16/065,627 patent/US11208432B2/en active Active
- 2016-12-22 WO PCT/US2016/068448 patent/WO2017112909A1/en not_active Ceased
- 2016-12-22 CN CN201680082460.0A patent/CN108713023B/zh not_active Expired - Fee Related
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2020
- 2020-10-19 AU AU2020256460A patent/AU2020256460A1/en not_active Abandoned
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2021
- 2021-09-10 JP JP2021147955A patent/JP2022003045A/ja active Pending
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| AU2016379417B2 (en) | 2020-09-24 |
| EP3394079A4 (en) | 2019-08-21 |
| AU2016379417A1 (en) | 2018-07-19 |
| JP6995757B2 (ja) | 2022-01-17 |
| AU2020256460A1 (en) | 2020-11-12 |
| JP2019500376A (ja) | 2019-01-10 |
| JP2022003045A (ja) | 2022-01-11 |
| US20210002324A1 (en) | 2021-01-07 |
| CN108713023B (zh) | 2021-10-26 |
| CN108713023A (zh) | 2018-10-26 |
| EP3394079A1 (en) | 2018-10-31 |
| US11208432B2 (en) | 2021-12-28 |
| WO2017112909A1 (en) | 2017-06-29 |
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